Gender differences in autism spectrum disorders: clinical application for diagnosis

• Project/Area Number: 18K15481
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: University of Fukui
• Principal Investigator: Jung Minyoung 福井大学, 学術研究院医学系部門, 特命講師 (10774466)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 発達障害 / ADHD / 男女差 / ASD / 脳画像 / AI / fMRI

Outline of Final Research Achievements

Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized by atypical social communication and repetitive behaviors. In this study, we applied a multimodal approach to investigate brain structural connectivity, resting state activity, and surface area, as well as their associations with the core symptoms of ASD. We found that resting state brain activity and surface area in the lateral occipital cortex was negatively correlated with communication scores in boys with ASD. Our results suggest that decreased structural connectivity and resting-state brain activity in the occipital cortex may impair the integration of verbal and non-verbal communication cues in boys with ASD, thereby impacting their social development.

Academic Significance and Societal Importance of the Research Achievements

本研究で発見された自閉スペクトラム傾向のバイオマーカーを用いて複数の精神疾患や他の発達障害に応用することで、それぞれのバイオマーカーを探索することで、これまで症候だけに基づいていた障害の診断と分類を生物学的観点からも行うことができると考えられる。

Research Products

• [Int'l Joint Research] Harvard medical school(米国)
• [Int'l Joint Research] Daegu University(韓国)
• [Journal Article] Do Individuals With Autism Spectrum Disorders Help Other People With Autism Spectrum Disorders? An Investigation of Empathy and Helping Motivation in Adults With Autism Spectrum Disorder (2019)
  • Author(s): Komeda Hidetsugu、Kosaka Hirotaka、Fujioka Toru、Jung Minyoung、Okazawa Hidehiko
  • Journal Title: Frontiers in Psychiatry Volume: 10 Pages: 376-376
  • DOI: 10.3389/fpsyt.2019.00376
  • NAID: 120006777480
  • Peer Reviewed / Open Access
• [Journal Article] Structural brain abnormalities in children and adolescents with comorbid autism spectrum disorder and attention-deficit/hyperactivity disorder (2019)
  • Author(s): Mizuno Y, Kagitani-Shimono K, Jung M, Makita K, Takiguchi S, Fujisawa TX, Tachibana M, Nakanishi M, Mohri I, Taniike M, Tomoda A.
  • Journal Title: Transl Psychiatry. Volume: 9 Issue: 1 Pages: 332-332
  • DOI: 10.1038/s41398-019-0679-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identifying brain regions associated with the neuropathology of chronic low back pain: a resting-state amplitude of low-frequency fluctuation study (2019)
  • Author(s): Zhang Binlong、Jung Minyoung、Tu Yiheng、Gollub Randy、Lang Courtney、Ortiz Ana、Park Joel、Wilson Georgia、Gerber Jessica、Mawla Ishtiaq、Chan Suk-Tak、Wasan Ajay、Edwards Robert、Lee Jeungchan、Napadow Vitaly、Kaptchuk Ted、Rosen Bruce、Kong Jian
  • Journal Title: British Journal of Anaesthesia Volume: 123 Issue: 2 Pages: e303-e311
  • DOI: 10.1016/j.bja.2019.02.021
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Abnormal medial prefrontal cortex functional connectivity and its association with clinical symptoms in chronic low back pain (2019)
  • Author(s): Tu Yiheng、Jung Minyoung、Gollub Randy L.、Napadow Vitaly、Gerber Jessica、Ortiz Ana、Lang Courtney、Mawla Ishtiaq、Shen Wei、Chan Suk-Tak、Wasan Ajay D.、Edwards Robert R.、Kaptchuk Ted J.、Rosen Bruce、Kong Jian
  • Journal Title: PAIN Volume: 160 Issue: 6 Pages: 1308-1318
  • DOI: 10.1097/j.pain.0000000000001507
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of the Co‐occurrence of Anxiety and Attention‐Deficit/Hyperactivity Disorder on Intrinsic Functional Network Centrality among Children with Autism Spectrum Disorder (2019)
  • Author(s): Wan Bin、Wang Zengjian、Jung Minyoung、Lu Yanchun、He Haoqiang、Chen Qi、Jin Yu
  • Journal Title: Autism Research Volume: 12 Issue: 7 Pages: 1057-1068
  • DOI: 10.1002/aur.2120
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sex differences in white matter pathways related to language ability. (2019)
  • Author(s): Jung M, Mody M, Fujioka T, Kimura Y, Okazawa H, Kosaka H
  • Journal Title: Front Neurosci Volume: 13 Pages: 898-898
  • DOI: 10.3389/fnins.2019.00898
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Surface-based shared and distinct resting functional connectivity in attention-deficit hyperactivity disorder and autism spectrum disorder (2019)
  • Author(s): Jung, Minyoung Tu, Yiheng Park, Joel Jorgenson, Kristen Lang, Courtney Song, Wenwen Kong, Jian
  • Journal Title: The British Journal of Psychiatry Volume: 214 Issue: 06 Pages: 339-344
  • DOI: 10.1192/bjp.2018.248
  • Peer Reviewed
• [Journal Article] Decreased structural connectivity and resting-state brain activity in the lateral occipital cortex is associated with social communication deficits in boys with autism spectrum disorder (2019)
  • Author(s): Jung, Minyoung Tu, Yiheng Lang, Courtney Amanda Ortiz, Ana Park, Joel Jorgenson, Kristen Kong, Xue-Jun Kong, Jian
  • Journal Title: NeuroImage Volume: 190 Pages: 205-212
  • DOI: 10.1016/j.neuroimage.2017.09.031
  • Peer Reviewed
• [Journal Article] The effects of COMT polymorphism on cortical thickness and surface area abnormalities in children with ADHD (2018)
  • Author(s): Jung M, Mizuno Y (co-first author), Fujisawa TX, Takiguchi S, Kong J, Kosaka H, Tomoda A
  • Journal Title: Cerebral Cortex Volume: - Issue: 9 Pages: 3902-3911
  • DOI: 10.1093/cercor/bhy269
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 痛覚認知課題における痛覚の神経基盤 (2019)
  • Author(s): 丁 ミンヨン, 岡沢 秀彦, 小坂 浩隆
  • Organizer: 日本心理学会
• [Presentation] Structural connectivity and resting-state brain activity of the lateral occipital cortex impact social communication deficit in boys with autism spectrum disorder. (2019)
  • Author(s): Jung M, Fujioka T, Kosaka H
  • Organizer: The 7th World Congress of Asian Psychiatry 2019
  • Int'l Joint Research