The effects of connectin (titin) on muscle and joint function before and after eccentric contractions
| Project/Area Number |
18K10832
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59020:Sports sciences-related
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| Research Institution | Hosei University |
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Principal Investigator |
Ochi Eisuke 法政大学, 生命科学部, 准教授 (90468778)
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| Co-Investigator(Kenkyū-buntansha) |
中里 浩一 日本体育大学, 保健医療学部, 教授 (00307993)
菊池 直樹 日本体育大学, 体育学部, 准教授 (10739478)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 遺伝子多型 / 動物モデル / 筋損傷 / 伸張性収縮 / 柔軟性 / 関節弛緩性 / 関節柔軟性 / タイチン / コネクチン / 筋硬度 / 伸張生収縮 / 骨格筋 |
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| Outline of Final Research Achievements |
We investigated the effect of Connectin/Titin SNPs on the muscle and joint functions before and after eccentric exercise in human and animal model. As the results, the untrained subjects of C/C allele shows reduced joint flexibility after eccentric exercise but no change in muscle stiffness. In addition, we tried to make the rat model with CRISPR-Cas9, but we could not complete in the period.
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| Academic Significance and Societal Importance of the Research Achievements |
関節柔軟性に深く関係する骨格筋の硬さ（筋硬度）と細胞骨格タンパク質関連遺伝子多型、あるいは伸張性収縮後の関節柔軟性・筋硬度の変化と遺伝的要因との関連性を明らかにした論文はなく、動物モデルによって関節柔軟性のメカニズムの解明を行った研究も少ない。そこで、本研究は関節柔軟性に関与するコネクチン（titin）に着目し、関節柔軟性・筋硬度の運動による変化を検討した。その結果、関節柔軟性はTITIN遺伝子多型と関連するものの、筋硬度との関連は健常者・競技者ともに認められなかった。以上の結果は関節柔軟性を規定する骨格筋の硬さ以外の要因がTITIN遺伝子と関連することを示唆していると考えられる。
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Report
(5 results)
Research Products
(44 results)
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[Presentation] Effect of home-based high-intensity interval training and behavioral modification using information and communication technology on cardiorespiratory fitness and exercise habits among sedentary breast cancer survivors: the habit-B randomized controlled trial in progress.2021
Author(s)
Tsuji K, Ochi E, Shimizu Y, Kuchiba A, Narisawa T, Okubo R, Ueno T, Shimazu T, Kinoshita T, Suto A, Sakurai N, Matsuoka Y
Organizer
22nd World Congress of Psycho-Oncology & Psychosocial Academy
Related Report
Int'l Joint Research
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[Presentation] Effect of home-based smartphone- supported high-intensity interval training on cardiorespiratory fitness in breast cancer survivors: A randomized controlled trial of the habit-B program.2021
Author(s)
Ochi E, Tsuji K, Narisawa T, Shimizu Y, Kuchiba A, Suto A, Jimbo K, Takayama S, Ueno T, Sakurai N, Matsuoka Y.
Organizer
44nd Annual San Antonio Breast Cancer Symposium (SABCS)
Related Report
Int'l Joint Research
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