Establishment of a New Diffusion-Weighted MRI Imaging Method Directly Related to Personalized Breast Cancer Treatment

• Project/Area Number: 18K15588
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kyoto University
• Principal Investigator: Iima Mami 京都大学, 医学研究科, 助教 (60748797)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: MRI / 拡散 / 非ガウス拡散 / 乳腺腫瘍 / 乳癌 / 拡散強調MRI / 診断 / IVIM / 非ガウス拡散MRI

Outline of Final Research Achievements

We investigated the effects of different acquisition parameters such as diffusion time and TE on the quantitative values of diffusion-weighted MRI in several types of xenograft models. We found a significant correlation between the rate of change in apparent diffusion coefficient (ADC) with diffusion time and histological biomarkers such as Ki-67 in breast cancer, reflecting cell proliferation. In clinical cases, we investigated the effect of different diffusion times on ADC values. In clinical cases, the effects of different diffusion times and other factors on the quantitative values of diffusion-weighted MRI were investigated, focusing mainly on the effects on the ADC and ADC change, and their diagnostic usefulness in differentiating between benign and malignant breast tumors and the presence or absence of hormone receptor expression in malignant tumors was presented at the international meetings, and a paper was published.

Academic Significance and Societal Importance of the Research Achievements

今まで主に定性的評価に留まっていた腫瘍内部の新たな定量評価が可能となり、乳癌のホルモン受容体発現の有無との関連も見いだされた。特に造影剤アレルギーなど、造影剤の使用困難な症例において、拡散強調像を用いた新たな診断法が有用となる可能性がある。

