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Effects of exercise and 5-aminolevulinic acid on the lifestyle-related diseases prevention

Research Project

Project/Area Number 18K10885
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionShinshu University

Principal Investigator

MORIKAWA MAYUKO  信州大学, 先鋭領域融合研究群バイオメディカル研究所, 助教(特定雇用) (10596068)

Co-Investigator(Kenkyū-buntansha) 能勢 博  信州大学, 医学部, 特任教授 (40128715)
増木 静江  信州大学, 学術研究院医学系, 教授 (70422699)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords中高年者 / インターバル速歩 / 5-アミノレブリン酸 / 生活習慣病予防 / 体力向上 / 炎症関連遺伝子 / 5-アミノレブリン酸 / 生活習慣病改善 / エピジェネティック効果 / 乳酸 / インターバル速歩トレーニング / 生活習慣病症状改善
Outline of Final Research Achievements

We continued the interval walking training, but for middle-aged and elderly people who have high symptoms of lifestyle-related diseases, we have them carry out the interval walking training for one month, and during that time, the condition to take 5-aminolevulinic acid (It was divided into two groups, ALA condition) and placebo condition. The purpose was to examine the effects on physical fitness, lifestyle-related disease-related indicators, and methylation of inflammation-related genes.
From this result, it was found that ALA supplementation improved IWT achievement, but the effect on physical fitness and lifestyle-related disease-related indicators will be further analyzed in the future.

Academic Significance and Societal Importance of the Research Achievements

我々は、加齢に伴う体力(筋力)の低下が生活習慣病の根本原因であることを示唆する結果を得た。さらに健常中高年者を対象に、1週間のインターバル速歩+5-アミノレブリン酸摂取がミトコンドリア機能を改善することを明らかにした。そこで、生活習慣病「患者」を対象に、より長期間(1ヶ月間)の「インターバル速歩」+5-アミノレブリン酸摂取の体力、生活習慣病に及ぼす効果を個体・遺伝子レベルで検証する。これらが明らかになれば、高齢者の生活習慣病予防、介護予防の為の運動処方の導入の一助となると考える。さらにはその結果、高齢者医療費を削減でき、我が国存亡の危機の解決策になるのではないかと考える。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (12 results)

All 2021 2020 2019

All Journal Article (10 results) (of which Peer Reviewed: 5 results) Presentation (2 results) (of which Invited: 2 results)

  • [Journal Article] High-intensity interval walking training using internet of things (IoT): past and future2021

    • Author(s)
      Nose H, Morikawa M, Furihata M, and Masuki S
    • Journal Title

      J Phys Fitness Sports Med

      Volume: 10 Pages: 1-6

    • NAID

      130008037445

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Internet of Things (IoT) system and field sensors for exercise intensity measurements2020

    • Author(s)
      Masuki S, Morikawa M, and Nose H
    • Journal Title

      Comprehensive Physiology

      Volume: 10 Pages: 1207-1240

    • DOI

      10.1002/cphy.c190010

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 運動+乳製品摂取の体力向上・生活習慣病予防効果2020

    • Author(s)
      増木静江、森川真悠子、内田晃司、能勢 博
    • Journal Title

      Milk Science

      Volume: 69 Pages: 166-172

    • NAID

      130007886356

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 熱中症予防のためのソフトドリンクに求められること2020

    • Author(s)
      能勢 博、内田晃司、片岡由布子、森川 真悠子、増木静江
    • Journal Title

      ソフトドリンク技術資料

      Volume: 191 Pages: 1-97

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 運動+乳製品摂取の体力向上・生活習慣病改善効果2020

    • Author(s)
      増木静江、森川真悠子、内田晃司、能勢 博
    • Journal Title

      糖尿病・内分泌代謝科

      Volume: 50 Pages: 448-455

    • NAID

      40022291937

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
  • [Journal Article] Internet of Things (IoT) System and Field Sensors for Exercise Intensity Measurements2020

    • Author(s)
      Masuki S, Morikawa M, Nose H
    • Journal Title

      Comprehensive Physiology

      Volume: in press

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] High intensity walking time is a key determinant to increase physical fitness and improve health outcomes after interval walking training in middle-aged and older people2019

    • Author(s)
      Masuki S, Morikawa M, Nose H
    • Journal Title

      Mayo Clinic Proceedings

      Volume: 94 Pages: 2415-2426

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 10歳若返る!「インターバル速歩」-生活習慣病・介護予防のための新しい運動処方システム―2019

    • Author(s)
      能勢 博、森川真悠子、増木静江
    • Journal Title

      月間せんい

      Volume: 72 Pages: 101-107

    • NAID

      40021820622

    • Related Report
      2019 Research-status Report
  • [Journal Article] 運動と乳製品摂取で熱中症を予防する、In:一歩先ゆく熱中症・脱水予防2019

    • Author(s)
      能勢 博、内田晃司、森川真悠子、増木静江
    • Journal Title

      救急医学

      Volume: 43 Pages: 942-948

    • Related Report
      2019 Research-status Report
  • [Journal Article] 糖尿病患者向けの効果的な歩行のコツーインターバル速歩のススメ―2019

    • Author(s)
      能勢 博、森川真悠子、降幡真由佳、増木静江
    • Journal Title

      Modern Physician

      Volume: 39 Pages: 49-52

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] 運動+乳製品摂取の体力向上・生活習慣病予防効果、次代を拓く酪農科学のフロンティア研究2020

    • Author(s)
      増木静江、森川真悠子、内田晃司、能勢 博
    • Organizer
      酪農科学シンポジウム2020、諏訪、9.4.(招待講演)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 「インターバル速歩」の新展開-運動を核にした健康長寿社会の構築-2020

    • Author(s)
      増木静江、森川真悠子、能勢 博
    • Organizer
      第41回日本基礎老化学会シンポジウム、Web開催、11.13-11.14(招待講演)
    • Related Report
      2020 Annual Research Report
    • Invited

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Published: 2018-04-23   Modified: 2022-01-27  

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