The radiation dose escalation study for limited-disease small-cell lung cancer
Project/Area Number |
18K15616
|
Research Category |
Grant-in-Aid for Early-Career Scientists
|
Allocation Type | Multi-year Fund |
Review Section |
Basic Section 52040:Radiological sciences-related
|
Research Institution | Osaka International Cancer Institute |
Principal Investigator |
Masahiro Morimoto 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 放射線腫瘍科副部長 (00745359)
|
Project Period (FY) |
2018-04-01 – 2022-03-31
|
Project Status |
Completed (Fiscal Year 2021)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2020: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2019: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | 放射線治療 / 息止め照射 / 限局型小細胞肺癌 |
Outline of Final Research Achievements |
Three lung tumor cases are entered in this study. The aim of this study is a comparison of inspiratory breath holding system signal and real-time position management system signal at the radiation planning computed tomography. The three cases of the inspiratory breath holding system signal and real-time position management system signal ±standard deviation(%) are ±4, ±3, ±1 and ±13, ±6, ±7, respectively. The three cases planning target volume of the virtual radiation planning at inspiratory breath holding system are 1.5 cc lower than those of the actual radiation planning of real-time position management system. Then, lung V20 and V5 are 1.2% and 2.7% lower in virtual radiation planning at inspiratory breath holding system than those of actual radiation planning of real-time position management system. The signal of inspiratory breath holding system is more stable than that of real-time position management system.
|
Academic Significance and Societal Importance of the Research Achievements |
学術的意義は、肺腫瘍の放射線治療に関して、吸気実測息止めシステムの信号波形が、従来の腹壁に置いた赤外線マーカーの信号波形に比べて安定していて、治療計画CTに使用可能である。照射体積を減らし、正常組織に当たる放射線の量を減らせる。社会的意義は、臨床応用ができれば、患者の放射線治療による有害事象を減らすことができる。照射体積を減らすことによって、腫瘍内を、今までより正確に線量増加できる可能性がでてくる。
|
Report
(5 results)
Research Products
(13 results)
-
[Journal Article] Prolonged overall treatment time negatively affects the outcomes of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: A propensity score-weighted, single-center analysis.2021
Author(s)
Ikawa T, Tabuchi T, Konishi K, Morimoto M, Hirata T, Kanayama N, Wada K, Toratani M, Okawa S, Ogawa K, Teshima T.
-
Journal Title
PLoS One.
Volume: 16
Issue: 6
Pages: e0253203-e0253203
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Intensity-modulated radiation therapy with concurrent chemotherapy followed by durvalumab for stage III non-small cell lung cancer: A multi-center retrospective study.2021
Author(s)
Tsukita Y, Yamamoto T, Mayahara H, Hata A, Takeda Y, Nakayama H, Tanaka S, Uchida J, Usui K, Toyoda T, Tamiya M, Morimoto M, Oya Y, Kodaira T, Miyauchi E, Jingu K, Sugiura H.
-
Journal Title
Radiother Oncol.
Volume: 160
Pages: 266-272
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Elective nodal irradiation for non-small cell lung cancer complicated with chronic obstructive pulmonary disease affects immunotheray after definitive chemoradiotherapy.2020
Author(s)
M Morimoto, K Nishino, K Wada, F Imamura, K Konishi, H Kuhara, M Tamiya, T Inoue, K Kunimasa, M Kimura, T Hirata, N Kanayama, M Toratani, H Kawachi, K Ohira, E Nakanishi, S Ohira, T Sagawa, M Miyazaki, T Matsunaga, T Kumagai, T Teshima.
-
Journal Title
Anticancer Research
Volume: 40
Issue: 12
Pages: 6957-6970
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Predictors of Acute Radiation Esophagitis in Non-small Cell Lung Cancer Patients Treated With Accelerated Hyperfractionated Chemoradiotherapy.2019
Author(s)
Wada K, Kishi N, Kanayama N, Hirata T, Ueda Y, Kawaguchi Y, Morimoto M, Konishi K, Imamura F, Ogawa K, Teshima T.
-
Journal Title
Anticancer research
Volume: 39
Issue: 1
Pages: 491-497
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Presentation] EGFR-TKIは初診時に重症SREs( skeletal-related events)をきたした肺癌患者の予後を改善させうる2018
Author(s)
Kei Kunimasa, Yasuyuki Arai, Kazuya Oshima, Yoshinori Imura, Masahiro Morimoto, Kentaro Wada, Madoka Kimura, Takako Inoue, Motohiro Tamiya, Kazumi Nishino, Toru Kumagai, Norifumi Naka, Teruki Teshima, Fumio Imamura
Organizer
第16回日本臨床腫瘍学会学術集会
Related Report
-
-