Effect of exercise trainning on skin-gas nitric oxide

• Project/Area Number: 18K11126
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Nagoya Institute of Technology
• Principal Investigator: ITOH HIROSHI 名古屋工業大学, 工学(系)研究科(研究院), 教授 (10203168)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 一酸化窒素 / 運動 / 皮膚ガス / 血管年齢指標 / 脈波伝搬速度 / 血流量 / 内皮細胞 / 毛細血管 / トレーニング

Outline of Final Research Achievements

The present study aimed to confirm relationship between skin-gas NO concentration and PWV(pulse wave velocity) during 60%HRmax cycle exercise.
Significant negative relationships were found between skin-gas NO concentration and PWV in this study. These results suggests that an increase in shear stress on vessels might be much more effective for an increase in skin-gas NO concentration during the whole body exercise. Furthermore, sympathetic nervous activity, circulating hormones, exercised muscle-derived metabolites including reactive oxygen species might also affect the production of NO during the exercise. Thus increased NO production during exercise decreased PWV.

Academic Significance and Societal Importance of the Research Achievements

皮膚から放出されるガス（皮膚ガス）の中にNOが含まれることを発見し、高感度、高精度な皮膚ガス中NO濃度分析システムを構築することに成功している（平成18-20年度科学研究費補助金　基盤研究C）。皮膚ガス中NO濃度測定は、非侵襲かつ非観血的で、非常に微量なガスから瞬時に実施できるという特徴がある。また、これまでに行ってきた測定では、ヒトの皮膚ガス中NO濃度の再現性は高く、生体情報モニターとして安定した成績を得られることを確認している。このように、皮膚ガスの研究は他では行われていないため学術的独自性がある。

Research Products

• [Presentation] Shear stress on cutaneous capillary endothelial during whole body exercise increase skin-gas nitric oxide concentration. (2020)
  • Author(s): Toya, Y. , Eguchi, Y. , Goshima, K. , Tajiri, N. , Tsuda, T. , Itoh, H.
  • Organizer: European College of Sport Science
  • Int'l Joint Research
• [Presentation] ハンドグリップを用いた局所における最大下反復運動時の皮膚ガス中アセトン濃度変化と血流量変化 (2019)
  • Author(s): 代谷広一郎、江口勇樹、戸谷友亮、伊藤宏
  • Organizer: 日本運動生理学会
• [Presentation] Shear stress on cutaneous capillary endothelial during whole body exercise increase skin-gas nitric oxide concentration (2019)
  • Author(s): Toya, Y., Eguchi, Y., Goshima, K., Tajiri, N, Tsuda, T., Itoh, H.
  • Organizer: European College of Sport Science
  • Int'l Joint Research
• [Presentation] Relationship between skin-gas nitric oxide concentration and capillary velocity following repeated submaximal handgrip exercise (2019)
  • Author(s): Eguchi, Y., Toya, Y., Goshima, K., Tajiri, N., Tsuda, T., Itoh, H.
  • Organizer: European College of Sport Science
  • Int'l Joint Research
• [Presentation] Relationship between skin-gas acetone concentration collected from surface of exercised muscles and hand as a non-exercised region following repeated knee-extension exercise (2019)
  • Author(s): Itoh, H.,Tajiri, N., Kato, H., Utsu, U., Minagawa, A., Kato, A., Tsuda, T
  • Organizer: European College of Sport Science
  • Int'l Joint Research
• [Presentation] Repeated knee-extension exercise increase skin-gas acetone concentration on surface of exercised leg muscles compared to opposite non-exercised leg muscles (2019)
  • Author(s): Ayame Kato, Hirotaka Kato, Yuki Utsu, Ayumu Minagawa, Naotaka Tajiri, Takao Tsuda, Hiroshi Itoh
  • Organizer: European College of Sport Science
  • Int'l Joint Research
• [Presentation] Shear stress on cutaneous capillary endothelial during whole body exercise increase skin-gas nitric oxide concentration. (2019)
  • Author(s): Yusuke Toya et al.
  • Organizer: European College of Sport Science
  • Int'l Joint Research
• [Presentation] Relationship between skin-gas nitric oxide concentration and capillary velocity following repeated submaximal handgrip exercise. (2019)
  • Author(s): Yuki Eguchi et al.
  • Organizer: European College of Sport Science
  • Int'l Joint Research