Development of Ultrasonic C-mode imaging system using power Doppler method and clinical application for evatuation of disease activity in rheumatoid arthritis

• Project/Area Number: 18K12103
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90130:Medical systems-related
• Research Institution: Kyoto University
• Principal Investigator: Fujii Yasutomo 京都大学, 医学研究科, 教授 (00337338)
• Co-Investigator(Kenkyū-buntansha): 田川 憲男 東京都立大学, システムデザイン研究科, 教授 (00244418) ; 橋本 求 大阪公立大学, 大学院医学研究科, 教授 (60512845)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 関節リウマチ / 関節エコー / パワードプラ / C-mode / 寛解 / 超音波 / C-mode像 / パワードプラ法

Outline of Final Research Achievements

The purpose of this study is to develop a cheap C-mode image making system equipped with a probe which can detect positional information, evaluating disease activity of the rheumatoid arthritis (RA) that is insufficient by the conventional rating system more appropriately. Because a scanning range is small as for the hands and feet knuckle joint which is an area of predilection for RA, only tilting of a probe made it possible to scan enough area in the affected lesion.Adding improvement on the trial manufacture system,which we had made before,could provide fair positional information of a probe by the simple scanning. Big progress is seen, and the analysis of the clinical data mainly on the joint echo that ran side by side leads to publication, the presentation at the meeting of several articles.

Academic Significance and Societal Importance of the Research Achievements

我々が前もって作成した比較的安価な試作システムに改良工夫を加えることにより、探触子の単純な走査で位置情報に関して評価に耐えうると思われる結果が得られたことは、C-mode法という、「古くて新しい」画像診断法の他領域への応用および再評価につながる可能性がある。また、並行して行った関節エコー所見を中心とした臨床データの解析結果（出版論文）はリウマチのシステマティックな早期診断のみならず、新しい治療法の層別化に寄与するものであり、ここ数年ドラスティックに変化しているリウマチ臨床に貢献するものと確信している。

Research Products

• [Journal Article] Machine learning-based prediction of relapse in rheumatoid arthritis patients using data on ultrasound examination and blood test (2022)
  • Author(s): Matsuo Hidemasa、Kamada Mayumi、Imamura Akari、Shimizu Madoka、Inagaki Maiko、Tsuji Yuko、Hashimoto Motomu、Tanaka Masao、Ito Hiromu、Fujii Yasutomo
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 7224-7224
  • DOI: 10.1038/s41598-022-11361-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Positive rate and prognostic significance of the superb microvascular imaging signal in joints of rheumatoid arthritis patients in remission with normal C-reactive protein levels and erythrocyte sedimentation rates (2021)
  • Author(s): Matsuo Hidemasa、Tabuchi Yuya、Yukimatsu Risako、Imamura Akari、Shimizu Madoka、Inagaki Maiko、Tsuji Yuko、Nakabo Shuichiro、Tsuji Hideaki、Nakajima Toshiki、Hashimoto Motomu、Ito Hiromu、Morinobu Akio、Fujii Yasutomo
  • Journal Title: Journal of Medical Ultrasonics Volume: 48 Issue: 3 Pages: 353-359
  • DOI: 10.1007/s10396-021-01102-5
  • Peer Reviewed
• [Journal Article] Region specificity of rheumatoid foot symptoms associated with ultrasound-detected synovitis and joint destruction (2021)
  • Author(s): Ishie Shinichiro、Ito Hiromu、Nakabo Shuichiro、Tsuji Hideaki、Nakajima Toshiki、Tsuji Yuko、Inagaki Maiko、Furu Moritoshi、Hashimoto Motomu、Murata Koichi、Murakami Kosaku、Nishitani Kohei、Tanaka Masao、Fujii Yasutomo、Matsuda Shuichi
  • Journal Title: Modern Rheumatology Volume: 32 Issue: 1 Pages: 127-135
  • DOI: 10.1080/14397595.2021.1912905
  • Peer Reviewed
• [Journal Article] Severe joint deformity and patient global assessment of disease are associated with discrepancies between sonographic and clinical remission: A cross-sectional study of rheumatoid arthritis patients (2020)
  • Author(s): Nakabo Shuichiro、Tsuji Yuko、Inagaki Maiko、Tsuji Hideaki、Nakajima Toshiki、Murakami Kosaku、Terao Chikashi、Hashimoto Motomu、Furu Moritoshi、Tanaka Masao、Ito Hiromu、Fujii Takao、Mimori Tsuneyo、Fujii Yasutomo
  • Journal Title: Modern Rheumatology Volume: 31 Issue: 2 Pages: 334-342
  • DOI: 10.1080/14397595.2020.1751922
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prediction of recurrence and remission by superb microvascular imaging method in rheumatoid arthritis (2019)
  • Author(s): Matsuo H. Imamura A., Shimizu M., Inagaki M. Tsuji Y., Nakabo S., Hashimoto M., Ito H., Tanaka S., Mimori T., Fujii Y.
  • Journal Title: J Med Ultrasonics Volume: 46 Issue: 1 Pages: 131-138
  • DOI: 10.1007/s10396-019-00978-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Feasibility to reduce the number of the joints tested by musculoskeletal ultrasonography, by focusing on the joints with patients’ complaint: cross-sectional observational study of rheumatoid arthritis. (2019)
  • Author(s): Kawahara R, Nakabo S, Shimizu M, Yamamoto H, Sasai T, Nakamura Y, Funakoshi S, Gon Y, Taniguchi M, Nakajiama T, Hiwa R, Hashimoto M, Tomizawa T, Azukizawa M, Nishitani K, Murata K, Tanaka M, Ito H, Mimori T, Fujii Y.
  • Journal Title: Mod Rheumatol. Volume: 28 Issue: 6 Pages: 1-7
  • DOI: 10.1080/14397595.2019.1680095
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Evaluation of Risk Factors for Arteriosclerosis using Carotid Ultrasonography in Japanese Patients with Rheumatoid Arthritis. (2019)
  • Author(s): Yamamoto, H., Nakajima, T., Kawara, R., Nakabo, S., Hashimoto, M., Yamamoto, W,, Masuda, I., Ito, H., Mimori, T., Fujii, Y.
  • Journal Title: Int J Rheum Dis. Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 関節リウマチ診療に貢献する超音波検査 (2022)
  • Author(s): 松尾英将、藤井康友
  • Organizer: 臨床検査医学会
  • Invited
• [Presentation] 2種のDopplerモードとそれらのgain変化の比較による臨床的緩解RA患者の手指関節の評価法最適化の検討 (2020)
  • Author(s): 今村朱里、田淵裕也、橋本求、松尾英将、藤井康友
  • Organizer: 第67回日本臨床検査医学会学術集会
• [Presentation] 関節リウマチ患者の深寛解評価における関節超音波検査の有用性 (2020)
  • Author(s): 松尾英将、行松理沙子、田淵裕也、今村朱里、橋本求、伊藤宣、藤井康友
  • Organizer: 第67回日本臨床検査医学会学術集会
• [Presentation] 関節超音波検査・血液検査データを組み合わせた機械学習による関節リウマチの再燃予測 (2020)
  • Author(s): 松尾英将、青木沙央梨、橋本求、伊藤宣、松田秀一、鎌田真由美、藤井康友
  • Organizer: 日本超音波医学会第93回学術集会
• [Presentation] 関節リウマチ患者の再燃予測に有用な関節エコー検査部位の探索 (2019)
  • Author(s): 今村朱里、松尾英将、田淵裕也、清水円、稲垣舞子、辻侑子、橋本求、伊藤宣、藤井康友
  • Organizer: 日本超音波医学会第92回学術集会
• [Presentation] 関節リウマチ患者の予後予測に有用な関節エコー検査部位およびカットオフ値の検討 (2019)
  • Author(s): 松尾英将、今村朱里、清水円、稲垣舞子、辻侑子、中坊周一郎、橋本求、伊藤宣、田中司朗、三森経世、藤井康友
  • Organizer: 第66回日本臨床検査医学会学術集会
• [Presentation] 関節リウマチ患者における肘関節エコー評価の重要性 (2018)
  • Author(s): 157. 清水円、中島俊樹、河原理恵、山本博子、橋本求、中坊周一郎、富澤琢也、山本渉、伊藤宣、藤井康友.
  • Organizer: 日本超音波医学会第91回学術集会奨励賞ノミネート
• [Presentation] 関節リウマチ患者の訴えに基づく観察により関節エコー検査を簡素化する試み. (2018)
  • Author(s): 158. 河原理恵、中坊周一郎、清水円、中島俊樹、山本博子、橋本求、富澤琢也、山本渉、伊藤宣、藤井康友.
  • Organizer: 日本超音波医学会第91回学術集会、奨励賞受賞
• [Presentation] A Certain Fraction Of Active Established Rheumatoid Arthritis Patients With Significant Joint Destruction Is Misclassified As Boolean Remission: A Cross-section Study Using Ultrasonography. (2018)
  • Author(s): 159. Fuji Y, Nakabo S, Tsuji Y, Inagaki M, Tsuji H, Nakajima T, Hashimoto M, Mimori T.
  • Organizer: 30th EUROSON Congress of the EFSUMB
  • Int'l Joint Research