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Continuum mechanics in fertilization dynamics: A mathematical approach based on experimental data

Research Project

Project/Area Number 18K13456
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 12040:Applied mathematics and statistics-related
Research InstitutionKyoto University (2019-2023)
The University of Tokyo (2018)

Principal Investigator

Kenta Ishimoto  京都大学, 数理解析研究所, 准教授 (00741141)

Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords流体力学 / 連続体力学 / 数理モデル
Outline of Final Research Achievements

In this research project, we have aimed at establishing modelling methodology for fluid-structure coupling problem of microswimmers such as spermatozoa. Notable achievements include elastohydrodynamic instability of bacterial swimming via a flexible hook. Also, in this project, a novel automatic detection of flagellar shape has been invented, and this method enables one to analyse a large amount of flagellar samples. We also successfully derived swimming formula for the fluid-structure coupling problem, which is helpful in designing a proper shape space.

Academic Significance and Societal Importance of the Research Achievements

精子を含む微生物の遊泳ダイナミクスは、感染症や不妊治療といった医学的観点だけでなく、細胞スケールのマイクロロボットの開発の基礎ともなる。このような複合的な学際領域における、数理的な基盤やモデリング手法の基礎づけは、広範囲の学術的分野を支える知見となる。特に成果のあったバクテリアの壁面近傍の挙動に関しては、バイオフィルムの形成メカニズムを理解する上でも重要だと考えている。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (51 results)

All 2023 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (9 results) Journal Article (25 results) (of which Int'l Joint Research: 19 results,  Peer Reviewed: 24 results,  Open Access: 22 results) Presentation (16 results) (of which Int'l Joint Research: 8 results,  Invited: 9 results) Remarks (1 results)

  • [Int'l Joint Research] University of Oxford/University of Birmingham(英国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] University of Oxford/University College London/University of Bath(英国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] UCAS(中国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] University of Oxford/University College London(英国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] オックスフォード大学(英国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] ノースカロライナA&T大学(米国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] オックスフォード大学/ケンブリッジ大学(英国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] INRIA/ストラスブール大学(フランス)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] University of Oxford/University of Cambridge(英国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] A Multiscale Numerical Simulation of Quasi-Two-Dimensional Bacterial Turbulence Using a Regularized Stokeslet Representation2023

    • Author(s)
      Ishimoto Kenta
    • Journal Title

      Springer Proceedings in Mathematics & Statistics

      Volume: 429 Pages: 215-226

    • DOI

      10.1007/978-3-031-35871-5_11

    • ISBN
      9783031358708, 9783031358715
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Squirmer hydrodynamics near a periodic surface topography2023

    • Author(s)
      Ishimoto Kenta、Gaffney Eamonn A.、Smith David J.
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 11 Pages: 1123446-1123446

    • DOI

      10.3389/fcell.2023.1123446

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Jeffery’s Orbits and Microswimmers in Flows: A Theoretical Review2023

    • Author(s)
      Ishimoto Kenta
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 92 Issue: 6 Pages: 062001-062001

    • DOI

      10.7566/jpsj.92.062001

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Onsager’s Variational Principle for Nonreciprocal Systems with Odd Elasticity2023

    • Author(s)
      Lin Li-Shing、Yasuda Kento、Ishimoto Kenta、Hosaka Yuto、Komura Shigeyuki
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 92 Issue: 3 Pages: 033001-033001

    • DOI

      10.7566/jpsj.92.033001

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hydrodynamic slender-body theory for local rotation at zero Reynolds number2023

    • Author(s)
      Walker Benjamin J.、Ishimoto Kenta、Gaffney Eamonn A.
    • Journal Title

      Physical Review Fluids

      Volume: 8 Issue: 3 Pages: 034101-034101

    • DOI

      10.1103/physrevfluids.8.034101

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Systematic parameterizations of minimal models of microswimming2023

    • Author(s)
      Walker Benjamin J.、Ishimoto Kenta、Gaffney Eamonn A.
    • Journal Title

      Physical Review Fluids

      Volume: 8 Issue: 3 Pages: 034102-034102

    • DOI

      10.1103/physrevfluids.8.034102

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The control of particles in the Stokes limit2022

    • Author(s)
      Walker B.J.、Ishimoto K.、Gaffney E.A.、Moreau C.
    • Journal Title

      Journal of Fluid Mechanics

      Volume: 942

    • DOI

      10.1017/jfm.2022.253

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Self-organized swimming with odd elasticity2022

