| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
we found that Activin B could improve whole-body glucose metabolisms through modulating both insulin sensitivity and glucose-induced insulin secretion (GSIS). We also found that Activin B could reduce fat mass and improve obesity of obese mice models via stimulating heat production and energy expenditure which depend on FGF21. During glucose tolerance test (GTT), increased insulin secretion was observed in normal lean mice or DIO mice with Inhbb gene transfer despite the improvement of insulin sensitivity. On the other hand, the study using newly established tissue-specific Inhbb gene knockout mice suggested that Activin B is required for physiological GSIS in normal mice.
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