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Translational research on brain aging and its modifiable factors using human and animal MRI

Research Project

Project/Area Number 18K15410
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52010:General internal medicine-related
Research InstitutionTohoku University

Principal Investigator

Suzuki Hideaki  東北大学, 大学病院, 助教 (20705462)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsMRI / 脳 / UKバイオバンク / 加齢 / 生活習慣病 / 老化 / 認知症 / 高齢者 / ビッグデータ / バイオバンク
Outline of Final Research Achievements

In Clinical Study 1: Associations of aging and lifestyle disease with brain health, we reported that lower grey matter volume (GMV) associated with lifestyle diseases (ie, hypertension, diabetes, obesity, and frequent alcohol use) mapped within the larger volumes showing GMV differences associated with age. Moreover, aging and these lifestyle diseases had additive associations with lower GMV in the brain regions as early pathology of Alzheimer's disease (AD).

In Clinical Study 2: Exploration of new modifiable factors for brain aging, we reported that higher heart rate was associated with volume of the dementia-related brain regions. In Animal experiment, we are now preparing for the draft submitted to a scientific journal.

Academic Significance and Societal Importance of the Research Achievements

臨床研究1.の研究結果から、認知症の無い症例における加齢・生活習慣病と認知症発症との関連が、また臨床研究1.の研究結果から、頻脈は脳の老化の新たな修飾可能因子である可能性が示唆された。

これらの研究結果から、患者数が増加している認知症が発症する過程おいて、認知症の無い時期における加齢・生活習慣病の意義が再確認されると共に、生活習慣病予防に加え頻脈に対する介入が認知症予防に役立つ可能性が考えられる。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (29 results)

All 2020 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (14 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 14 results,  Open Access: 7 results) Presentation (12 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Int'l Joint Research] Imperial College London(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Imperial College London(英国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Impacts of hippocampal blood flow on changes in left ventricular wall thickness in patients with chronic heart failure2020

    • Author(s)
      Suzuki Hideaki, Matsumoto Yasuharu, Sugimura Koichiro, Takahashi Jun, Miyata Satoshi, Fukumoto Yoshihiro, Taki Yasuyuki, Shimokawa Hiroaki
    • Journal Title

      International Journal of Cardiology

      Volume: 310 Pages: 103

    • DOI

      10.1016/j.ijcard.2020.01.019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcatheter aortic valve implantation and cognitive function in elderly patients with severe aortic stenosis2020

    • Author(s)
      Tsuchiya S, Matsumoto Y, Suzuki H, Takanami K, Kikuchi Y, Takahashi J, Miyata S, Tomita N, Kumagai K, Taki Y, Saiki Y, Arai H, Shimokawa H.
    • Journal Title

      EuroIntervention

      Volume: 15 Issue: 18 Pages: e1580-e1587

    • DOI

      10.4244/eij-d-19-00489

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Large-scale Quality Control of Cardiac Imaging in Population Studies: Application to UK Biobank2020

    • Author(s)
      Tarroni Giacomo, Bai Wenjia, Oktay Ozan, Schuh Andreas, Suzuki Hideaki, Glocker Ben, Matthews Paul M, Rueckert Daniel
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 2408-2408

    • DOI

      10.1038/s41598-020-58212-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cyclophilin A as a biomarker for the therapeutic effect of balloon angioplasty in chronic thromboembolic pulmonary hypertension2020

    • Author(s)
      Kozu K, Satoh K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Shimizu T, Sato H, Konno R, Terui Y, Nochioka K, Kikuchi N, Satoh T, Sugimura K, Miyata S, Shimokawa H.
    • Journal Title

      J Cardiol

      Volume: 75 Issue: 4 Pages: 415

    • DOI

      10.1016/j.jjcc.2019.09.010

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treadmill exercise prevents reduction of bone mineral density after myocardial infarction in apolipoprotein E-deficient mice.2019

    • Author(s)
      Masanori Kanazawa, Yasuharu Matsumoto, Kikuyo Takahashi, Hideaki Suzuki, Hironori Uzuka, Kensuke Nishimiya, Hiroaki Shimokawa.
    • Journal Title

      European Journal of Preventive Cardiology

      Volume: in press Issue: 1 Pages: 28-35

    • DOI

      10.1177/2047487319834399

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Associations of Regional Brain Structural Differences With Aging, Modifiable Risk Factors for Dementia, and Cognitive Performance2019

    • Author(s)
      Suzuki Hideaki, Venkataraman Ashwin V, Bai Wenjia, Guitton Florian, Guo Yike, Dehghan Abbas, Matthews Paul M for the Alzheimer’s Disease Neuroimaging Initiative
    • Journal Title

