Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Outline of Final Research Achievements |
IgE antibody is an essential molecule for the induction of allergic diseases. We found that CRTH2, a receptor for PGD2, promotes IgE production by enhancement of dendritic cells activity and follicular T cell differentiation. Pharmacological inhibition of CRTH2 inhibits the increase of IgE level. CRTH2 inhibitor could be a target for the development of new therapeutic strategy for allergic diseases.
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