Feasibility study and clinical application for differential diagnosis using diffusion MRI with short diffusion time

• Project/Area Number: 18K15564
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Juntendo University
• Principal Investigator: Koshino Saori 順天堂大学, 医学部, 非常勤助手 (50801552)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 拡散時間 / 放射線学的病理学的相関 / 脳梗塞 / 脳腫瘍 / 拡散MRI / 拡散強調像

Outline of Final Research Achievements

Diffusion-weighted images, which visualize the diffusion motion of water molecules in tissue, are an essential MRI sequence for diagnostic imaging. Conventional diffusion-weighted images are useful for the diagnosis of benign and malignant tumors. OGSE technique uses a shorter diffusion time than conventional diffusion-weighted images and can distinguish whether diffusion limitation is due to the internal structure of the tumor or the viscosity within the tumor. We observed a wide variety of brain tumors using the OGSE method and investigated whether the OGSE method can help determine the malignancy of brain tumors when the malignancy is not known. Basic studies and observations of brain tumors were conducted and presented at domestic and international conferences and papers.

Academic Significance and Societal Importance of the Research Achievements

類上皮腫を観察しMagnetic Resonance in Medical Sciences誌(17(3):269-272, 2018)に掲載された。基礎的検討はJapanese Journal of Radiology誌(36(7):415-420, 2018)に掲載された。脈絡叢嚢胞の観察はMagnetic Resonance Imaging誌(57:323-327, 2019)に掲載した。良悪性の脳腫瘍を評価しMagnetic Resonance Imaging誌(72:34-41, 2020)に掲載された。OGSE法は良悪性の判断を助け、手術等の患者の侵襲を減らすことが期待される。

Research Products

• [Journal Article] Differentiation of high-grade and low-grade intra-axial brain tumors by time-dependent diffusion MRI (2020)
  • Author(s): Tomoko Maekawa, Masaaki Hori, Katsutoshi Murata, Thorsten Feiweier, Kouhei Kamiya, Christina Andica, Akifumi Hagiwara, Shohei Fujita, Saori Koshino, Toshiaki Akashi, Koji Kamagata, Akihiko Wada, Osamu Abe, Shigeki Aoki
  • Journal Title: Magnetic Resonance Imaging Volume: 72 Pages: 34-41
  • DOI: 10.1016/j.mri.2020.06.018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Choroid plexus cysts analyzed using diffusion-weighted imaging with short diffusion-time (2019)
  • Author(s): Tomoko Maekawa, Masaaki Hori, Katsutoshi Murata, Thorsten Feiweier, Christina Andica, Issei Fukunaga, Saori Koshino, Akifumi Hagiwara, Kouhei Kamiya, Koji Kamagata, Akihiko Wada, Osamu Abe, Shigeki Aoki
  • Journal Title: Magnetic Resonance Imaging Volume: 57 Pages: 323-327
  • DOI: 10.1016/j.mri.2018.12.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oscillating Gradient Spin Echo（OGSE）法を用いた拡散時間の短い拡散強調像による急性期脳梗塞の病態分析（大会長賞[最優秀賞]記録） (2018)
  • Author(s): 越野沙織、クリスティナ・アンディカ、堀正明、鈴木通真、萩原彰文、神谷昂平、前川朋子、入江隆介、福永一星、村田渉、堀田萌子、武中祐樹、青木茂樹
  • Journal Title: 日本磁気共鳴医学会雑誌 Volume: 38 Pages: 11-14
  • Peer Reviewed / Open Access
• [Journal Article] Oscillating gradient spin echo（OGSE）法による拡散強調像の基礎的検討：基質の粘稠度の違いによるADC値の変化（大会長賞記録） (2018)
  • Author(s): 前川朋子、福永一星、堀正明、村田勝俊、越野沙織、クリスティナ・アンディカ、入江隆介、萩原彰文、村田渉、濵﨑望、堀田萌子、武中祐樹、青木茂樹
  • Journal Title: 日本磁気共鳴医学会雑誌 Volume: 38 Pages: 6-10
  • Peer Reviewed / Open Access
• [Journal Article] Spatial Restriction within Intracranial Epidermoid Cysts Observed Using Short Diffusion-time Diffusion-weighted Imaging (2018)
  • Author(s): Christina Andica, Masaaki Hori, Kouhei Kamiya, Saori Koshino, Akifumi Hagiwara, Koji Kamagata, Issei Fukunaga, Nozomi Hamasaki, Michimasa Suzuki, Thorsten Feiweier, Katsutoshi Murata, Atsushi Arakawa, Akihide Kondo, Osamu Akiyama, Shigeki Aoki
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 17 Issue: 3 Pages: 269-272
  • DOI: 10.2463/mrms.cr.2017-0111
  • NAID: 130007403806
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Changes in the ADC of diffusion-weighted MRI with the oscillating gradient spin-echo (OGSE) sequence due to differences in substrate viscosities (2018)
  • Author(s): Tomoko Maekawa, Masaaki Hori, Katsutoshi Murata, Thorsten Feiweier, Issei Fukunaga, Christina Andica, Akifumi Hagiwara, Koji Kamagata, Saori Koshino, Osamu Abe, Shigeki Aoki
  • Journal Title: Japanese Journal of Radiology Volume: 36 Issue: 7 Pages: 415-420
  • DOI: 10.1007/s11604-018-0737-0
  • NAID: 50012896039
  • Peer Reviewed / Open Access
• [Presentation] OGSE diffusion weighted imaging of epidermoid cysts: 3D Monte Carlo simulation (2019)
  • Author(s): Saori Koshino, Akiyuki Sakakibara, Christina Andica, Akifumi Hagiwara, Masaaki Hori, Osamu Abe, Shigeki Aoki
  • Organizer: 27th Annual Meeting of the International Society for Magnetic Resonance in Medicine (Educational Stipend Award受賞)
  • Int'l Joint Research
• [Presentation] OGSEでの拡散時間計測における脳脊髄液の流れの影響 (2019)
  • Author(s): 白戸貴志、後藤政実、堀正明、越野沙織、前川朋子、福永一星、青木茂樹、五味勉
  • Organizer: 第42回 日本脳神経CI学会総会
• [Presentation] Oscillating Gradient Spin Echo (OGSE) Diffusion Weighted Imaging of the Acute Cerebral Infarction (2018)
  • Author(s): Saori Koshino, Christina Andica, Masaaki Hori, Michimasa Suzuki, Akifumi Hagiwara, Kouhei Kamiya, Tomoko Maekawa, Ryusuke Irie, Issei Fukunaga, Syo Murata, Moeko Horita, Yuki Takenaka, Mihiro Takemori, Shigeki Aoki
