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Investigation of social immune systems in eusocial insects

Research Project

Project/Area Number 18K14798
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 45040:Ecology and environment-related
Research InstitutionKwansei Gakuin University

Principal Investigator

SHIMOJI Hiroyuki  関西学院大学, 生命環境学部, 助教 (50726388)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords分業 / 共生細菌 / 免疫 / 社会性昆虫 / アリ / 労働分業 / 社会性免疫 / 防衛機能 / 社会性免疫機構 / 個体間相互作用 / 共生バクテリア / 共生 / 細菌叢
Outline of Final Research Achievements

Using a queenless ant Diacamma cf. indicum from Japan, we revealed that worker-specific symbiont bacterium (Firmicute symbiont) increases the survival rate of workers infected by a pathogen. Interestingly, the protective effect was higher in the foragers than in the nurses. However, some immune-related gene expressions of nurses were upregulated compared with those of the foragers. Therefore, these results suggest that a specific symbiont would be a key to protecting the foragers with physiologically low-immune levels against pathogenetic bacteria.

Academic Significance and Societal Importance of the Research Achievements

アリやミツバチなどの真社会性昆虫は個体間相互作用を基盤として高度な分業体制を築き、様々な環境に適応している。多くのアリは地中に巣を作り高密度環境下で生活しているため、巣の外から持ち込まれる病原性微生物に対する防衛機構が進化していると考えられている。本研究では、老齢になり免疫能力の下がった外役ワーカーが共生細菌を保持することによって、病原性微生物感染に対して生存力が向上することを明らかにした。これらの結果は、社会性昆虫の免疫機構に新しい視点をもたらすものと考えられる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (23 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 3 results) Presentation (14 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (1 results)

  • [Int'l Joint Research] Michael T Siva-Jothy/The University of Sheffield(英国)

    • Related Report
      2019 Research-status Report
  • [Journal Article] The build-up of dominance hierarchies in eusocial insects2022

    • Author(s)
      Shimoji Hiroyuki、Dobata Shigeto
    • Journal Title

      Philosophical Transactions of the Royal Society B: Biological Sciences

      Volume: 377 Issue: 1845 Pages: 20200437-20200437

    • DOI

      10.1098/rstb.2020.0437

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Worker-dependent gut symbiosis in an ant2021

    • Author(s)
      Shimoji Hiroyuki、Itoh Hideomi、Matsuura Yu、Yamashita Rio、Hori Tomoyuki、Hojo Masaru K.、Kikuchi Yoshitomo
    • Journal Title

      ISME Communications

      Volume: 1 Issue: 1

    • DOI

      10.1038/s43705-021-00061-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Social Evolution With Decoupling of Multiple Roles of Biogenic Amines Into Different Phenotypes in Hymenoptera2021

    • Author(s)
      Sasaki Ken、Okada Yasukazu、Shimoji Hiroyuki、Aonuma Hitoshi、Miura Toru、Tsuji Kazuki
    • Journal Title

      Frontiers in Ecology and Evolution

      Volume: 9 Pages: 1-1

    • DOI

      10.3389/fevo.2021.659160

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expressions of conventional vitellogenin and vitellogenin‐like A in worker brains are associated with a nursing task in a ponerine ant2020

    • Author(s)
      Miyazaki S.、Shimoji H.、Suzuki R.、Chinushi I.、Takayanagi H.、Yaguchi H.、Miura T.、Maekawa K.
    • Journal Title

      Insect Molecular Biology

      Volume: 30 Issue: 1 Pages: 113-121

    • DOI

      10.1111/imb.12682

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Worker propensity affects flexible task reversion in an ant.2020

    • Author(s)
      H. Shimoji, N. Kasutani, S. Ogawa, M.K. Hojo
    • Journal Title

      Behavioral Ecology and Sociobiology

      Volume: 74 Issue: 7 Pages: 92-92

    • DOI

      10.1007/s00265-020-02876-3

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Caste‐biased locomotor activities in isolated termites.2020

    • Author(s)
      Shimoji H, Mizumoto N, Oguchi K, Dobata S
    • Journal Title

      Physiological Entomology

      Volume: 45 Issue: 1 Pages: 50-59

    • DOI

      10.1111/phen.12315

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Context‐dependent aggression toward non‐nestmates in the ant Diacamma sp. from Japan.2019

