Revealing the function and the molecular network of a novel lncRNA associated with gastric cancer and gastritis
| Project/Area Number |
18K15220
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 50010:Tumor biology-related
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 胃がん / 長鎖non-coding RNA / ストレス顆粒 / lncRNA / 慢性炎症 / 炎症 |
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| Outline of Final Research Achievements |
Gastric cancers (GCs) develop through Helicobacter Pylori-induced chronic gastritis. The involvement of long noncoding RNAs (lncRNAs) in inflammation-related carcinogenesis remains unclear. We have identified a lncRNA TM4SF1AS1, which promotes GC cell proliferation and tumor formation. To unravel pathways and molecular networks associated with TM4SF1AS1 in the tumorigenesis, we comprehensively screened a series of TM4SF1AS1-binding proteins. We identified many stress granule-associated molecules and found that TM4SF1AS1 promoted stress granule-like bodyformation in GC cells. Moreover, TM4SF1AS1 inhibited apoptosis mediated by stress-responsive MAPK. It suggested that TM4SF1AS1 might be a lncRNA link between tumorigenesis and stress granule and a potential therapeutic target.
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| Academic Significance and Societal Importance of the Research Achievements |
これまでlncRNA研究において慢性炎症とがんに関わるlncRNAの報告は少なく、 TM4SF1AS1のようにストレス顆粒と発がんを結びつけるlncRNAの報告はない。また、TM4SF1AS1の阻害は胃がんのみならず他のがん細胞においても細胞増殖の抑制効果があることを確認している。TM4SF1AS1のがん遺伝子的機能とその作用機序は、様々ながんに共通する可能性があり、新たながん治療標的分子となりうることが今後期待される。以上より、本研究の成果は学術的にも社会的にも意義は高いものと考える。
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Dual EZH2 and G9a inhibition suppresses multiple myeloma cell proliferation by regulating the interferon signal and IRF4-MYC axis.2021
Author(s)
Ishiguro K, Kitajima H, Niinuma T, Maruyama R, Nishiyama N, Ohtani H, Sudo G, Toyota M, Sasaki H, Yamamoto E, Kai M, Nakase H, Suzuki H.
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Journal Title
Cell Death Discovery
Volume: 7
Issue: 1
Pages: 7-7
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Subtypes of the Type II Pit Pattern Reflect Distinct Molecular Subclasses in the Serrated Neoplastic Pathway.2018
Author(s)
Aoki H, Yamamoto E, Yamano HO, Sugai T, Kimura T, Tanaka Y, Matsushita HO, Yoshikawa K, Takagi R, Harada E, Nakaoka M, Yoshida Y, Harada T, Sudo G, Eizuka M, Yorozu A, Kitajima H, Niinuma T, Kai M, Nojima M, Suzuki H, Nakase H.
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Journal Title
Dig Dis Sci.
Volume: 15
Issue: 7
Pages: 1920-1928
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Dysregulation of miRNA in chronic hepatitis B is associated with hepatocellular carcinoma risk after nucleos(t)ide analogue treatment2018
Author(s)
Wakasugi H, Takahashi H, Niinuma T, Kitajima H, Oikawa R, Matsumoto N, Takeba Y, Otsubo T, Takagi M, Ariizumi Y, Suzuki M, Okuse C, Iwabuchi S, Nakano M, Akutsu N, Kang JH, Matsui T, Yamada N, Sasaki H, Yamamoto E, Kai M, Sasaki Y, Sasaki, Tanaka, Yotsuyanagi, Tsutsumi, Yamamoto, Tokino T , Nakase H, Suzuki H, Itoh F
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Journal Title
Cancer Letters
Volume: 434
Pages: 91-100
DOI
Related Report
Peer Reviewed
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