  • Organizer: 6th International Congress on Magnetic Resonance Imaging
  • Int'l Joint Research / Invited
• [Presentation] Diffusion-weighted MRI with Oscillating Gradient Spin Echo (OGSE) sequence: Changes of ADC due to differences in the viscosity of substrates (2018)
  • Author(s): Tomoko Maekawa, Issei Fukunaga, Masaaki Hori, Katsutoshi Murata, Saori Koshino, Christina Andica, Ryusuke Irie, Akifumi Hagiwara, Sho Murata, Nozomi Hamasaki, Moeko Horita, Yuki Takenaka, Shigeki Aoki
  • Organizer: 6th International Congress on Magnetic Resonance Imaging
  • Int'l Joint Research / Invited
• [Presentation] Oscillating gradient spin echo (OGSE) diffusion weighted imaging of the epidermoid cysts: simulation application (2018)
  • Author(s): Saori Koshino, Akiyuki Sakakibara, Antoine Choppin, Christina Andica, Akifumi Hagiwara, Tomoko Maekawa, Mihiro Takemori, Atsushi Arakawa, Lydia Chougar, Masaaki Hori, Shigeki Aoki
  • Organizer: 26th Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Int'l Joint Research
• [Presentation] Diffusion Time Dependence of NODDI in in vivo Human White Matter (2018)
  • Author(s): Masaaki Hori, Kouhei Kamiya, Katsutoshi Murata, Thorsten Feiweier, Issei Fukunaga, Akifumi Hagiwara, Ryusuke Irie, Christina Andica, Tomoko Maekawa, Saori Koshino, Koji Kamagata, Kanako Kunishima Kumamaru, Michimasa Suzuki, Akihiko Wada, Shigeki Aoki
  • Organizer: 26th Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Int'l Joint Research
• [Presentation] OGSEの現状と今後の展望 (2018)
  • Author(s): 越野沙織
  • Organizer: 第46回 日本磁気共鳴医学会大会
  • Invited
• [Presentation] 短い拡散時間により急性期脳梗塞の信号が低下した3例：OGSEによる拡散テンソル解析 (2018)
  • Author(s): 白戸貴志、後藤政実、越野沙織、アラニット・ブーンロッド、萩原彰文、堀正明、福永一星、クリスティナ・アンディカ、前川朋子、青木茂樹、五味勉
  • Organizer: 第46回 日本磁気共鳴医学会大会
• [Presentation] 類上皮腫における拡散テンソル変数の拡散時間依存性 (2018)
  • Author(s): クリスティナ・アンディカ、堀正明、前川朋子、白戸貴志、福永一星、越野沙織、萩原彰文、和田昭彦、鎌形康司、青木茂樹
  • Organizer: 第46回 日本磁気共鳴医学会大会
• [Presentation] Oscillating Gradient Spin Echo法による拡散時間の影響：アスパラガスファントムを用いた検討 (2018)
  • Author(s): 福永一星、堀正明、村田勝俊、前川朋子、濵﨑望、神谷昂平、越野沙織、鶴田航平、村田渉、高野直、川﨑英生、佐藤秀二、芳士戸治義、鈴木通真、青木茂樹
  • Organizer: 第46回 日本磁気共鳴医学会大会
• [Presentation] 脳腫瘍におけるOscillating gradient spin echo (OGSE)法を用いた拡散時間依存性の検討：Atypical teratoid/rhabdoid tumorでの経験 (2018)
  • Author(s): 前川朋子、堀正明、Christina Andica、萩原彰文、堀田萌子、春山拓也、越野沙織、池之内穣、入江隆介、神谷昂平、村田勝俊、和田昭彦、青木茂樹
  • Organizer: 第13回 小児神経放射線研究会
• [Presentation] Apparent diffusion coefficient of cerebrospinal fluid is influenced by diffusion time (2018)
  • Author(s): Takashi Shirato, Masami Goto, Saori Koshino, Masaaki Hori, Shigeki Aoki, Tsutomu Gomi
  • Organizer: 9th Taiwan Association of Medical Radiation Technologists International Forum
  • Int'l Joint Research
• [Presentation] Radiologic-Pathologic Correlation for Differential Diagnosis Using Diffusion MRI with a Short Diffusion Time (2018)
  • Author(s): Saori Koshino, Mihiro Takemori, Christina Andica, Masaaki Hori, Koji Kamagata, Kanako Kumamaru, Akihiko Wada, Takeyuki Watadani, Harushi Mori, Osamu Abe, Shigeki Aoki
  • Organizer: 104th Annual Meeting of Radiological Society of North America
  • Int'l Joint Research
• [Book] Rad Fan 2019年2月号 (2019)
  • Author(s): 越野沙織
  • Total Pages: 104
  • Publisher: メディカルアイ
  • ISBN: 4862911889
• [Book] 画像診断 2018年増刊号 頭部の鑑別診断のポイント (2018)
  • Author(s): 越野沙織
  • Total Pages: 244
  • Publisher: 学研メディカル秀潤社
  • ISBN: 4780909589
• [Remarks] researchmap
  • URL: https://researchmap.jp/saori.koshino/
• [Remarks] ResearchGate
  • URL: https://www.researchgate.net/profile/Saori_Koshino