Regulation of dendritic cells and lymphoid tissues by CD47-SIRPalpha signaling
| Project/Area Number |
18K15190
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 49070:Immunology-related
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 樹状細胞 / ストローマ細胞 / 自己免疫疾患 / SIRPα / CD47 / 自己免疫性疾患 |
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| Outline of Final Research Achievements |
We investigated the regulatory mechanism how dendritic cells (DCs) mediates lymphoid tissue reconstitution, as well as regulates the pathogenesis of autoimmune diseases, by the CD47-SIRPα signaling. We found that SIRPα signaling is important for DC-induced maintenance of stromal cells in vivo, as wll as for the reconstitution of lymphoid tissue. Furthermore, we found that SIRPα and CD47 on DCs regulate the priming of self-reactive T cells in the peripheral lymphoid tissue and the subsequent infiltration or reactivation of inflammatory cells into the central nervous system in an experimental autoimmune encephalomyelitis model.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果により、自己免疫疾患の発症やリンパ組織ストローマ細胞の再構築において新たな作用機序の解明をもたらすことから、各種免疫疾患（自己免疫疾患、感染症、移植免疫）や腫瘍免疫応答に対する革新的な診断や治療技術開発などの新たな創造をもたらすことが期待される。
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] An animal model that mimics human herpesvirus 6B pathogenesis2019
Author(s)
Wang B, Saito Y, Nishimura M, Ren Z, Tjan LH, Refaat A, Iida-Norita R, Tsukamoto R, Komatsu M, Itoh T, Matozaki T, Mori Y
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Journal Title
Journal of Virology
Volume: 94
Issue: 6
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Microglial SIRPα regulates the emergence of CD11c+ microglia and demyelination damage in white matter.2019
Author(s)
Sato-Hashimoto M, Nozu T, Toriba R, Horikoshi A, Akaike M, Kawamoto K, Hirose A, Hayashi H, Nagai H, Shimizu W, Saiki A., Ishikawa T, Elhanbaly R, Kotani T, Murata Y, Saito Y, Naruse M, Shibasaki K, Oldenborg P.-A, Jung S, Matozaki T, Fukazawa Y, Ohnishi H.
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Journal Title
eLife
Volume: -
Pages: 1-29
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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