• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Subnuclear genome organization for cell-type specific cancer development

Research Project

Project/Area Number 18K15210
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 50010:Tumor biology-related
Research InstitutionThe University of Tokyo

Principal Investigator

Ito Kenji  東京大学, 医科学研究所, 特任研究員 (20757504)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsゲノム核内構造 / 遺伝子変異 / 発がん / エピジェネティクス / 老化 / 核内構造 / がん / 発がんモデル
Outline of Final Research Achievements

During the period of this research project, we established a doxycycline-inducible clear cell sarcoma model mouse capable of inducing oncogene expression in various types of tissue. By using this mouse, we uncovered (1) Oncogene Induced Senescence (OIS) has occurred in most cell types, and (2) avoidance of OIS and cancer development have occurred only in soft tissue. We also clarified that the change in chromatin structure formed by the transcription factor expressed in the cell of origin of clear cell sarcoma is the mechanism behind the tissue-specific cancer development. This work was published from Nature Communications (Komura S *, Ito K *, Nature Com., 2019).

Academic Significance and Societal Importance of the Research Achievements

近年、細胞老化は発がんの抑制に関与しうる事が報告されている。したがって、本研究成果はゲノム核内構造の変換を伴うクロマチン構造の変化に着目し、それをマウス個体内で誘導する事で細胞老化を誘導し、発がんを抑制出来る可能性を示したという点において意義深いと言える。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas2019

    • Author(s)
      Komura S, Ito Kenji、Ohta ShoUkai Tomoyo、Kabata Mio、Itakura Fumiaki、Semi Katsunori、Matsuda Yutaka、Hashimoto Kyoichi、Shibata Hirofumi、Sone Masamitsu、Jo Norihide、Sekiguchi Kazuya、Ohno Takatoshi、Akiyama Haruhiko、Shimizu Katsuji、Woltjen Knut、Ozawa Manabu、Toguchida Junya、Yamamoto Takuya、Yamada Yasuhiro
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 3999-3999

    • DOI

      10.1038/s41467-019-11745-1

    • NAID

      120006719352

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Cancer drug screening based on refractoriness of cancer cell reprogramming.2019

    • Author(s)
      Ito K, Matsuda Y, Yamada K, Matsumoto T, Ohta A, Woltjen K, Yamada Y
    • Organizer
      Keystone Symposia on Cellular Plasticity: Reprogramming, Regeneration and Metaplasia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cancer drug screening based on refractoriness of cancer cell reprogramming2019

    • Author(s)
      Ito K, Yamada Y
    • Organizer
      第92回日本生化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Cancer drug screening based on refractoriness of cancer cell reprogramming2019

    • Author(s)
      Kenji Ito, Akira Ohta, Knut Woltjen, Yasuhiro Yamada
    • Organizer
      Keystone Symposia Conference : Cellular Plasticity: Reprogramming, Regeneration and Metaplasia
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cancer drug screening based on refractoriness of cancer cell reprogramming2018

    • Author(s)
      Kenji Ito, Akira Ohta, Knut Woltjen, Yasuhiro Yamada
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Book] 医学のあゆみ2019

    • Author(s)
      伊藤 謙治、山田泰広
    • Total Pages
      6
    • Publisher
      医歯薬出版
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi