| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Outline of Final Research Achievements |
The MICs of the Helicobacter cinaedi isolates were determined by the broth microdilution method. For resistant strains, mutations were detected by analyzing resistance-related genes. By comparing the amino acid sequences of the drug efflux system, we found that a certain point mutation is involved in the development of high drug resistance.
We focused on the type IV secretion system (T6SS) gene cluster for the pathogenicity of H. cinaedi. T6SS was involved in infecting host cells. Furthermore, a T6SS effector candidate protein was detected. The proteins inhibited bacterial growth.
|
