• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a methodology for predicting radiation therapy prognosis based on a radiomics with variability of patients in the treatment

Research Project

Project/Area Number 18K15625
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionHokkaido University (2020-2021)
The University of Tokyo (2018-2019)

Principal Investigator

Nakamoto Takahiro  北海道大学, 保健科学研究院, 助教 (10808877)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsRadiomics / 予後予測 / 放射線治療 / 患者変動 / 医学物理学 / 食道扁平上皮がん / CBCT画像 / コックス回帰 / リスクスコア / ログランク検定 / DIR / 神経膠腫 / 肺がん転移性脳腫瘍 / 機械学習 / 予後因子予測
Outline of Final Research Achievements

The purpose of the study was to develop a system for predicting radiation therapy prognosis based on a radiomics with patient’s variability in the treatment. Radiomic features with patient’s variability were extracted from multi-modal medical images acquired in and before the radiation therapy. We developed system for predicting radiation therapy prognosis and factors related to the prognosis using the radiomic features with patient’s variability. We have been suggested that the radiomics-based system with the patient’s variability would be feasible for predicting the radiation therapy prognosis.

Academic Significance and Societal Importance of the Research Achievements

本研究において治療時の患者変動を含んだRadiomics特徴量と放射線治療予後との関係を学習させてモデリングすることにより治療時患者変動を考慮した上で予後が予測できる可能性を示した.また,本研究で開発したシステムを用いて予測した予後の結果を治療計画時や治療中にフィードバックすることで患者個々の変動や特徴に最適化されたオーダーメイド放射線治療の実現が期待できる.必要なデータは放射線治療を行なう上で取得される医用画像と予後情報のみであるため,提案したシステムで構築したモデルを用いれば他施設でも簡便に予後を予測することが可能で臨床的な意義が高い.

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (29 results)

All 2022 2021 2020 2019 2018 Other

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 7 results) Presentation (18 results) (of which Int'l Joint Research: 9 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Training of deep cross‐modality conversion models with a small dataset, and their application in megavoltage CT to kilovoltage CT conversion2022

    • Author(s)
      Ozaki S, Kaji S, Nawa K, Imae T, Aoki A, Nakamoto T, Ohta T, Nozawa Y, Yamashita H, Haga A, Nakagawa K
    • Journal Title

      Medical Physics

      Volume: - Issue: 6 Pages: 1-14

    • DOI

      10.1002/mp.15626

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improvement in Image Quality of CBCT during Treatment by Cycle Generative Adversarial Network2020

    • Author(s)
      今江 禄一, 鍛冶 静雄, 木田 智士, 松田 佳奈子, 竹中 重治, 青木 淳, 仲本 宗泰, 尾崎 翔, 名和 要武, 山下 英臣, 中川 恵一, 阿部 修.
    • Journal Title

      Japanese Journal of Radiological Technology

      Volume: 76 Issue: 11 Pages: 1173-1184

    • DOI

      10.6009/jjrt.2020_JSRT_76.11.1173

    • NAID

      130007941322

    • ISSN
      0369-4305, 1881-4883
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visual enhancement of Cone‐beam CT by use of CycleGAN2020

    • Author(s)
      Kida S, Kaji S, Nawa K, Imae T, Nakamoto T, Ozaki S, Ohta T, Nozawa Y, Nakagawa K.
    • Journal Title

      Medical Physics

      Volume: 47(3) Issue: 3 Pages: 998-1010

    • DOI

      10.1002/mp.13963

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fast Statistical Iterative Reconstruction for Mega-voltage Computed Tomography2020

    • Author(s)
      S. Ozaki, A. Haga, E. Chao, C. Maurer, K. Nawa, T. Ohta, T. Nakamoto, Y. Nozawa, T. Magome, M. Nakano, K. Nakagawa
    • Journal Title

      The Journal of Medical Investigation

      Volume: 67 Issue: 1.2 Pages: 30-39

    • DOI

      10.2152/jmi.67.30

    • NAID

      130007839921

    • ISSN
      1343-1420, 1349-6867
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prediction of malignant glioma grades using contrast-enhanced T1-weighted and T2-weighted magnetic resonance images based on a radiomic analysis2019

    • Author(s)
      Nakamoto Takahiro、Takahashi Wataru、Haga Akihiro、Takahashi Satoshi、Kiryu Shigeru、Nawa Kanabu、Ohta Takeshi、Ozaki Sho、Nozawa Yuki、Tanaka Shota、Mukasa Akitake、Nakagawa Keiichi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 19411-19423

