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Resting-State Brain Connectivity and Intervention for ASD: Consideration for a Better Outcome

Research Project

Project/Area Number 18K13352
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 10030:Clinical psychology-related
Research InstitutionChiba University

Principal Investigator

Tsuchiyagaito Aki  千葉大学, 子どものこころの発達教育研究センター, 特任研究員 (30778452)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
KeywordsMRI / 安静時脳機能 / 脳機能結合 / 反芻 / 考え込み / うつ / ASD / DMN / ニューロフィードバック / EEG / fMRI / 脳機能イメージング / 脳波
Outline of Final Research Achievements

Among the symptoms of Autism Spectrum Disorder (ASD), we focused on cognitive inflexibility and repetitive thinking. We aimed to delineate the brain circuit related to repetitive negative thinking (RNT). Due to the COVID-19, instead of recruiting ASD, we utilized existing dataset with depression and healthy subjects, and analyzed resting-state fMRI data. We found that functional connectivity (FC) between precuneus and right temporo-parietal junction (rTPJ), both of which are located in the default mode network, was highly correlated with general RNT including depressive rumination. In a similar vein, we also found that FC between anterior insular (AI) and superior temporal sulcus (STS) was highly correlated with brooding RNT regardless of the severity of depression and anxiety. STS is a brain region often found to show abnormal activity among ASD populations. Our results indicate that brain's functional alterations in STS could be a feature of trans-diagnostic aspects of RNT.

Academic Significance and Societal Importance of the Research Achievements

うつ病の脳機能結合不全としては、従来、default mode network (DMN) の関与が報告されてきた。本研究においても、うつ状態および反芻(ルミネーション)といった悲観的な反復思考に関連する脳機能結合として、DMN内の機能不全を認めた。一方、うつや不安の程度を統制したところ、思考の非柔軟性や考え込み(ブルーディング)と関連する脳回路として、島前部と上側頭溝の関与を認めた。上側頭溝は言語やTheory of Mindを担う脳領域であり、ASDにおける機能不全が数多く報告されている部位である。思考の非柔軟性と関連する部位として、上側頭溝の果たす診断横断的機能が示唆された。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (29 results)

All 2022 2021 2020 2019 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (24 results) (of which Int'l Joint Research: 24 results)

  • [Int'l Joint Research] Laureate Institute for Brain Research(米国)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Prevent breaking bad: A proof of concept study of rebalancing the brain's rumination circuit with real‐time fMRI functional connectivity neurofeedback2020

    • Author(s)
      Tsuchiyagaito Aki、Misaki Masaya、Zoubi Obada Al、Paulus Martin、Bodurka Jerzy、Tulsa 1000 Investigators
    • Journal Title

      Human Brain Mapping

      Volume: 42 Issue: 4 Pages: 922-940

    • DOI

      10.1002/hbm.25268

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Connectome-wide search for functional connectivity locus associated with pathological rumination as a target for real-time fMRI neurofeedback intervention2020

    • Author(s)
      Misaki Masaya、Tsuchiyagaito Aki、Al Zoubi Obada、Paulus Martin、Bodurka Jerzy
    • Journal Title

      NeuroImage: Clinical

      Volume: 26 Pages: 102244-102244

    • DOI

      10.1016/j.nicl.2020.102244

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Self‐regulation of ventromedial prefrontal cortex activation using real‐time fMRI neurofeedback?Influence of default mode network2019

    • Author(s)
      Mayeli Ahmad、Misaki Masaya、Zotev Vadim、Tsuchiyagaito Aki、Al Zoubi Obada、Phillips Raquel、Smith Jared、Stewart Jennifer L.、Refai Hazem、Paulus Martin P.、Bodurka Jerzy
    • Journal Title

      Human Brain Mapping

      Volume: 41 Issue: 2 Pages: 342-352

    • DOI

      10.1002/hbm.24805

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] EEG Microstates Temporal Dynamics Differentiate Individuals with Mood and Anxiety Disorders From Healthy Subjects2019

    • Author(s)
      Al Zoubi O, Mayeli A, Tsuchiyagaito A, Misaki M, Zotev V, Refai H, Paulus M, Bodurka J, the Tulsa 1000 Investigators
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 13 Pages: 56-56

    • DOI

      10.3389/fnhum.2019.00056

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Resting-State Functional Connectivity of Repetitive Negative Thinking in Major Depression2022

