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Novel approach with chemoradiotherapy for bone metastasis on breast cancer

Research Project

Project/Area Number 18K15318
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 50020:Tumor diagnostics and therapeutics-related
Research InstitutionOsaka University

Principal Investigator

MINAMI KAZUMASA  大阪大学, 医学系研究科, 寄附講座助教 (90634593)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsがん転移 / 乳がん / X線 / 炭素イオン線 / ドーパミンレセプター / 骨転移 / LRP5 / 陽子線
Outline of Final Research Achievements

In this study, we investigated whether radiation and dopamine receptor-targeted drugs, which have different mechanisms of action, are significantly anti-tumor and anti-metastatic compared to conventional therapies for breast cancer. In cell experiments, the combination of radiation and dopamine receptor-targeted drugs significantly inhibited the cell survival, motility and invasion. Furthermore, in animal experiments, the antitumor and distant metastasis inhibitory effects were observed as well as in vitro study.
In conclusion, the significance of the combination of radiation and dopamine receptor-targeted drugs in the treatment of breast cancer was demonstrated.

Academic Significance and Societal Importance of the Research Achievements

乳がんは罹患する年齢が特徴的であり、30代前半から増加し始め40代後半から50代前半でピークを迎える。これは正に子育て世代から働き盛りの世代を直撃するがんであり、社会への打撃も大きい。ステージⅣとなると5年生存率が30%程度まで落ちる。中でも、乳がんの骨転移は比較的発生しやすく痛みを伴うことから患者のQuality of life (QOL) を著しく低下させる。よって、乳がんの骨転移抑制を視野に入れた治療法の確立が課題である。
本研究課題により、放射線とdopamine receptor標的薬の併用が骨吸収抑制を行いつつ、一定の抗腫瘍効果ならびに転移抑制効果が得られる事が示された。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (16 results)

All 2020 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (8 results) (of which Int'l Joint Research: 6 results,  Invited: 2 results)

  • [Int'l Joint Research] IUPUI(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] IUPUI(米国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Pitavastatin slows tumor progression and alters urine-derived volatile organic compounds through the mevalonate pathway2019

    • Author(s)
      Wang Luqi、Wang Yue、Chen Andy、Teli Meghana、Kondo Rika、Jalali Aydin、Fan Yao、Liu Shengzhi、Zhao Xinyu、Siegel Amanda、Minami Kazumasa、Agarwal Mangilal、Li Bai-Yan、Yokota Hiroki
    • Journal Title

      The FASEB Journal

      Volume: 33 Issue: 12 Pages: 13710-13721

    • DOI

      10.1096/fj.201901388r

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Carbon ion irradiation enhances the antitumor efficacy of dual immune checkpoint blockade therapy both for local and distant sites in murine osteosarcoma2018

    • Author(s)
      Takahashi Yutaka、Yasui Tomohiro、Minami Kazumasa、Tamari Keisuke、Hayashi Kazuhiko、Otani Keisuke、Seo Yuji、Isohashi Fumiaki、Koizumi Masahiko、Ogawa Kazuhiko
    • Journal Title

      Oncotarget

      Volume: 10 Issue: 6 Pages: 9364-9378

    • DOI

      10.18632/oncotarget.26551

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Radiobiological effects of flattening filter?free photon beams on A549 non-small-cell lung cancer cells2018

    • Author(s)
      Nakano Hisashi、Minami Kazumasa、Yagi Masashi、Imaizumi Hiromasa、Otani Yuki、Inoue Shinichi、Takashina Masaaki、Seo Yuji、Takahashi Yutaka、Sumida Iori、Ogawa Kazuhiko、Koizumi Masahiko
    • Journal Title

      Journal of Radiation Research

      Volume: 59 Issue: 4 Pages: 442-445

    • DOI

      10.1093/jrr/rry041

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mesothelial cells facilitate cancer stem-like properties in spheroids of ovarian cancer cells.2018