Research Products

• [Journal Article] The Rate of Apparent Diffusion Coefficient Change With Diffusion Time on Breast Diffusion-Weighted Imaging Depends on Breast Tumor Types and Molecular Prognostic Biomarker Expression (2021)
  • Author(s): Iima Mami、Kataoka Masako、Honda Maya、Ohashi Akane、Ohno Kishimoto Ayami、Ota Rie、Uozumi Ryuji、Urushibata Yuta、Feiweier Thorsten、Toi Masakazu、Nakamoto Yuji
  • Journal Title: Investigative Radiology Volume: Publish Ahead of Print Issue: 8 Pages: 00-00
  • DOI: 10.1097/rli.0000000000000766
  • Peer Reviewed
• [Journal Article] Diffusion MRI of the breast: Current status and future directions (2019)
  • Author(s): Iima M, Honda M, Sigmund EE, Ohno Kishimoto A, Kataoka M, Togashi K
  • Journal Title: Journa of Magnetic Resonance Imagng Volume: - Issue: 1 Pages: 70-90
  • DOI: 10.1002/jmri.26908
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Time-dependent diffusion MRI to distinguish malignant from benign head and neck tumors (2018)
  • Author(s): Iima Mami、Yamamoto Akira、Kataoka Masako、Yamada Yosuke、Omori Koichi、Feiweier Thorsten、Togashi Kaori
  • Journal Title: Journal of Magnetic Resonance Imaging Volume: ‐ Issue: 1 Pages: 88-95
  • DOI: 10.1002/jmri.26578
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Investigation of new cancer diagnosis using non-Gaussian diffusion MRI and IVIM (2018)
  • Author(s): Iima Mami
  • Journal Title: Impact Volume: 2018 Issue: 12 Pages: 41-43
  • DOI: 10.21820/23987073.2018.12.41
  • Int'l Joint Research
• [Presentation] Clinical Diffusion Time Dependency of Breast Tumors and Associations with Prognostic Factors. (2020)
  • Author(s): Iima M, Kataoka M, Honda M, Kishimoto AO, Ota R, Ohashi A, Y.Urushibata Y, Feiweier T Toi M, Togashi K.
  • Organizer: ISMRM & SMRT Virtual Conference & Exhibition
  • Int'l Joint Research
• [Presentation] Investigation of breast cancer microstructure and microvasculature from time-dependent DWI and CEST in correlation with histology. (2020)
  • Author(s): Someya Y, Iima M, Imai H, Yoshizawa A, Nakamoto Y, Kataoka M, Isoda H. Togashi K.
  • Organizer: ISMRM & SMRT Virtual Conference & Exhibition
  • Int'l Joint Research
• [Presentation] DWI of the Breast (2020)
  • Author(s): Iima M
  • Organizer: ISMRM & SMRT Virtual Conference & Exhibition
  • Int'l Joint Research / Invited
• [Presentation] Noninvasive Quantification of Breast Cancer Microstructure Using CEST and Diffusion MRI (2020)
  • Author(s): Yuko Someya, Mami Iima, Hirohiko Imai, Akihiko Yoshizawa, Hiroyoshi Isoda, Kaori Togashi
  • Organizer: 第79回日本医学放射線学会
• [Presentation] Apparent diffusion distance as a means of revealing breast tumor micro-structure in vivo (2020)
  • Author(s): 飯間 麻美、 片岡 正子, 本田 茉也, 大野 文美, 太田 理恵, 大橋 茜, 三宅 可奈江, 戸井 雅和, 富樫 かおり
  • Organizer: 第28回日本乳癌学会学術総会
• [Presentation] Feasibility of time-dependent ADC values of breast cancer in the clinics (2020)
  • Author(s): Mami Iima，Masako Kataoka，Maya Honda，Ayami Ohno Kishimoto，Rie Ota，Akane Ohashi，Yuta Urushibata，Masakazu Toi, Yuji Nakamoto
  • Organizer: 第48回日本磁気共鳴医学会大会
• [Presentation] Time-dependent ADC values in association with histological biomarkers in breast cancer xenograft models (2020)
  • Author(s): Yuko Someya，Mami Iima，Hirohiko Imai，Akihiko Yoshizawa，Hiroyoshi Isoda，Masako Kataoka，Yuji Nakamoto
  • Organizer: 第48回日本磁気共鳴医学会大会
• [Presentation] 乳腺の拡散強調画像: ADCとその先に (2020)
  • Author(s): 飯間 麻美
  • Organizer: 第48回日本磁気共鳴医学会大会
  • Invited
• [Presentation] Time Dependent IVIM and non-Gaussian DW parameters in Breast Xenograft models (2020)
  • Author(s): Yuko Someya , Mami Iima, Hirohiko Imai, Hiroyoshi Isoda, Masako Kataoka, Denis Le Bihan, Yuji Nakamoto