    • Author(s)
      Ishimoto Kenta、Moreau Clement、Yasuda Kento
    • Journal Title

      Physical Review E

      Volume: 105 Issue: 6 Pages: 064603-064603

    • DOI

      10.1103/physreve.105.064603

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emergent rheotaxis of shape-changing swimmers in Poiseuille flow2022

    • Author(s)
      Walker B.J.、Ishimoto K.、Moreau C.、Gaffney E.A.、Dalwadi M.P.
    • Journal Title

      Journal of Fluid Mechanics

      Volume: 944

    • DOI

      10.1017/jfm.2022.474

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Time-correlation functions for odd Langevin systems2022

    • Author(s)
      Yasuda Kento、Ishimoto Kenta、Kobayashi Akira、Lin Li-Shing、Sou Isamu、Hosaka Yuto、Komura Shigeyuki
    • Journal Title

      The Journal of Chemical Physics

      Volume: 157 Issue: 9 Pages: 095101-095101

    • DOI

      10.1063/5.0095969

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Most probable path of an active Brownian particle2022

    • Author(s)
      Yasuda Kento、Ishimoto Kenta
    • Journal Title

      Physical Review E

      Volume: 106 Issue: 6 Pages: 064120-064120

    • DOI

      10.1103/physreve.106.064120

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modelling Motility: The Mathematics of Spermatozoa2021

    • Author(s)
      Gaffney Eamonn A.、Ishimoto Kenta、Walker Benjamin J.
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 9 Pages: 710825-710825

    • DOI

      10.3389/fcell.2021.710825

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Computer-assisted beat-pattern analysis and the flagellar waveforms of bovine spermatozoa2020

    • Author(s)
      Walker Benjamin J.、Phuyal Shiva、Ishimoto Kenta、Tung Chih-Kuan、Gaffney Eamonn A.
    • Journal Title

      Royal Society Open Science

      Volume: 7 Issue: 6 Pages: 200769-200769

    • DOI

      10.1098/rsos.200769

    • NAID

      120006879512

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficient simulation of filament elastohydrodynamics in three dimensions2020

    • Author(s)
      Walker Benjamin J.、Ishimoto Kenta、Gaffney Eamonn A.
    • Journal Title

      Physical Review Fluids

      Volume: 5 Issue: 12 Pages: 123103-123103

    • DOI

      10.1103/physrevfluids.5.123103

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regularized representation of bacterial hydrodynamics2020

    • Author(s)
      Ishimoto Kenta、Gaffney Eamonn A.、Walker Benjamin J.
    • Journal Title

      Physical Review Fluids

      Volume: 5 Issue: 9 Pages: 093101-093101

    • DOI

      10.1103/physrevfluids.5.093101

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Helicoidal particles and swimmers in a flow at low Reynolds number2020

    • Author(s)
      Ishimoto Kenta
    • Journal Title

      Journal of Fluid Mechanics

      Volume: 892

    • DOI

      10.1017/jfm.2020.142

    • NAID

      120007142252

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 微生物の流体力学2020

    • Author(s)
      石本健太
    • Journal Title

      数理科学

      Volume: 682 Pages: 67-74

    • NAID

      120006936354

    • Related Report
      2019 Research-status Report
  • [Journal Article] The N-flagella problem: Elastohydrodynamic motility transition of multi-flagellated bacteria2019

    • Author(s)
      Ishimoto Kenta、Lauga Eric
    • Journal Title

      Proceedings of the Royal Society A

      Volume: 印刷中 Issue: 2225 Pages: 20180690-20180690

    • DOI

      10.1098/rspa.2018.0690

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pairwise hydrodynamic interactions of synchronized spermatozoa2019

    • Author(s)
      Walker Benjamin J.、Ishimoto Kenta、Gaffney Eamonn A.
    • Journal Title

      Physical Review Fluids

      Volume: 4 Issue: 9 Pages: 093101-093101

    • DOI

      10.1103/physrevfluids.4.093101

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Bacterial spinning top2019

    • Author(s)
      Ishimoto Kenta
    • Journal Title

      Journal of Fluid Mechanics

      Volume: 880 Pages: 620-652

    • DOI

      10.1017/jfm.2019.714

    • NAID

      120006731561

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Filament mechanics in a half-space via regularised Stokeslet segments2019

    • Author(s)
      Walker B. J.、Ishimoto K.、Gad?lha H.、Gaffney E. A.
    • Journal Title

