Elucidation of the pathophysiology of right ventricular dysfunction by comparison between the echocardiographic parameters and the digital analysis of pathology
| Project/Area Number |
18K12098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 90130:Medical systems-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Daimon Masao 東京大学, 医学部附属病院, 講師 (80343094)
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| Co-Investigator(Kenkyū-buntansha) |
中尾 倫子 東京大学, 医学部附属病院, 助教 (30597216)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 画像診断 / 心不全 / 心エコー / 心機能 / 右心室 / 心エコー図 / 病理 |
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| Outline of Final Research Achievements |
We evaluated the prognostic values of the right ventricular (RV) function parameters using echocardiography in patients with dilated cardiomyopathy (DCM) and compared them with digitally processed pathological findings. In a study of 109 patients with DCM, cardiac events were observed in 41 cases within one year, and the combination of right ventricular longitudinal strain (RVSL) and fractional area change (FAC) was most useful for predicting the cardiac events (hazard ratio 11.3). However, echocardiographic parameters considering the RV-PA coupling did not improve the prognostic values. In 31 patients who underwent myocardial biopsy, RV myocardial fibrosis was quantified using a digital process and compared with the echocardiographic parameters. However, the RV myocardial fibrosis rate did not correlate with RV systolic parameters such as RVLS, FAC, and TAPSE.
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| Academic Significance and Societal Importance of the Research Achievements |
心エコーによる右心機能指標はDCMの予後予測に有用であるが、単一の指標でなくRVSLとFACの組み合わせることで、より的確な予後予測を行うことが可能となることが明らかとなった。少なくともDCM症例では、RV-PA coupling指標は予後予測能を改善しない。一方で、右心機能指標は、単に心筋線維化だけでなく圧や容量などの血行動態や液性因子など他の因子に影響を受けている可能性がある。今後右心機能改善の治療法を開発する上で、これらの病態を解明する研究の進展が望まれる。
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Influence of visceral adiposity accumulation on adverse left and right ventricular mechanics in the community.2019
Author(s)
Sawada N, Nakanishi K, Daimon M, Yoshida Y, Ishiwata J, Hirokawa M, Nakao T, Morita H, Di Tullio MR, Homma S, Komuro I.
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Journal Title
Eur J Prev Cardiol.
Volume: -
Issue: 18
Pages: 2006-2015
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Prognostic value of the combined evaluation of right ventricular function by conventional and 2D speckle-tracking echocardiography in patients with non-ischemic dilated cardiomyopathy2020
Author(s)
Jumpei Ishiwata, Masao Daimon, Koki Nakanishi, Tadafumi Sugimoto, Takayuki Kawata, Tomoko Nakao, Megumi Hirokawa, Naoko Sawada, Yuriko Yoshida, Eisuke Amiya, Masaru Hatano, Hiroyuki Morita, Issei Komuro
Organizer
第84回日本循環器病学会学術集会
Related Report
Int'l Joint Research
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[Presentation] Alteration of Cardiac Performance and Serum B-type Natriuretic Peptide Level in Healthy Aging; Speckle-tracking Echocardiographic Study2019
Author(s)
Yoshida Y, Nakanichi K, Daimon M, Ishiwata J, Sawada N, Hirokawa M, Kaneko H, Nakao T, Mizuno Y, Morita H, Di Tullio M, Homma S, Komuro
Organizer
American Heart Association Scientific sessions 2019
Related Report
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[Presentation] Serum Uric Acid Level and Subclinical Left Ventricular Dysfunction: A Community-based Cohort Study2019
Author(s)
Yoshida Y, Nakanichi K, Daimon M, Ishiwata J, Sawada N, Hirokawa M, Kaneko H, Nakao T, Mizuno Y, Morita H, Di Tullio M, Homma S, Komuro I
Organizer
American Heart Association Scientific sessions 2019
Related Report
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