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The analysis of neural pathways in arousal maintenance and behavioral alteration under orexin

Research Project

Project/Area Number 18K14846
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 46030:Function of nervous system-related
Research InstitutionUniversity of Tsukuba

Principal Investigator

Hasegawa Emi  筑波大学, 医学医療系, 助教 (40765955)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords睡眠 / ドーパミン / 扁桃体 / オレキシン / カタプレキシー / ファイバーフォトメトリー法 / in vivoレコーディングシステム / 睡眠・覚醒 / 報酬系 / ナルコレプシー / 光遺伝学的手法 / マルチユニット記録 / 覚醒・睡眠
Outline of Final Research Achievements

Since cataplexy has been shown to be induced by positive emotions, I focused on the dopamine nervous system which is highly associated with positive emotions. I observed a very unique pattern in dopamine release during cataplexy. I found that this dopamine pattern is an important factor in cataplexy. Furthermore, I found that NREM-to-REM transitions increase in dopamine in the amygdala during non-REM sleep. Positive emotions in individuals with cataplexy might lead to increases dopamine in the amygdala, mimicking the dynamics that trigger NREM-to-REM transitions.

Academic Significance and Societal Importance of the Research Achievements

扁桃体におけるドーパミン分泌量を制御することにより、レム睡眠量を自在に変化させることが可能になったことから、これを用いて、レム睡眠の役割を解明するとともに、睡眠・覚醒サイクルの生理学的意義の理解を進め、レム睡眠に関わる睡眠障害の発症メカニズムの解明や治療法の開発に役立つことが期待される。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (11 results)

All 2022 2019 2018

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (10 results) (of which Int'l Joint Research: 6 results,  Invited: 4 results)

  • [Journal Article] Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice2022

    • Author(s)
      Hasegawa Emi、Miyasaka Ai、Sakurai Katsuyasu、Cherasse Yoan、Li Yulong、Sakurai Takeshi
    • Journal Title

      Science

      Volume: 375 Issue: 6584 Pages: 994-1000

    • DOI

      10.1126/science.abl6618

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice2022

    • Author(s)
      Emi Hasegawa, Ai Miyasaka, Katsuyasu Sakurai, Yoan Cherasse, Yulong Li, Takeshi Sakurai
    • Organizer
      JST-CREST “Opt Bio” / WPI-IIIS Joint Symposium
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice2022

    • Author(s)
      Emi Hasegawa, Ai Miyasaka, Katsuyasu Sakurai, Yoan Cherasse, Yulong Li, Takeshi Sakurai,
    • Organizer
      WPI-IIIS/Fudan University Joint Symposium
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] レム睡眠関連脱力発作における扁桃体へのドーパミン放出の影響2019

    • Author(s)
      長谷川恵美、前島隆司、吉田隆行、柳沢正史、三枝理博、桜井武
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Neural circuits of cataplexy2019

    • Author(s)
      Emi Hasegawa, Ai Miyasaka, Takashi Maejima, Takayuki Yoshida, Katsuyasu Sakurai, Mitsuhiro Yoshioka, Masashi Yanagisawa, Michihiro Mieda, Takeshi Sakurai
    • Organizer
      World sleep 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Dopamine release into the amygdala might be involved in REM-related muscle atonia2019

    • Author(s)
      Emi Hasegawa, Ai Miyasaka, Takashi Maejima, Takayuki Yoshida, Katsuyasu Sakurai, Mitsuhiro Yoshioka, Masashi Yanagisawa, Michihiro Mieda, Takeshi Sakurai
    • Organizer
      World sleep 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neural circuits of narcolepsy2018

    • Author(s)
      Emi Hasegawa, Takashi Maejima, Takayuki Yoshida, Olivia A. Masseck, Stefan Herlitze, Mitsuhiro Yoshioka, Masashi Yanagisawa, Michihiro Mieda, Takeshi Sakurai
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Neural circuits of narcolepsy2018

    • Author(s)
      Emi Hasegawa, Takashi Maejima, Takayuki Yoshida, Olivia A. Masseck, Stefan Herlitze, Mitsuhiro Yoshioka, Masashi Yanagisawa, Michihiro Mieda, Takeshi Sakurai
    • Organizer
      The 11thFENS Forum of Neuroscience
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 扁桃体へのセロトニン神経入力はオレキシンを介して情動脱力発作の抑制する2018

    • Author(s)
      長谷川恵美、前島隆司、吉田隆行、Olivia Masseck、Stefan Horlitze、吉岡充弘、柳沢正史、三枝理博、櫻井武
    • Organizer
      日本睡眠学会 第43回 定期学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] ナルコレプシーの神経経路の探索2018

    • Author(s)
      長谷川恵美、前島隆司、三枝理博、櫻井武
    • Organizer
      日本睡眠学会 第43回 定期学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Search for neural circuits of narcolepsy-cataplexy2018

    • Author(s)
      Emi Hasegawa, Takashi Maejima, Takayuki Yoshida, Mitsuhiro Yoshioka, Masashi Yanagisawa, Michihiro Mieda, Takeshi Sakurai
    • Organizer
      Society for Neuroscience
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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