• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Biomarkers of Multiple System Atrophy Focusing on Oligodendroglia

Research Project

Project/Area Number 18K15442
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52020:Neurology-related
Research InstitutionNiigata University

Principal Investigator

Tokutake Takayoshi  新潟大学, 医歯学総合病院, 助教 (00707838)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords多系統萎縮症 / バイオマーカー / 脳脊髄液 / オリゴデンドログリア / αシヌクレイン
Outline of Final Research Achievements

Multiple system atrophy (MSA) is a progressive neurodegenerative disorder. Clinical diagnosis of MSA could be challenging particularly in early stage, because of the phenotypic heterogeneity. In this study, we aimed to evaluate diagnostic value of CSF biomarkers and characterize its association with clinical parameters. We quantified CSF biomarkers including α-synuclein (α-syn), β-Amyloid42 (Aβ42), total tau (t-tau) and phosphorylated tau (p-tau) and NG2 in MSA patients. Clinical parameters including motor symptoms, nonmotor symptoms were assessed in association with CSF biomarkers. We found that CSF α-syn, Aβ42, and p-tau were significantly lower in MSA patients than in controls. We demonstrated that soluble NG2 is significantly elevated in CSF of MSA patients. The levels of CSF Aβ42 were significantly correlated with cognitive impairment in MSA. This study highlighted that CSF biomarkers may help distinguish MSA patients from control subjects.

Academic Significance and Societal Importance of the Research Achievements

多系統萎縮症の病態研究が進み,国内外で病態機序に即した疾患修飾薬の開発がすすめられている.疾患修飾薬の開発が進んだ場合,神経細胞の脱落が進んだ不可逆な状態では,薬剤の効果は限定的と考えられ,治療介入が可能な発症早期の診断が重要となってくる.多系統萎縮症は多様な臨床表現型を呈し,発症早期の診断は難しいケースが少なくないことから,早期診断に有用なバイオマーカーが求められている.また多系統萎縮症患者の症状進行速度は患者間で差が大きく,発症後の進行を予測するバイオマーカーも重要性が増している.本研究は多系統萎縮症の早期診断,進行予測に寄与しうると考えられる.

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2021 2020 2019 2018

All Presentation (8 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] 多系統萎縮症における脳脊髄液中NG2と臨床症状の検討2021

    • Author(s)
      徳武孝允
    • Organizer
      第62回日本神経学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 多系統萎縮症における認知機能障害と脳脊髄液バイオマーカーの検討2021

    • Author(s)
      徳武孝允
    • Organizer
      第40回日本認知症学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Analysis of CSF alpha-synuclein, amyloid-beta and tau in multiple system atrophy2020

    • Author(s)
      Takayoshi Tokutake, Kensaku Kasuga,Tamao Tsukie, Yo Higuchi, Takayoshi Shimohata,Osamu Onodera,Takeshi Ikeuchi
    • Organizer
      7th International Congress of Multiple System Atrophy
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 多系統萎縮症における脳脊髄液中NG2とα-シヌクレインの検討2020

    • Author(s)
      徳武孝允、春日健作、月江珠緒、樋口陽、下畑享良、小野寺理、池内健
    • Organizer
      第61回日本神経学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 多系統萎縮症における脳脊髄液中NG2と認知機能の検討2020

    • Author(s)
      徳武孝允、春日健作、月江珠緒、樋口陽、下畑享良、小野寺理、池内健
    • Organizer
      第39回日本認知症学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 多系統萎縮症における脳脊髄液バイオマーカーの検討2019

    • Author(s)
      徳武孝允
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 多系統萎縮症における脳脊髄液バイオマーカーと認知機能の検討2019

    • Author(s)
      徳武孝允
    • Organizer
      第38回日本認知症学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 多系統萎縮症における認知症関連・脳脊髄液バイオマーカーの検討2018

    • Author(s)
      徳武孝允
    • Organizer
      第37回認知症学会学術集会
    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi