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Demonstration of quantitative attenuation correction method in real-time monitoring of therapeutic particle beams

Research Project

Project/Area Number 18K12124
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 90130:Medical systems-related
Research InstitutionNational Institutes for Quantum Science and Technology

Principal Investigator

Yamaguchi Mitsutaka  国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 主幹研究員 (10375404)

Co-Investigator(Kenkyū-buntansha) 神谷 富裕  群馬大学, 大学院理工学府, 教授 (70370385)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords粒子線がん治療 / イメージング / 電子制動放射線 / X線カメラ / ビームイメージング / 二次電子制動放射 / 減弱補正 / 制動輻射 / 粒子線治療 / ビームモニタリング手法
Outline of Final Research Achievements

Acrylic targets were irradiated with therapeutic particle beams and the secondary bremsstrahlung emitted from the therapeutic particle tracks in the target was measured with a pixel scintillation X-ray camera to capture the particle tracks and measure the energy spectrum. In the irradiation experiments, the lateral thickness (water equivalent thickness) of the acrylic target was varied from 2.5 to 6.5 cm and energy spectra were obtained. As a result, it was confirmed that the number of counts decreased significantly in the low-energy band as the lateral thickness increased, while the change in the number of counts was small in the high-energy band, indicating that the water equivalent thickness could be estimated.

Academic Significance and Societal Importance of the Research Achievements

粒子線照射時に、減衰補正に必要となる情報や、入射粒子のエネルギー情報を、非侵襲的に取得する手法は他に存在せず、創造性の高い研究である。また、電子制動輻射の情報を粒子線到達位置モニタリングに利用しようというアイデアは研究代表者が世界で初めて提案したものであり独創性の高い研究といえる。さらに、制動輻射スペクトルの実験データをエネルギー分解能の高い検出器を用いて取得し発生理論との比較を行うことで、制動輻射発生メカニズムの研究の進展に寄与できる。このほか、研究により得られる制動輻射による二次放射線被曝の基礎データは、放射線医学・生物学において粒子線の体内影響に関する新たな研究の萌芽にも繋がる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (18 results)

All 2021 2020 2019 2018

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results) Presentation (11 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Estimation of shifts of therapeutic carbon-ion beams owing to cavities in a polyethylene target by measuring prompt X-ray images2020

    • Author(s)
      Yamaguchi Mitsutaka、Yamamoto Seiichi、Kitano Maki、Kubota Yoshiki、Sakai Makoto、Akagi Takashi、Nagao Yuto、Kawachi Naoki
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 59 Issue: 8 Pages: 087001-087001

    • DOI

      10.35848/1347-4065/aba22a

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dose image prediction for range and width verifications from carbon ion‐induced secondary electron bremsstrahlung x‐rays using deep learning workflow2020

    • Author(s)
      Yamaguchi Mitsutaka、Liu Chih‐Chieh、Huang Hsuan‐Ming、Yabe Takuya、Akagi Takashi、Kawachi Naoki、Yamamoto Seiichi
    • Journal Title

      Medical Physics

      Volume: 47 Issue: 8 Pages: 3520-3532

    • DOI

      10.1002/mp.14205

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sensitivity improvement of YAP(Ce) cameras for imaging of secondary electron bremsstrahlung x-rays emitted during carbon-ion irradiation: problem and solution2020

    • Author(s)
      Yamamoto Seiichi、Yamaguchi Mitsutaka、Akagi Takashi、Kitano Maki、Kawachi Naoki
    • Journal Title

      Physics in Medicine & Biology

      Volume: 65 Issue: 10 Pages: 105008-105008

    • DOI

      10.1088/1361-6560/ab7a6e

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel estimation method of water-equivalent thicknesses of secondary particle tracks using secondary electron bremsstrahlung emitted from therapeutic ion beams for attenuation correction2020

    • Author(s)
      Yamaguchi Mitsutaka、Sakai Makoto、Nagao Yuto、Kikuchi Mikiko、Arakawa Kazuo、Kawachi Naoki
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

      Volume: 954 Pages: 161607-161607

    • DOI

      10.1016/j.nima.2018.11.066

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Simulation Study on Estimation of Bragg-Peak Shifts via Machine Learning Using Proton-Beam Images Obtained by Measurement of Secondary Electron Bremsstrahlung2020

    • Author(s)
      Yamaguchi Mitsutaka、Nagao Yuto、Kawachi Naoki
    • Journal Title

      IEEE Transactions on Radiation and Plasma Medical Sciences

      Volume: 4 Issue: 2 Pages: 253-261

    • DOI

      10.1109/trpms.2019.2928016

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a YAP(Ce) camera for the imaging of secondary electron bremsstrahlung x-ray emitted during carbon-ion irradiation toward the use of clinical conditions2019

    • Author(s)
      Yamamoto Seiichi、Yamaguchi Mitsutaka、Akagi Takashi、Sasano Makoto、Kawachi Naoki
    • Journal Title

      Physics in Medicine & Biology

      Volume: 64 Issue: 13 Pages: 135019-135019

    • DOI

      10.1088/1361-6560/ab2072

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] A simulation study on reduction of the background component using veto counters for imaging of therapeutic proton beams by measuring secondary electron bremsstrahlung using a parallel-hole collimator2019

    • Author(s)
      Yamaguchi Mitsutaka、Nagao Yuto、Kawachi Naoki
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 58 Issue: 2 Pages: 021005-021005

    • DOI

      10.7567/1347-4065/aafb00

    • NAID

      210000135322

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 治療用粒子線可視化を目的とした二次電子制動輻射スペクトルの解析による水等価厚算出手法の実証2021

    • Author(s)
      佐鳥凌太、山口充孝、山本誠一、酒井真理、長尾悠人、河地有木、加田渉、神谷富裕
    • Organizer
      第82回応用物理学会秋季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Monte Carlo simulation on prompt X-ray imaging of therapeutic carbon-ion beams in a human-head phantom2021

    • Author(s)
      山口充孝、山本誠一、喜多野真紀、赤城卓、長尾悠人、河地有木
    • Organizer
      2021 Nuclear Science Symposium and Medical Imaging Conference
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of an integrated imaging system for simultaneous imaging of prompt X-rays and luminescence at the same position2021

    • Author(s)
      喜多野真紀、山本誠一、赤城卓、山口充孝、酒井真理、河地有木
    • Organizer
      第121回日本医学物理学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Deep learning-based dose image predictions from prompt x-ray images for proton therapy2021

    • Author(s)
      矢部卓也、山口充孝、リュウ チ・チー、歳藤利行、河地有木、山本誠一
    • Organizer
      第121回日本医学物理学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 頭部ファントム中の治療用炭素イオン線の即発X線による可視化2021

    • Author(s)
      山口充孝、山本誠一、喜多野真紀、赤城卓、長尾悠人、河地有木
    • Organizer
      第68回応用物理学会春季学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] 標的内空洞による治療用炭素イオン線のずれの即発X線測定による推定2020

    • Author(s)
      山口充孝、山本誠一、喜多野真紀、久保田佳樹、酒井真理、赤城卓、長尾悠人、河地有木
    • Organizer
      第81回応用物理学会秋季学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] Imaging and range estimation of proton induced secondary electron bremsstrahlung X-rays using high sensitivity YAP(Ce) camera2020

    • Author(s)
      喜多野真紀、山本誠一、歳藤利行、山口充孝、河地有木
    • Organizer
      第119回日本医学物理学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Prediction of dose images from secondary electron bremsstrahlung X-rays using advanced deep learning workflow2020

    • Author(s)
      山口充孝、リュウ チ・チー、フアン シュアン・ミン、矢部卓也、赤城卓、河地有木、山本誠一
    • Organizer
      第119回日本医学物理学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] A Simulation Study on Estimation of Bragg-Peak Shifts via Machine Learning Using Proton-Beam Images Obtained by Measurement of Secondary Electron Bremsstrahlung2019

    • Author(s)
      Yamaguchi Mitsutaka、Nagao Yuto、Kawachi Naoki
    • Organizer
      2019 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] A simulation study on background reduction using veto counters for imaging of therapeutic proton beams by measuring secondary electron bremsstrahlung2018

    • Author(s)
      Mitsutaka Yamaguchi, Yuto Nagao, Naoki Kawachi
    • Organizer
      2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] A novel estimation method of water-equivalent thicknesses of secondary particle tracks using secondary electron bremsstrahlung emitted from therapeutic ion beams for attenuation correction2018

    • Author(s)
      Mitsutaka Yamaguchi, Makoto Sakai, Yuto Nagao, Mikiko Kikuchi, Kazuo Arakawa, Naoki Kawachi
    • Organizer
      2018 Symposium on Radiation Measurements and Applications (SORMA XVII)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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