    • Author(s)
      Shishido A, Mori S, Yokoyama Y, Hamada Y, Minami K, Qian Y, Wang J, Hirose H, Wu X, Kawaguchi N, Nagumo S, Matsuura N, Yamamoto H.
    • Journal Title

      Oncol Rep

      Volume: 4 Pages: 2105-2114

    • DOI

      10.3892/or.2018.6605

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Finite-element analysis of the mouse proximal ulna in response to elbow loading.2018

    • Author(s)
      Jiang F, Jalali A, Deguchi C, Chen A, Liu S, Kondo R, Minami K, Horiuchi T, Li BY, Robling AG, Chen J, Yokota H.
    • Journal Title

      J Bone Miner Metab.

      Volume: e-pub ahead of print Issue: 3 Pages: 419-429

    • DOI

      10.1007/s00774-018-0943-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Osteocyte-Driven Downregulation of Snail Restrains Effects of Drd2 Inhibitors on Mammary Tumor Cells.2018

    • Author(s)
      Liu S, Fan Y, Chen A, Jalali A, Minami K, Ogawa K, Nakshatri H, Li BY, Yokota H.
    • Journal Title

      Cancer Res.

      Volume: 78(14) Issue: 14 Pages: 3865-3876

    • DOI

      10.1158/0008-5472.can-18-0056

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 骨刺激によるドーパミン経路調節が乳がん転移性脳腫瘍に与える影響2020

    • Author(s)
      皆巳和賢、近藤梨加、高橋美智子、中田麻友、高橋豊、玉利慶介、瀬尾雄二、鈴木修、礒橋文明、小泉雅彦、小川和彦
    • Organizer
      第22回 菅原・大西記念 癌治療増感研究シンポジウム in 奈良
    • Related Report
      2019 Annual Research Report
  • [Presentation] Combination therapy using a dopamine receptor D1 agonist and carbon ion beam inhibit mammary tumor growth and bone metastatic potentials.2019

    • Author(s)
      Minami K, Kondo R, Koizumi M, Ogawa K.
    • Organizer
      58th AnnualConference of the Particle Therapy Co-Operative Group
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The combination therapy using Pitavastatin and carbon ion beam inhibit metastatic potentials on mammary tumor cells.2019

    • Author(s)
      Kondo R, Minami K, Koizumi M.
    • Organizer
      58th AnnualConference of the Particle Therapy Co-Operative Group,
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 線質、線量の違いによる細胞遊走・浸潤能に与える影響2019

    • Author(s)
      皆巳 和賢、高橋 豊、玉利 慶介、瀬尾 雄二、大谷 啓祐、鈴木 修、礒橋 文明、小泉 雅彦、小川 和彦
    • Organizer
      第21回 菅原・大西記念癌治療増感研究シンポジウム
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Combination therapy using a dopamine receptor D1 agonist and radiation inhibit mammary tumor growth and bone metastatic potentials.2019

    • Author(s)
      Kazumasa Minami, Yutaka Takahashi, Keisuke Tamari, Yuji Seo, Keisuke Otani, Osamu Suzuki, Fumiaki Isohashi, Kazuhiko Ogawa.
    • Organizer
      第9回 国際放射線神経生物学会
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comparison of the effect of X-ray, carbon ion beam and proton beam on metastatic potential.2018

    • Author(s)
      Kondo R, Adachi T, Minami K, Koizumi M.
    • Organizer
      PTCOG 57th
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 乳がん細胞におけるChk1 inhibitorと 放射線併用によるがん転移能への影響2018

    • Author(s)
      足立 孝則、皆巳 和賢、近藤 梨加、小泉 雅彦
    • Organizer
      第24回 癌治療増感研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] Comparison of the effect of photon and particle beam on metastatic potentials.2018

    • Author(s)
      Minami K
    • Organizer
      GICore summer school 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2018-04-23   Modified: 2021-02-19  

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