Translational research on brain aging and its modifiable factors using human and animal MRI
Project/Area Number |
18K15410
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 52010:General internal medicine-related
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2018-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | MRI / 脳 / UKバイオバンク / 加齢 / 生活習慣病 / 老化 / 認知症 / 高齢者 / ビッグデータ / バイオバンク |
Outline of Final Research Achievements |
In Clinical Study 1: Associations of aging and lifestyle disease with brain health, we reported that lower grey matter volume (GMV) associated with lifestyle diseases (ie, hypertension, diabetes, obesity, and frequent alcohol use) mapped within the larger volumes showing GMV differences associated with age. Moreover, aging and these lifestyle diseases had additive associations with lower GMV in the brain regions as early pathology of Alzheimer's disease (AD).
In Clinical Study 2: Exploration of new modifiable factors for brain aging, we reported that higher heart rate was associated with volume of the dementia-related brain regions. In Animal experiment, we are now preparing for the draft submitted to a scientific journal.
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Academic Significance and Societal Importance of the Research Achievements |
臨床研究1.の研究結果から、認知症の無い症例における加齢・生活習慣病と認知症発症との関連が、また臨床研究1.の研究結果から、頻脈は脳の老化の新たな修飾可能因子である可能性が示唆された。
これらの研究結果から、患者数が増加している認知症が発症する過程おいて、認知症の無い時期における加齢・生活習慣病の意義が再確認されると共に、生活習慣病予防に加え頻脈に対する介入が認知症予防に役立つ可能性が考えられる。
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Transcatheter aortic valve implantation and cognitive function in elderly patients with severe aortic stenosis.2020
Author(s)
Tsuchiya S, Matsumoto Y, Suzuki H, Takanami K, Kikuchi Y, Takahashi J, Miyata S, Tomita N, Kumagai K, Taki Y, Saiki Y, Arai H, Shimokawa H.
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Journal Title
EuroIntervention
Volume: 15
Issue: 18
Pages: e1580-e1587
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cyclophilin A as a biomarker for the therapeutic effect of balloon angioplasty in chronic thromboembolic pulmonary hypertension.2020
Author(s)
Kozu K, Satoh K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Shimizu T, Sato H, Konno R, Terui Y, Nochioka K, Kikuchi N, Satoh T, Sugimura K, Miyata S, Shimokawa H.
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Journal Title
J Cardiol
Volume: 75
Issue: 4
Pages: 415-423
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prognostic value of the model for end-stage liver disease excluding INR score (MELD-XI) in patients with adult congenital heart disease.2019
Author(s)
Konno R, Tatebe S, Sugimura K, Satoh K, Aoki T, Miura M, Suzuki H, Yamamoto S, Sato H, Terui Y, Miyata S, Adachi O, Kimura M, Saiki Y, Shimokawa H.
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Journal Title
PLoS One
Volume: 14
Issue: 11
Pages: 0225403-0225403
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Learning-Based Quality Control for Cardiac MR Images.2019
Author(s)
Tarroni Giacomo, Oktay Ozan, Bai Wenjia, Schuh Andreas, Suzuki Hideaki, Passerat-Palmbach Jonathan, de Marvao Antonio, O'Regan Declan P, Cook Stuart, Glocker Ben, Matthews Paul M, Rueckert Daniel.
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Journal Title
IEEE Transactions on Medical Imaging
Volume: in press
Issue: 5
Pages: 1127-1138
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] A Comprehensive approach for learning-based fully-automated inter-slice motion correction for short-axis cine cardiac MR image stacks.2018
Author(s)
Giacomo Tarroni, Ozan Oktay, Matthew Sinclair, Wenjia Bai, Andreas Schuh, Hideaki Suzuki, Antonio de Marvao, Declan O’Regan, Stuart Cook, Daniel Rueckert.
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Journal Title
Medical Image Computing and Computer Assisted Intervention
Volume: 11070
Pages: 268-276
DOI
ISBN
9783030009274, 9783030009281
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Automated cardiovascular magnetic resonance image analysis with fully convolutional networks.2018
Author(s)
Wenjia Bai, Matthew Sinclair, Giacomo Tarroni, Ozan Oktay, Martin Rajchl, Ghislain Vaillant, Aaron M. Lee, Nay Aung, Elena Lukaschuk, Mihir M. Sanghvi, Filip Zemrak, Kenneth Fung, Jose Miguel Paiva, Valentina Carapella, Young Jin Kim, Hideaki Suzuki, et al.
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Journal Title
Journal of Cardiovascular Magnetic Resonance
Volume: 20
Issue: 1
Pages: 65-65
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Evidence for improved cognitive function following transcatheter aortic valve implantation in elderly patients with severe aortic stenosis - Brain perfusion SPECT imaging study2019
Author(s)
Tsuchiya Satoshi, Matsumoto Yasuharu, Kikuchi Yoku, Sugisawa Jun, Hao Kiyotaka, Takeuchi Masashi, Takahashi Jun, Kawamoto Shunsuke, Kumagai Kiichiro, Wagatsuma Toshihiro, Saiki Yoshikatsu, Shimokawa Hiroaki
Organizer
2019年度欧州心臓病学会
Related Report
Int'l Joint Research
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[Presentation] Usefulness of Regional Wall Thickening Pattern for Differential Diagnosis of Cardiac Diseases with LV Hypertrophy -A Novel Deep-learning-based CMR System-2019
Author(s)
Yamamoto Saori, Suzuki Hideaki, Bai Wenjia, Sugimura Koichiro, Tatebe Shunsuke, Aoki Tatsuo, Miura Masanobu, Sato Haruka, Konno Ryo, Terui Yosuke, Sakota Miku, Ota Hideki, Takanami Kentaro, Takase Kei, Nochioka Kotaro, Satoh Kimio, Shimokawa Hiroaki
Organizer
第83回日本循環器学会学術集会
Related Report
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[Presentation] Transcatheter Aortic Valve Implantation Increases Regional Brain Perfusion Associated with Cognitive Improvement in Elderly Patients with Severe Aortic Stenosis2019
Author(s)
Satoshi Tsuchiya, Yasuharu Matsumoto, Hideaki Suzuki, Jun Sugisawa, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Jun Takahashi, Kiichiro Kumagai, Yoshikatsu Saiki, Hiroaki Shimokawa
Organizer
第83回日本循環器学会学術集会
Related Report
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[Presentation] Usefulness of Regional Wall Thickening Pattern for Differential Diagnosis of Cardiac Diseases with LV Hypertrophy -A Novel Deep-learning-based CMR System-.2019
Author(s)
Saori Yamamoto, Hideaki Suzuki, Wenjia Bai, Koichiro Sugimura, Shunsuke Tatebe, Tatsuo Aoki, Masanobu Miura, Haruka Sato, Ryo Konno, Yosuke Terui, Miku Sakota, Hideki Ota, Kentaro Takanami, Kei Takase, Kotaro Nochioka, Kimio Satoh, Hiroaki Shimokawa.
Organizer
第83回日本循環器学会学術集会
Related Report
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[Presentation] Transcatheter Aortic Valve Implantation Increases Regional Brain Perfusion Associated with Cognitive Improvement in Elderly Patients with Severe Aortic Stenosis.2019
Author(s)
Satoshi Tsuchiya, Yasuharu Matsumoto, Hideaki Suzuki, Jun Sugisawa, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Jun Takahashi, Kiichiro Kumagai, Yoshikatsu Saiki, Hiroaki Shimokawa.
Organizer
第83回日本循環器学会学術集会
Related Report
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