      JAMA Network Open

      Volume: 2 Issue: 12 Pages: e1917257-e1917257

    • DOI

      10.1001/jamanetworkopen.2019.17257

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic value of the model for end-stage liver disease excluding INR score (MELD-XI) in patients with adult congenital heart disease2019

    • Author(s)
      Konno R, Tatebe S, Sugimura K, Satoh K, Aoki T, Miura M, Suzuki H, Yamamoto S, Sato H, Terui Y, Miyata S, Adachi O, Kimura M, Saiki Y, Shimokawa H.
    • Journal Title

      PLoS One

      Volume: 14 Issue: 11 Pages: 0225403-0225403

    • DOI

      10.1371/journal.pone.0225403

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Automated quality control in image segmentation: application to the UK Biobank cardiovascular magnetic resonance imaging study.2019

    • Author(s)
      Robert Robinson, Vanya V. Valindria, Wenjia Bai, Ozan Oktay, Bernhard Kainz, Hideaki Suzuki, et al.
    • Journal Title

      Journal of Cardiovascular Magnetic Resonance

      Volume: 21 Issue: 1 Pages: 18-18

    • DOI

      10.1186/s12968-019-0523-x

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders2019

    • Author(s)
      Evangelou Evangelos, Gao He, Chu Congying, Ntritsos Georgios, Blakeley Paul, Butts Andrew R, Pazoki Raha, Suzuki Hideaki et al.
    • Journal Title

      Nature Human Behaviour

      Volume: 3 Issue: 9 Pages: 950-961

    • DOI

      10.1038/s41562-019-0653-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Learning-Based Quality Control for Cardiac MR Images.2019

    • Author(s)
      Tarroni Giacomo, Oktay Ozan, Bai Wenjia, Schuh Andreas, Suzuki Hideaki, Passerat-Palmbach Jonathan, de Marvao Antonio, O'Regan Declan P, Cook Stuart, Glocker Ben, Matthews Paul M, Rueckert Daniel.
    • Journal Title

      IEEE Transactions on Medical Imaging

      Volume: in press Issue: 5 Pages: 1127-1138

    • DOI

      10.1109/tmi.2018.2878509

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Recurrent neural networks for aortic image sequence segmentation with sparse annotations.2018

    • Author(s)
      Wenjia Bai, Hideaki Suzuki, Chen Qin, Giacomo Tarroni, Ozan Oktay, Paul M. Matthews, Daniel Rueckert.
    • Journal Title

      Medical Image Computing and Computer Assisted Intervention

      Volume: 11073 Pages: 586-594

    • DOI

      10.1007/978-3-030-00937-3_67

    • ISBN
      9783030009366, 9783030009373
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Comprehensive approach for learning-based fully-automated inter-slice motion correction for short-axis cine cardiac MR image stacks.2018

    • Author(s)
      Giacomo Tarroni, Ozan Oktay, Matthew Sinclair, Wenjia Bai, Andreas Schuh, Hideaki Suzuki, Antonio de Marvao, Declan O’Regan, Stuart Cook, Daniel Rueckert.
    • Journal Title

      Medical Image Computing and Computer Assisted Intervention

      Volume: 11070 Pages: 268-276

    • DOI

      10.1007/978-3-030-00928-1_31

    • ISBN
      9783030009274, 9783030009281
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Automated cardiovascular magnetic resonance image analysis with fully convolutional networks.2018

    • Author(s)
      Wenjia Bai, Matthew Sinclair, Giacomo Tarroni, Ozan Oktay, Martin Rajchl, Ghislain Vaillant, Aaron M. Lee, Nay Aung, Elena Lukaschuk, Mihir M. Sanghvi, Filip Zemrak, Kenneth Fung, Jose Miguel Paiva, Valentina Carapella, Young Jin Kim, Hideaki Suzuki, et al.
    • Journal Title

      Journal of Cardiovascular Magnetic Resonance

      Volume: 20 Issue: 1 Pages: 65-65

    • DOI

      10.1186/s12968-018-0471-x

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structural brain abnormalities and cardiac dysfunction in patients with chronic heart failure2018

    • Author(s)
      Hideaki Suzuki, Yasuharu Matsumoto, Hideki Ota, Koichiro Sugimura, Jun Takahashi, Kenta Ito, Satoshi Miyata, Yoshihiro Fukumoto, Yasuyuki Taki, Hiroaki Shimokawa.
    • Journal Title

      European Journal of Heart Failure

      Volume: 20 Issue: 5 Pages: 936

    • DOI

      10.1002/ejhf.1104

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Impacts of hippocampal blood flow on cardiac remodeling in patients with chronic heart failure2019

    • Author(s)
      Suzuki Hideaki, Matsumoto Yasuharu, Sugimura Koichiro, Takahashi Jun, Miyata Satoshi, Fukumoto Yoshihiro, Arai Hiroyuki, Taki Yasuyuki, Shimokawa Hiroaki
    • Organizer
      2019年度欧州心臓病学会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evidence for improved cognitive function following transcatheter aortic valve implantation in elderly patients with severe aortic stenosis - Brain perfusion SPECT imaging study2019