    • Author(s)
      Aki Tsuchiyagaito, Stella M. Sanchez, Masaya Misaki, Rayus Kuplicki, Heekyeong Park, Martin P. Paulus, and Salvador M. Guinjoan
    • Organizer
      Society of Biological Psychiatry
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Connectivity-Based fMRI Neurofeedback Targeting the Repetitive Negative Thinking in Depression2022

    • Author(s)
      Aki Tsuchiyagaito, Salvador M. Guinjoan, Namik Kirlic, Stella M. Sanchez, Kate D. Fitzgerald, Martin P. Paulus, and Masaya Misaki
    • Organizer
      Organization for Human Brain Mapping
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Repetitive Negative Thinking, interoceptive processing, and hippocampus2022

    • Author(s)
      Heekyeong Park, Rayus Kuplicki, Aki Tsuchiyagaito, Stella Sanchez, T1000 Investigators, Martin Paulus, Salvador Guinjoan
    • Organizer
      Cognitive Neuroscience Society
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Repetitive Negative Thinking influences hippocampal activity and visceral interoceptive processing2022

    • Author(s)
      Heekyeong Park, Rayus Kuplicki, Aki Tsuchiyagaito, Stella Sanchez, T1000 Investigators, Martin Paulus, Salvador Guinjoan
    • Organizer
      Society of Biological Psychiatry
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Real-time fMRI neurofeedback augmented mindfulness training in maltreated youth: a randomized sham-controlled trial2022

    • Author(s)
      Namik Kirlic, Zsofia P. Cohen, Aki Tsuchiyagaito, Gabriella Cochran, Xiaoqian Yu, Manpreet K. Singh, Robin L. Aupperle, Masaya Misaki, Martin P. Paulus
    • Organizer
      Society of Biological Psychiatry
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitative MRI evaluation of reduced myelin content in white matter tracts in major depressive disorder2022

    • Author(s)
      Masaya Misaki, Aki Tsuchiyagaito, Beni Mulyana, Rayus Kuplicki, Martin Paulus
    • Organizer
      International Society for Magnetic Resonance in Medicine
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Individual Variability in Brain Self-regulation by Neurofeedback Associated with Treatment Effects2022

    • Author(s)
      Masaya Misaki, Aki Tsuchiyagaito, Salvador Guinjoan
    • Organizer
      Organization for Human Brain Mapping
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of left-amygdala fMRI neurofeedback positive emotion training on immune mediators in major depressive disorder2021

    • Author(s)
      Aki Tsuchiyagaito, Jared L. Smith, Nour El-Sabbagh, Vadim Zotev, Masaya Misaki, Obada Al Zoubi, T. Kent Teague, Martin P. Paulus, Jerzy Bodurka, Jonathan Savitz
    • Organizer
      Society of Biological Psychiatry
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation of Frontal Alpha Asymmetry EEG Neurofeedback in Major Depression Using Simultaneous fMRI2021

    • Author(s)
      Vadim Zotev, Aki Tsuchiyagaito, Jerzy Bodurka
    • Organizer
      International Society for Magnetic Resonance in Medicine
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Closed-Loop tACS-fMRI: Online Optimization of tACS Stimulation to Enhance Fronto-parietal Connectivity2021

    • Author(s)
      Beni Mulyana, Aki Tsuchiyagaito, Jared Smith, Masaya Misaki, Samuel Cheng, Martin Paulus, Hamed Ekhtiari, and Jerzy Bodurka
    • Organizer
      International Society for Magnetic Resonance in Medicine
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ventromedial prefrontal cortex fMRI neurofeedback training focused on positively-valenced future thinking for individuals experiencing suicidal thoughts2021

    • Author(s)
      Robin Aupperle, Aki Tsuchiyagaito, Tim McDermott, Elisabeth Akeman, Jessica Santiago, Namik Kirlic, Danielle DeVille, Jared Smith, Martin Paulus, Jerzy Bodurka
    • Organizer
      American College of Neuropsychopharmacology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neurofeedback augmented mindfulness training for adolescents with early life stress exposure: a feasibility study2021

    • Author(s)
      Namik Kirlic, Zsofia Cohen, Aki Tsuchiyagaito, Masaya Misaki, Robin Aupperle, Jerzy Bodurka, Martin Paulus
    • Organizer
      American College of Neuropsychopharmacology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] A Connectivity-Based Real-Time fMRI Neurofeedback Targeting the Rumination.2020