    • DOI

      10.1038/s41598-019-55922-0

    • NAID

      120006875662

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Radiomics analysis for glioma malignancy evaluation using diffusion kurtosis and tensor imaging2019

    • Author(s)
      Takahashi S, Takahashi W, Tanaka S, Haga A, Nakamoto T, Suzuki Y, Mukasa A, Takayanagi S, Kitagawa Y, Hana T, Nejo T, Nomura M, Nakagawa K, Saito N
    • Journal Title

      International Journal of Radiation Oncology Biology Physics

      Volume: 105 Issue: 4 Pages: 784-791

    • DOI

      10.1016/j.ijrobp.2019.07.011

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] An Introduction to Radiomics: Toward a New Era of Precision Medicine2018

    • Author(s)
      仲本 宗泰, 芳賀 昭弘, 高橋 渉
    • Journal Title

      Japanese Journal of Medical Physics (Igakubutsuri)

      Volume: 38 Issue: 3 Pages: 129-134

    • DOI

      10.11323/jjmp.38.3_129

    • NAID

      130007550535

    • ISSN
      1345-5354, 2186-9634
    • Year and Date
      2018-12-25
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cone Beam Computed Tomography Image Quality Improvement Using a Deep Convolutional Neural Network2018

    • Author(s)
      Kida Satoshi、Nakamoto Takahiro、Nakano Masahiro、Nawa Kanabu、Haga Akihiro、Kotoku Jun'ichi、Yamashita Hideomi、Nakagawa Keiichi
    • Journal Title

      Cureus

      Volume: - Pages: 1-15

    • DOI

      10.7759/cureus.2548

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Volumetric and dosimetric comparison of organs at risk between the prone and supine positions in postoperative radiotherapy for prostate cancer2018

    • Author(s)
      Sawayanagi S, Yamashita H, Ogita M, Kiritoshi T, Nakamoto T, Abe O, Nakagawa K
    • Journal Title

      Radiation Oncology

      Volume: 13 Issue: 1

    • DOI

      10.1186/s13014-018-1023-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Training modality conversion models with small data and its application to MVCT to kVCT conversion2021

    • Author(s)
      Ozaki S, Kaji S, Nawa K, Imae T, Aoki A, Nakamoto T, Ohta T, Nozawa Y, Haga A, Nakagawa K
    • Organizer
      ESTRO 2021 Annual Meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Imaging biomarker analysis for grading malignant gliomas based on a few conventional magnetic resonance imaging sequences2020

    • Author(s)
      Nakamoto T, Takahashi W, Haga A, Takahashi S, Kiryu S, Nawa K, Ohta T, Ozaki S, Nozawa Y, Tanaka S, Mukasa A, Nakagawa K
    • Organizer
      2020 Joint AAPM COMP Meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Radiomic-based prediction of malignant glioma grades using preoperative contrast-enhanced T1WIs and T2WIs2020

    • Author(s)
      Nakamoto T, Takahashi W, Haga A, Takahashi S, Kiryu S, Nawa K, Ohta T, Ozaki S, Nozawa Y, Nakagawa K.
    • Organizer
      第119回日本医学物理学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Prediction of uterus volume shrinkage for cervical cancer patients during radiotherapy using machine-learning approach with treatment planning-CT radiomic features2020

    • Author(s)
      Nakano M, Nakamoto T, Kumai Y, Koizumi Y, Sumi M, Nawa K, Imae T, Yoshioka Y, Oguchi M
    • Organizer
      2020 Joint AAPM COMP Meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 左乳癌乳房全切除術後照射における3D-CRTとVMATの比較および呼吸性移動の検討2020

    • Author(s)
      野沢勇樹, 扇田真美, 名和要武, 太田岳史, 尾崎翔, 仲本宗泰, 山下英臣, 中川恵一
    • Organizer
      第33回日本放射線腫瘍学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Prediction of EGFR mutation status in lung adenocarcinomas through brain metastases using an MRI-based radiomics2019

    • Author(s)
      Nakamoto T, Takahashi W, Amano Y, Nawa K, Ohta T, Ozaki S, Nozawa Y, Yamashita H, Nakagawa K
    • Organizer
      19th Asia-Oceania Congress of Medical Physics
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Trial of dose distribution QA using smartphone and tablet camera with scintillator2019

