Visualization of cellular response to cyclic pressure stress
| Project/Area Number |
18K12033
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 静水圧 / 周期的圧力 / メカノバイオロジー / 機械刺激 / 圧力 / 咬合圧 |
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| Outline of Final Research Achievements |
Activities of daily living such as walking and sitting pressurize articular cartilage. However, the effect of pressurization on chondrocytes is poorly understood due to the lack of methods that directly observe cells under high pressure conditions. Here we developed high hydrostatic system to observe human cell dynamics under high pressure condition. We also found high hydrostatic pressure regulates signaling pathway in chondrocyte. Our results suggest the model of the homeostasis of articular cartilage under high pressure conditions.
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| Academic Significance and Societal Importance of the Research Achievements |
高齢化社会における生活の質(QOL)の維持や向上は必須であるが、歩行や咀嚼等の生命活動に伴ったずり応力、圧力、伸展圧縮等の様々な機械刺激が生体組織に必ず生じるため、機械刺激を考慮した細胞や器官の受容応答メカニズムの解明の遂行なくして、QOLの向上に向けた根本的な改善に繋がらない。本研究では、細胞の圧力受容応答メカニズムに迫る研究であった。また、本研究成果は、軟骨組織のリモデリング機構の解明に繋がる知見であり、今後の治療応用にの発展に寄与するものと考える。
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Report
(5 results)
Research Products
(16 results)
