Role of TgGIF in suppression of anti-Toxoplasma immune response
| Project/Area Number |
18K15135
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 49040:Parasitology-related
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| Research Institution | Osaka University |
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Principal Investigator |
Ma Jisu 大阪大学, 微生物病研究所, 助教 (90755266)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | トキソプラズマ / インターフェロン / TgGIF / Gate-16 / IRGB6 / インターフェロンγ |
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| Outline of Final Research Achievements |
Toxoplasma gondii is one of the zoonotic pathogens causing fatal toxoplasmosis in humans and animals. In infected cells, a membrane structure called a parasite is formed, but host immunity produces interferon against this, and the interferon-induced GTPase is accumulated to destroy the parasite and protect the body. On the other hand, highly pathogenic T. gondii has various mechanisms that can suppress the interferon-induced GTPase-dependent immune response, but due to the large number of interferon-induced GTPases, there is no virulence factor for each. , This study found that it targets a factor called Gate-16.
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| Academic Significance and Societal Importance of the Research Achievements |
トキソプラズマはエイズや抗がん剤投与下にある免疫不全者で致死的なトキソプラズマ症を引き起こす病原体である。また妊婦が初感染した場合にも、胎児に垂直感染し、重篤な先天性トキソプラズマ症を引き起こす。トキソプラズマ原虫はヒトを含む全ての恒温動物に感染する病原体であり、感染細胞内では寄生胞と呼ばれる膜の構造体を作り出し、その中で増殖する。我々宿主の免疫系は、インターフェロンと呼ばれる免疫物質を作り出し、それにより誘導される酵素が寄生胞に蓄積することで破壊する。今回の研究では、トキソプラズマがTgGIFと呼ばれる病原性分子を放出して、インターフェロン誘導性酵素を負に制御していることを発見した。
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] CXCR4 regulates Plasmodium development in mouse and human hepatocytes2019
Author(s)
Bando Hironori、Pradipta Ariel、Iwanaga Shiroh、Okamoto Toru、Okuzaki Daisuke、Tanaka Shun、Vega-Rodr?guez Joel、Lee Youngae、Ma Ji Su、Sakaguchi Naoya、Soga Akira、Fukumoto Shinya、Sasai Miwa、Matsuura Yoshiharu、Yuda Masao、Jacobs-Lorena Marcelo、Yamamoto Masahiro
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Journal Title
Journal of Experimental Medicine
Volume: 216
Issue: 8
Pages: 1733-1748
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense.2019
Author(s)
Lee, Y., Yamada, H., Pradipta, A., Ma, J.S., Okamoto, M., Nagaoka, H., Takashima, E., Standley, D.M., Sasai, M., Takei, K., Yamamoto, M.
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Journal Title
Life Science Alliance
Volume: 3
Issue: 1
Pages: 000-000
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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