Development of Asymmetric Halogen-Bonding-Donor Catalysts
| Project/Area Number |
18K14226
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 33020:Synthetic organic chemistry-related
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| Research Institution | Chiba Institute of Technology (2019)
Chuo University (2018) |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | ハロゲン結合 / ヨウ素 / 不斉合成 / 有機分子触媒 / 不斉触媒 |
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| Outline of Final Research Achievements |
In this work, we synthesized an asymmetric halogen-bonding-donors bearing a chiral ferrocenyl group. The synthetic method is based on [3+2] cycloaddition of a triazene with a planar chiral ferrocenyl alkyne followed by the deprotonative iodination of the triazolium salt. We found that this halogen-bonding-donor work as a catalyst to efficiently promote the cyanosilylation of aldehydes.
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| Academic Significance and Societal Importance of the Research Achievements |
ヨウ素は日本が産出国世界第２位であり, 日本にとって貴重な資源であるにも関わらず, 日本発の高付加価値ヨウ素含有材料の開発は十分になされていないのが現状である. 本研究では, 環境調和性に優れた次世代型ルイス酸触媒として期待される有機ヨウ素触媒について, 不斉触媒への展開を目指し, 新規キラルヨードトリアゾリウム塩の合成法を開発した. また, 合成した有機ヨウ素触媒がアルデヒドのシリルシアノ化や二酸化炭素とエポキシドとの環化付加反応を効率的に促進することを見いだした.
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Report
(3 results)
Research Products
(9 results)
