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Metabolic modification by probiotic lactic acid bacteria via modification of circadian rhythm

Research Project

Project/Area Number 18K11039
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionObihiro University of Agriculture and Veterinary Medicine (2020-2021)
National Agriculture and Food Research Organization (2018-2019)

Principal Investigator

WATANABE JUN  帯広畜産大学, 畜産学部, 教授 (10374729)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsプロバイオティクス / 乳酸菌 / 体内時計 / 代謝調節 / 胆汁酸
Outline of Final Research Achievements

This research project aimed to clarify anti-obesity activities of probiotic lactic acid bacteria (LAB) via the modification of circadian rhythm. LAB from Japanese pickles were screened based on survivability in GI tract atmosphere and bile salt hydrolase (BSH) activity. Isolate with high BSH activity showed anti-adiposity effect in high-fat diet administered mice, although that with low BSH activity failed to show the effect. Deoxycholic acid, a deconjugated bile acid, increased oscillation of clock gene expressions and affected lipid metabolism in circadian synchronized HepG2 cells.

Academic Significance and Societal Importance of the Research Achievements

これまでに肥満抑制作用を示すプロバイオティクス乳酸菌が報告されている。本研究では、乳酸菌により生じる脱抱合型胆汁酸がエネルギー代謝の概日リズム調節を通じて抗肥満作用を示すという作業仮説を検証した。データは十分ではないものの、この仮説を支持する知見が得られた。本研究の成果をさらに検証することで、概日リズムが関与する肥満のみならず種々の疾病改善効果を有する食品設計につながることが期待される。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2020 2019

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Lactobacillus plantarum Shinshu N-07 isolated from fermented Brassica rapa L. attenuates visceral fat accumulation induced by high-fat diet in mice2020

    • Author(s)
      Yin T.、Bayanjargal S.、Fang B.、Inaba C.、Mutoh M.、Kawahara T.、Tanaka S.、Watanabe J.
    • Journal Title

      Beneficial Microbes

      Volume: 11 Issue: 7 Pages: 1-14

    • DOI

      10.3920/bm2020.0009

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] Anti-obesity effect of Lactobacillus plantarum Shinshu N-07 isolated from fermented Brassica rapa L.2019

    • Author(s)
      Jun Watanabe, Tingyu Yin, Bayanjargal Sandagdorj, Bowen Fang, Takeshi Kawahara, and Sachi Tanaka
    • Organizer
      IPC2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 野沢菜漬け由来Lactobacillus plantarum Shinshu N-07株の食事誘導肥満抑制作用2019

    • Author(s)
      渡辺純、Tingyu Yin、Bayanjargal Sandagdorj、Bowen Fang、河原岳志、田中沙智
    • Organizer
      日本食品科学工学会第66回大会
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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