| Project/Area Number |
18K15539
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 体幹部定位放射線治療 / 放射線誘発肺障害 / 放射線肺臓炎 / 放射線肺炎 / 放射線誘発性肺障害 / 定位放射線治療 / functional DVH解析 |
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| Outline of Final Research Achievements |
Radiation-induced lung toxicity after lung stereotactic radiotheapy (SRT) was prospectively analyzed using pre-SRT, 1-month, 4-month and 12-month fullow-up examinations including CT, laboratory data and pulmonary function tests. Sixteen patients were analyzed. Mean HU and SD of whole lung, KL-6 and SP-D peaked at 4 months after SRT, in contrast, all items of pulmonary function tests declined as time went on and they showed the lowest value at 12-month examination. SP-D at 4 months, forced vital capacity and diffusion capacity for carbon monoxide at 12 months showed significant relationships with lung dose-volume parameters. Furthermore, change of HU in each irradiated dose bins showed dose dependent HU change.
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| Academic Significance and Societal Importance of the Research Achievements |
SRTにおける肺線量と呼吸機能との関連を詳細に調べた報告は希少で、特に肺拡散能力とSRTの肺線量の相関の報告は知りうる限り初の報告となる。これによりSRT後のより詳細な呼吸機能予測の一助となることが期待される。
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