Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Outline of Final Research Achievements |
Stroke-prone spontaneously hypertensive rats (SHRSP) have lower weight than normotensive rats (WKY). The results obtained from investigating for skeletal muscle showed that slow muscle, but not fast muscle had specific lower weight in SHRSP. Comprehensive gene expression analysis for soleus, slow muscle, clarified protein involved in protein degradation highly expressed in slow muscle of SHRSP. Further analysis for upstream of the protein showed that the upstream protein which expresses mainly in fast muscle tended to highly express in slow muscle of SHRSP. This indicated that ectopic expression in slow muscle of the upstream protein might be involved in slow muscle specific hypotrophy in SHRSP.
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