    • Author(s)
      Uematsu J, Hayashi M, Shimoji H, Salazar MOL, Tsuji K
    • Journal Title

      Journal of Ethology

      Volume: 37 Issue: 3 Pages: 259-264

    • DOI

      10.1007/s10164-019-00611-8

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] アリのワーカーの繁殖能力がタスク選択におよぼす影響2022

    • Author(s)
      田中 康就, 土畑 重人, 辻和希, 下地 博之
    • Organizer
      日本生態学会第67回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 動物と微生物の複雑な共生関係を紐解く2022

    • Author(s)
      下地 博之, 稲垣辰哉
    • Organizer
      日本生態学会第67回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] アリ社会の分業維持と自己組織化の関係2021

    • Author(s)
      下地 博之
    • Organizer
      第 40 回日本動物行動学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 共生微生物が切り開く行動生態学の新展開2021

    • Author(s)
      下地 博之
    • Organizer
      第 40 回日本動物行動学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] A pseudo-vertical transmission of bacterial symbiont in an ant2021

    • Author(s)
      Rio YAMASHITA, Yu MATSUURA, Hideomi ITO, Masaru K HOJO, Yoshitomo KIKUCHI, Hiroyuki SHIMOJI
    • Organizer
      日本生態学会第68回
    • Related Report
      2020 Research-status Report
  • [Presentation] アリにおける個体間の分業と免疫活性の関係2021

    • Author(s)
      石塚優介, 松浦優, JANG Seonghan, 田中康就, 北條賢, 菊池義智, 下地博之
    • Organizer
      日本生態学会第68回
    • Related Report
      2020 Research-status Report
  • [Presentation] アリにおける腸内共生細菌の新規伝播様式2021

    • Author(s)
      山下 倫桜, 松浦 優, 伊藤 英臣, 北條 賢, 菊池 義智, 下地 博之
    • Organizer
      第65回日本応用動物昆虫学会
    • Related Report
      2020 Research-status Report
  • [Presentation] アリの柔軟な分業の再構築における日齢とタスク経験の関係2021

    • Author(s)
      田中 康就, 北條 賢, 下地 博之
    • Organizer
      第65回日本応用動物昆虫学会
    • Related Report
      2020 Research-status Report
  • [Presentation] ワーカーの日齢が行動の可塑性へ与える影響2020

    • Author(s)
      下地博之, 糟谷奈那, 北條賢
    • Organizer
      日本生態学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 日本産トゲオオハリにおける共生細菌の伝播様式の解明2020

    • Author(s)
      山下倫桜, 松浦優, 伊藤英臣, 北條賢, 菊池義智, 下地博之
    • Organizer
      日本生態学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 日本産トゲオオハリアリにおけるワーカー間分業とVg-like 遺伝子の関係2020

    • Author(s)
      下地 博之, 小川 真也, 矢口甫, 宮崎智史, 前川清人, 北條賢
    • Organizer
      応用動物昆虫学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Hidden diversity under ground: ant- and nest-associated bacterial communities revealed by meta-genomic analyses2018

    • Author(s)
      下地 博之(関西学院大学)、伊藤 英臣(産総研)、松浦 優(琉球大学)、菊池 義智(産総研)
    • Organizer
      International Union for the Study of Social Insects 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] メタゲノムで解き明かすトゲオオハリアリの細菌叢 -社会に潜むその多様性と分布-2018

    • Author(s)
      下地 博之(関西学院大学)、伊藤 英臣(産総研)、松浦 優(琉球大学)、菊池 義智(産総研)
    • Organizer
      日本微生物生態学会第32回大会
    • Related Report
      2018 Research-status Report
  • [Presentation] メタゲノム解析によって明らかにされたアリのバクテリア叢の多様性2018

    • Author(s)
      下地 博之(関西学院大学)、伊藤 英臣(産総研)、松浦 優(琉球大学)、菊池 義智(産総研)
    • Organizer
      第66回日本生態学会大会
    • Related Report
      2018 Research-status Report
  • [Remarks] 働きアリと共生する新しい腸内細菌の発見

    • URL

      https://www.kwansei.ac.jp/news/detail/4493

    • Related Report
      2021 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

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