  • Organizer: The 5th ISMRM-Japanese Chapter Annual Scientific Meeting
• [Presentation] Time-Varying Diffusion Patterns in Breast Cancer Linked to Prognostic Factors (2019)
  • Author(s): Mami Iima , Masako Kataoka , Maya Honda , Ayami Kishimoto Ohno , Rie Ota , Akane Ohashi , Yuta Urushibata , Thorsten Feiweier , Masakazu Toi , and Kaori Togashi
  • Organizer: ISMRM 27th Annual Meeting & Exhibition, Montreal, Canada
  • Int'l Joint Research
• [Presentation] 乳腺腫瘍良悪性鑑別における異なる拡散時間を用いたADC値の有用性 (2019)
  • Author(s): 飯間麻美, 片岡正子, 本田茉也, 大野文美, 太田理恵, 大橋茜, 三宅可奈江, 戸井雅和, 富樫かおり
  • Organizer: 第27回日本乳癌学会学術総会
• [Presentation] 時間依存拡散MRIは乳癌の微細構造への臨床的アプローチを可能とする (2019)
  • Author(s): 羽賀すみれ、飯間麻美、片岡正子、本田茉也、大野文美、太田理恵、大橋茜、三宅可奈江、漆畑勇太、Thorsten Feiweier、戸井雅和、富樫かおり
  • Organizer: 第47回 磁気共鳴医学会学術総会
• [Presentation] Power of Time-dependent Diffusion MRI as a Prognostic Biomarker in the Breast (2019)
  • Author(s): Power of Time-dependent Diffusion MRI as a Prognostic Biomarker in the Breast
  • Organizer: Radiological Society of North America
  • Int'l Joint Research
• [Presentation] Time-dependent diffusion MRI to distinguish malignant from benign head and neck tumours. (2019)
  • Author(s): S. Kawakami, M. Iima, A. Yamamoto, M. Kataoka, Y. Yamada, K. Omori, T. Feiweier, K. Togashi.
  • Organizer: European Congress of Radiology (ECR), Vienna, Austria.
  • Int'l Joint Research
• [Presentation] IVIM and non-Gaussian diffusion MRI of the breast. (2019)
  • Author(s): Mami Iima
  • Organizer: International Congress on Magnetic Resonance Imaging （ICMRI）, Seoul, Korea.
  • Int'l Joint Research / Invited
• [Presentation] Diffusion Time Dependence of ADC Values for the Differentiation of Malignant & Benign Breast Tumors (2018)
  • Author(s): Mami Iima, Masako Kataoka, Maya Honda, Akane Ohashi, Ayami Ohno Kishimoto, Rie Ota, Kanae Miyake Kawai, Katsutoshi Murata, Thorsten Feiweier, Masakazu.Toi, and Kaori Togashi
  • Organizer: ISMRM Workshop on Breast MRI. Las Vegas, NV, USA
  • Int'l Joint Research
• [Presentation] 乳癌のIVIM/非ガウス拡散MRIイメージング (2018)
  • Author(s): 飯間麻美
  • Organizer: 磁気共鳴医学会大会
  • Invited
• [Presentation] 水分子の拡散を通じてがんの特徴を捉える～新たな拡散強調MRI腫瘍診断法の開発～ (2018)
  • Author(s): 飯間麻美
  • Organizer: バイオインダストリー協会 "未来へのバイオ技術" 勉強会「京大発：非侵襲、低侵襲で新薬開発・診断・計測に貢献する３つのツール」
  • Invited
• [Presentation] 拡散時間：非ガウス拡散とIVIM MRIを用いた新たな癌診断法の開発 (2018)
  • Author(s): 飯間麻美
  • Organizer: 第2回創薬医学シンポジウム 「オープンイノベーションから創薬へ」 京都大学
  • Invited
• [Presentation] Comparison of ADC values obtainedwith OGSE and PGSE sequences for differentiation of human benign breast tumors (2018)
  • Author(s): M.Iima, M.Kataoka, M.Honda, A. O. Kishimoto, K. K. Miyake, Y.Urushibata, T.Feiweier, M.Toi, and K.Togashi
  • Organizer: 磁気共鳴医学会大会
• [Presentation] Comparison of ADC values obtainedwith OGSE and PGSE sequences for differentiation of human head and neck lymphoma and squamous cell carcinoma (2018)
  • Author(s): M.Iima, A.Yamamoto, I.Tateya, M.Kitamura, T.Feiweier, K.Omori, and K.Togashi
  • Organizer: 磁気共鳴医学会大会
• [Presentation] Investigation of IVIM and non-Gaussian diffusion MR parameters in benign breast tumors. (2018)
  • Author(s): K.Kobashi, M.Iima, M.Kataoka, S.Kanao, M.Honda, A.Ohno, R.Ota, A.Ohashi, K.Miyake, M.Toi, K.Togashi
  • Organizer: 磁気共鳴医学会大会
• [Presentation] 非ガウス拡散MRIを用いた浸潤性乳管癌と非浸潤性乳管癌の鑑別の有用性の検討 (2018)
  • Author(s): 鈴木 瑞恵、飯間 麻美、片岡 正子、三宅 可奈江、阪口 怜奈、 大野 文美、本田 茉也、戸井 雅和、富樫 かおり
  • Organizer: 第25回日本乳癌学会学術総会
• [Book] Intravoxel Incoherent Motion (IVIM) MRI: Principles and Applications 1st Edition (2018)
  • Author(s): Denis Le Bihan, Mami Iima, Christian Federau, Eric E. Sigmund
  • Total Pages: 562
  • Publisher: Pan Stanford
  • ISBN: 9789814800198