Elucidation of mechanisms for directing subcellular localization of reactive oxygen-producing NADPH oxidases in epithelial cells
| Project/Area Number |
18K15047
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 48040:Medical biochemistry-related
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| Research Institution | Kyushu University |
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Principal Investigator |
Kohda Akira 九州大学, 医学研究院, 助教 (10814650)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | NADPHオキシダーゼ / 上皮細胞内局在制御 |
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| Outline of Final Research Achievements |
Transmembrane proteins of the NADPH oxidase (Nox) family exist in various epithelial cells, such as digestive tract, lung, and thyroid, and play a role in host defense and hormone synthesis by producing reactive oxygen species (ROS). Since unregulated production of highly reactive ROS often damage tissues and cells, Nox proteins should function at the specific site in cells. However, the mechanisms for targeting Nox to the precise cellular location have been less understood. In the present study, we showed that one of the Nox binding proteins is essential for determining the subcellular localization of Nox proteins in epithelial cells.
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| Academic Significance and Societal Importance of the Research Achievements |
活性酸素は宿主防御やホルモンの生合成などの生体機能に用いられる一方で、その反応性の高さ故、無秩序な生成は細胞や組織に有害である。実際に、活性酸素の過剰生成は、多くの疾患の病因に関与することが知られる。本研究では、Noxファミリーが細胞内の「適切な場所」で活性酸素を生成するための仕組みの一端を明らかにした。本研究を通じて、生体が厳密に制御された活性酸素生成を行うための新たな分子機構が明らかになった。
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Report
(3 results)
Research Products
(2 results)