    • Author(s)
      Tsuchiya Satoshi, Matsumoto Yasuharu, Kikuchi Yoku, Sugisawa Jun, Hao Kiyotaka, Takeuchi Masashi, Takahashi Jun, Kawamoto Shunsuke, Kumagai Kiichiro, Wagatsuma Toshihiro, Saiki Yoshikatsu, Shimokawa Hiroaki
    • Organizer
      2019年度欧州心臓病学会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 疣贅と類似した構造物を認めた、粘液腫様変性に伴う急性大動脈弁閉鎖不全症の一例2019

    • Author(s)
      佐藤匠、鈴木秀明、佐藤遥、矢尾板信裕、山本沙織、福井重文、建部俊介、杉村宏一郎、下川宏明
    • Organizer
      第169回日本循環器学会東北地方会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Usefulness of Regional Wall Thickening Pattern for Differential Diagnosis of Cardiac Diseases with LV Hypertrophy -A Novel Deep-learning-based CMR System-2019

    • Author(s)
      Yamamoto Saori, Suzuki Hideaki, Bai Wenjia, Sugimura Koichiro, Tatebe Shunsuke, Aoki Tatsuo, Miura Masanobu, Sato Haruka, Konno Ryo, Terui Yosuke, Sakota Miku, Ota Hideki, Takanami Kentaro, Takase Kei, Nochioka Kotaro, Satoh Kimio, Shimokawa Hiroaki
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Transcatheter Aortic Valve Implantation Increases Regional Brain Perfusion Associated with Cognitive Improvement in Elderly Patients with Severe Aortic Stenosis2019

    • Author(s)
      Satoshi Tsuchiya, Yasuharu Matsumoto, Hideaki Suzuki, Jun Sugisawa, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Jun Takahashi, Kiichiro Kumagai, Yoshikatsu Saiki, Hiroaki Shimokawa
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Brain Areas Associated with Future Exacerbation of Heart Failure Symptoms2019

    • Author(s)
      Suzuki Hideaki, Matsumoto Yasuharu, Sugimura Koichiro, Takahashi Jun, Miyata Satoshi, Fukumoto Yoshihiro, Taki Yasuyuki, Shimokawa Hiroaki
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Brain Areas Associated with Future Exacerbation of Heart Failure Symptoms.2019

    • Author(s)
      Hideaki Suzuki, Yasuharu Matsumoto, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Yoshihiro Fukumoto, Yasuyuki Taki, Hiroaki Shimokawa.
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Usefulness of Regional Wall Thickening Pattern for Differential Diagnosis of Cardiac Diseases with LV Hypertrophy -A Novel Deep-learning-based CMR System-.2019

    • Author(s)
      Saori Yamamoto, Hideaki Suzuki, Wenjia Bai, Koichiro Sugimura, Shunsuke Tatebe, Tatsuo Aoki, Masanobu Miura, Haruka Sato, Ryo Konno, Yosuke Terui, Miku Sakota, Hideki Ota, Kentaro Takanami, Kei Takase, Kotaro Nochioka, Kimio Satoh, Hiroaki Shimokawa.
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Transcatheter Aortic Valve Implantation Increases Regional Brain Perfusion Associated with Cognitive Improvement in Elderly Patients with Severe Aortic Stenosis.2019

    • Author(s)
      Satoshi Tsuchiya, Yasuharu Matsumoto, Hideaki Suzuki, Jun Sugisawa, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Jun Takahashi, Kiichiro Kumagai, Yoshikatsu Saiki, Hiroaki Shimokawa.
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Heart rate as a novel risk factor for brain health.2018

    • Author(s)
      Hideaki Suzuki, Paul M. Matthews.
    • Organizer
      European Society for Cardiology Congress 2018
    • Related Report
      2018 Research-status Report
  • [Presentation] Relative impacts of aging and modifiable risk factors for dementia on brain volumes in the UK Biobank cohort.2018

    • Author(s)
      Hideaki Suzuki, Paul M. Matthews.
    • Organizer
      The Alzheimer's Association International Conference 2018
    • Related Report
      2018 Research-status Report
  • [Presentation] Brain imaging phenotypes in UK Biobank.2018

    • Author(s)
      Hideaki Suzuki, Paul M. Matthews.
    • Organizer
      The International Stroke Genetics Consortium 2018
    • Related Report
      2018 Research-status Report
  • [Book] たこつぼ症候群における脳心連関2020

    • Author(s)
      鈴木秀明、松本泰治、下川宏明
    • Total Pages
      6
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2021-02-19  

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