      Journal of Fluid Mechanics

      Volume: 879 Pages: 808-833

    • DOI

      10.1017/jfm.2019.723

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Boundary behaviours of Leishmania mexicana: A hydrodynamic simulation study2019

    • Author(s)
      Walker Benjamin J.、Wheeler Richard J.、Ishimoto Kenta、Gaffney Eamonn A.
    • Journal Title

      Journal of Theoretical Biology

      Volume: 462 Pages: 311-320

    • DOI

      10.1016/j.jtbi.2018.11.016

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Automated identification of flagella from videomicroscopy via the medial axis transform2019

    • Author(s)
      Walker Benjamin J.、Ishimoto Kenta、Wheeler Richard J.
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 5015-5015

    • DOI

      10.1038/s41598-019-41459-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hydrodynamic Clustering of Human Sperm in Viscoelastic Fluids2018

    • Author(s)
      Ishimoto Kenta、Gaffney Eamonn A.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 15600-15600

    • DOI

      10.1038/s41598-018-33584-8

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Response of monoflagellate pullers to a shearing flow: A simulation study of microswimmer guidance2018

    • Author(s)
      Walker Benjamin J.、Ishimoto Kenta、Wheeler Richard J.、Gaffney Eamonn A.
    • Journal Title

      Physical Review E

      Volume: 98 Issue: 6 Pages: 063111-063111

    • DOI

      10.1103/physreve.98.063111

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Self-organised microswimming of active soft matter2022

    • Author(s)
      K. Ishimoto
    • Organizer
      9th World Congress of Biomechanics
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Emergence of motility pattern in elastohydrodynamic cell swimming2021

    • Author(s)
      石本健太
    • Organizer
      RIMS International Conference: Modeling and Mathematical Analysis of Dynamics of Pattern
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 流体方程式から見る微生物の対称性2021

    • Author(s)
      石本健太
    • Organizer
      日本物理学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 流れ場中の螺旋微生物の運動2020

    • Author(s)
      石本健太
    • Organizer
      日本流体力学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Microswimming stability via fluid-structure interactions2020

    • Author(s)
      K. Ishimoto
    • Organizer
      Fluid-structure interactions: From engineering to biomimetic systems
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] バクテリア独楽の流体力学的安定性2020

    • Author(s)
      石本健太
    • Organizer
      RIMS研究集会「生物数学の理論と応用」
    • Related Report
      2019 Research-status Report
  • [Presentation] A data-driven multi-scale modelling for collective dynamics of human sperm2019

    • Author(s)
      K. Ishimoto, B. J. Walker and E. A. Gaffney
    • Organizer
      Emerging behaviour in active matter: computational challenges
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] N鞭毛問題:バクテリア遊泳の安定性2019

    • Author(s)
      石本健太、E. Lauga
    • Organizer
      日本流体力学会年会2019
    • Related Report
      2019 Research-status Report
  • [Presentation] Elastohydrodynamic stability problems in bacterial swimming2019

    • Author(s)
      K. Ishimoto
    • Organizer
      RIMS Workshop "Mathematical Methods in Biofluid Mechanics
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞運動と流れのダイナミクス2019

    • Author(s)
      石本健太
    • Organizer
      メカノバイオロジー研究を学ぶ2019
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Hydrodynamics of bacterial spinning top2019

    • Author(s)
      K. Ishimoto
    • Organizer
      Annual Meeting of American Physical Society Division of Fluid Dynamics
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ストークス流れにおける流体運動的対称性2019

    • Author(s)
      石本健太
    • Organizer
      現象と数理モデル2019
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 受精ダイナミクスの流体数理2019

    • Author(s)
      石本健太
    • Organizer
      反応拡散系と実験の融合2
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Mathematical methods of fluid mechanics at the scale of the cell2019

    • Author(s)
      K. Ishimoto
    • Organizer
      Interdisciplinary Workshop "Mathematics and Pharmaceutical Sciences"
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Hydrodynamic modelling of human sperm clustering2018

    • Author(s)
      K. Ishimoto
    • Organizer
      11th European Conference on Mathematical and Theoretical Biology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Collective dynamics of human sperm swimming in a viscoelastic medium2018

    • Author(s)
      K. Ishimoto
    • Organizer
      71st Annual Meeting of American Physical Society Division of Fluid Dynamics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Remarks] 研究者の個人webページ

    • URL

      https://www.kurims.kyoto-u.ac.jp/~ishimoto/jp/

    • Related Report
      2021 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2025-01-30  

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