The role of the Egr3 in the mechanism of age-related functional decline of skeletal muscle stem cells
| Project/Area Number |
18K10835
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59020:Sports sciences-related
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
Ogura Yuji 聖マリアンナ医科大学, 医学部, 講師 (90509952)
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| Co-Investigator(Kenkyū-buntansha) |
黒坂 光寿 聖マリアンナ医科大学, 医学部, 助教 (40553970)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | サルコペニア / 筋性幹細胞 / 筋衛星細胞 / Egr3 / 筋再生 / 筋サテライト細胞 / 老化 / 骨格筋 |
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| Outline of Final Research Achievements |
The results of this study showed that Egr3 is associated with Pax7 of muscle satellite cells in old age. However, there was no relationship between Egr3 and muscle satellite cell function in the study using individual young mice. Therefore, to elucidate the relationship between Egr3 and sarcopenia, it may be necessary to eliminate Egr3 in old age or after identifying the critical period when the relationship between Egr3 and sarcopenia becomes important.
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| Academic Significance and Societal Importance of the Research Achievements |
高齢期における筋力などの筋機能の低下は、サルコペニアと呼ばれており、サルコペニアの抑制や軽減は、健康長寿に寄与すると考えられる。Egr3が筋衛星細胞の働きに関与する可能性を示唆した本研究の報告は、Egr3の機能を制御することでサルコペニアの対抗策を開発できる可能性を示唆しており、上記問題の克服の一助になることが期待される。
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Report
(4 results)
Research Products
(8 results)
