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Effectiveness of motion-inducing devices for sensorimotor learning in hemiplegic rats

Research Project

Project/Area Number 18K10808
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

Kaneko Hidekazu  国立研究開発法人産業技術総合研究所, 情報・人間工学領域, 主任研究員 (20356801)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsリハビリ / 学習 / エラー / アシスト / 運動感覚 / フィードバック / 脳損傷 / 片麻痺
Outline of Final Research Achievements

Robotic rehabilitation has the potential to facilitate the plasticity of injured neural networks by inducing motor sensations. We hypothesized that, in a sensory-motor association task, learning can be facilitated by inducing motor sensation similar to that accompanied by the correct voluntary response. In our previous studies, we have demonstrated that the application of external force inducing such motor sensation applying 200-300 ms after task cues can facilitate learning of a rat choice reaction-time task. In this study, we investigated whether task learning is facilitated by the intervention immediately before response timing. As a result, the intervention producing an incorrect/correct motion immediately before the rat making a response did not affect to the progress of task learning. Because the task is a kind of sensorimotor associative learning, the intervention referring to the task cue suggested to be essential to the effective intervention.

Academic Significance and Societal Importance of the Research Achievements

ロボット技術をリハビリテーションに活用することへの期待が高まっている。本研究では、タスク遂行中に強制的に応答動作を引き起こすことが可能な動物実験モデルを用いて、応答動作のタイミングに合わせて強制的に応答様動作を誘発することで学習過程に介入可能かどうか検証した。その結果、空圧刺激と応答動作の関係を学習するタスクにおいては、空圧刺激に関連付けて応答動作様の運動感覚を誘発することが重要であると考えられた。本研究によって得られた知見は、ロボット技術をリハビリ分野に適用する際の効果の裏付けを与えるものであり、神経科学的知見に基づくニューロリハビリテーション技術の今後の研究において有用と考えている。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Products Report
  • Research Products

    (6 results)

All 2022 2019 2018

All Presentation (4 results) (of which Int'l Joint Research: 2 results) Patent(Industrial Property Rights) (2 results)

  • [Presentation] Motion analysis of a mechanical intervention intended to facilitate learning in rats2019

    • Author(s)
      Hidekazu Kaneko, Ko Ayusawa
    • Organizer
      The 5th EU-Japan Workshop on Neurorobotics/Cognitive Systems
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脳梗塞片麻痺ラットの動作分析によるロボティックリハビリテーション訓練メカニズムの解明2019

    • Author(s)
      金子 秀和,鮎澤光
    • Organizer
      第40回バイオメカニズム学術講演会(SOBIM2019)
    • Related Report
      2019 Research-status Report
  • [Presentation] 運動学的介入に伴う神経可塑性の促進2018

    • Author(s)
      金子秀和
    • Organizer
      産総研 ニューロリハビリテーション シンポジウム2018
    • Related Report
      2018 Research-status Report
  • [Presentation] Effects of motion-inducing devices on task learning in rats -Facilitating remodeling in the central nervous system-2018

    • Author(s)
      Hidekazu Kaneko
    • Organizer
      4th EU-Japan Workshop on Neurorobotics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] 運動訓練装置およびその作動方法2022

    • Inventor(s)
      金子 秀和, 山田 亨
    • Industrial Property Rights Holder
      国立研究開発法人産業技術総合研究所
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2022
    • Related Report
      Products Report
  • [Patent(Industrial Property Rights)] 運動訓練装置およびその作動方法2019

    • Inventor(s)
      金子秀和、山田亨
    • Industrial Property Rights Holder
      産業技術総合研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-009217
    • Filing Date
      2019
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-03-28  

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