    • Author(s)
      Tsuchiyagaito A, Misaki M, Smith J, Paulus M, Bodurka J.
    • Organizer
      Organization for Human Brain Mapping
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] FMRI Neurofeedback Amygdala Training Influences Immune Responses.2020

    • Author(s)
      Tsuchiyagaito A, Smith J, El-Sabbagh N, Mayeli A, Zotev V, Misaki M, Paulus M, Bodurka J, Savitz J.
    • Organizer
      Organization for Human Brain Mapping
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neuroimaging and neuromodulation protocols related to positive future thinking to enhance understanding of hope and suicide2019

    • Author(s)
      Robin Aupperle, Aki Tsuchiyagaito, Tim McDermott, Elisabeth Akeman, Jessica Santiago, Namik Kirlic, Danielle DeVille, Jared Smith, Martin Paulus, Jerzy Bodurka
    • Organizer
      Society of Biological Psychiatry
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Ventromedial prefrontal cortex fMRI neurofeedback training during positively-valenced future thinking with participants experiencing suicidal thoughts; a feasibility study.2019

    • Author(s)
      Robin Aupperle, Aki Tsuchiyagaito, Tim McDermott, Elisabeth Akeman, Jessica Santiago, Namik Kirlic, Danielle DeVille, Jared Smith, Martin Paulus, Jerzy Bodurka
    • Organizer
      Anxiety and Depression Association of America
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Feasibility of a novel real-time fMRI neurofeedback protocol for enhancing prefrontal cortex engagement during emotional cognitive control2019

    • Author(s)
      Timothy J. McDermott, Aki Tsuchiyagaito, Ahmad Mayeli, Jerzy Bodurka, Martin P. Paulus, Robin L. Aupperle
    • Organizer
      Society of Biological Psychiatry
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Modulation of amygdala activity with fMRI neurofeedback during simultaneous EEG recordings: Implication for novel depression and PTSD interventions2019

    • Author(s)
      Tsuchiyagaito A, Bodurka J.
    • Organizer
      World Congress of Biological Psychiatry
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] How Many Sessions Needed for fMRI Neurofeedback Training to Increase Amygdala Activity and to Influence Functional Connectivity?2019

    • Author(s)
      Tsuchiyagaito A, Mayeli A, Al Zoubi O, Misaki M, Zotev V, Bodurka J.
    • Organizer
      Society of Biological Psychiatry’s 2019 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Targeted vmPFC Modulation with fMRI Neurofeedback Changes Functional Connectivity in Depression.2019

    • Author(s)
      Tsuchiyagaito A, Misaki M, Mayeli A, Zotev V, Al Zoubi O, Paulus M, Aupperle R, Bodurka J.
    • Organizer
      Society of Biological Psychiatry’s 2019 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Simultaneous EEG-fMRI-Eye Tracker Measurements for Determining Subject’s Vigilance during Resting-State fMRI.2019

    • Author(s)
      Mayeli A, Al Zoubi O, Misaki M, Tsuchiyagaito A, Refai H, Paulus M, Bodurka J.
    • Organizer
      Society of Biological Psychiatry’s 2019 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Brain regional connectome-wide search identified a resting-state functional connectivity locus within precuneus associated with rumination symptom severity in mood and anxiety disorders.2019

    • Author(s)
      Misaki M, Tsuchiyagaito A, Al Zoubi O, Paulus M, Bodurka J.
    • Organizer
      International Society for Magnetic Resonance in Medicine 27th Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] BOLD Representation of Canonical EEG Microstates.2019

    • Author(s)
      Al Zoubi O, Mayeli A, Misaki M, Zotev V, Tsuchiyagaito A, Tulsa 1000 Investigators, Refai H, Paulus M, Bodurka J.
    • Organizer
      International Society for Magnetic Resonance in Medicine 27th Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Simultaneous EEG-fMRI-Eye Tracker Study for Measuring Subject’s Vigilance during Resting-State fMRI2019

    • Author(s)
      Mayeli A, Al Zoubi O, Misaki M, Tsuchiyagaito A, Refai H, Paulus M, Bodurka J.
    • Organizer
      Organization for Human Brain Mapping’s 2019 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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