    • Author(s)
      Ohta T, Nawa K, Ozaki S, Nozawa Y, Nakamoto T, Nakagawa K
    • Organizer
      19th Asia-Oceania Congress of Medical Physics
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Visualization of judgment basis of CNN to grading glioma2019

    • Author(s)
      Takahashi S, Tanaka S, Takahashi M, Yamazawa E, Hana T, Kitagawa Y, Takayanagi S, Takahashi W, Nakamoto T, Haga S, Hamamoto R, Saito N
    • Organizer
      24th Annual meeting of Society for NeuroOncology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] A novel radiomics model differentiating chordoma and chondrosarcoma2019

    • Author(s)
      Yamazawa E, Takahashi S, Tanaka S, Takahashi W, Nakamoto T, Takayanagi S, Kitagawa Y, Hana T, Koike T, Kushihara Y, Shin Masahiro, Saito N
    • Organizer
      24th Annual meeting of Society for NeuroOncology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pseudo-CBCT image prediction of head and neck cancer patient using principal component vector fields of early treatment fractions2019

    • Author(s)
      Nakano M, Imae T, Nakamoto T, Nawa K, Haga A, Takahashi W, Nakagawa K, Hashimoto M, Yoshioka Y, Oguchi M
    • Organizer
      第117回医学物理学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 左乳癌乳房全切除術後照射におけるVMATと3D-CRTの治療計画の比較2019

    • Author(s)
      野沢勇樹, 扇田真美, 名和要武, 太田岳史, 尾崎翔, 仲本宗泰, 山下英臣, 中川恵一
    • Organizer
      第32回日本放射線腫瘍学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Radiomics-based prediction of malignant glioma grades using T2-weighted magnetic resonance images2018

    • Author(s)
      Nakamoto T, Takahashi W, Haga A, Takahashi S, Nawa K, Ohta T, Ozaki S, Tanaka S, Mukasa A, Nakagawa K
    • Organizer
      The American Association of Physicists in Medicine 60th Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Radiomics analysis for detection of IDH mutation of glioma using diffusion tensor and kurtosis images2018

    • Author(s)
      Takahashi S, Takahashi W, Tanaka S, Haga A, Nakamoto T, Mukasa A, Takayanagi S, Suzuki Y, Koike T, Kitagawa Y, Hana T, Nejo T, Nomura M, Saito N
    • Organizer
      Society for Neuro-Oncology 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] A feasibility study for classifying malignant glioma grades based on a radiomics analysis2018

    • Author(s)
      Nakamoto T, Takahashi W, Haga A, Takahashi S, Nawa K, Ohta T, Ozaki S, Nozawa Y, Tanaka S, Mukasa A, Nakagawa K
    • Organizer
      日本放射線腫瘍学会第31回学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] MRI画像に基づくラディオミクスによる神経膠腫1p/19q共欠失の非侵襲的解析2018

    • Author(s)
      高橋渉, 仲本宗泰, 芳賀昭弘, 高橋慧, 田中将太, 山下英臣, 中川恵一
    • Organizer
      日本放射線腫瘍学会第31回学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 拡散画像のRadiomics解析と機械学習モデルによるIDH-1遺伝子変異の同定2018

    • Author(s)
      高橋慧, 高橋渉, 田中将太, 芳賀昭弘, 武笠晃丈, 仲本宗泰, 鈴木雄一, 小池司, 北川陽介, 花大洵, 根城尭英, 野村昌志, 高柳俊作, 斎藤延人
    • Organizer
      第19回日本分子脳神経外科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 拡散画像を使ったconvolutional neural networkによる神経膠腫の悪性度診断2018

    • Author(s)
      高橋慧, 田中将太, 高橋渉, 仲本宗泰, 鈴木雄一, 北川陽介, 花大洵, 根城尭英, 野村昌志, 高柳俊作, 斎藤延人
    • Organizer
      日本脳神経外科学会第77回学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] CBCT image quality improvement using a deep convolutional neural network2018

    • Author(s)
      Kida S, Nakamoto T, Nakano M, Nawa K, Haga A, Kotoku J, Yamashita H, Nakagawa K
    • Organizer
      第115回医学物理学会学術大会
    • Related Report
      2018 Research-status Report
  • [Book] レディオミクス入門2021

    • Author(s)
      有村 秀孝, 角谷 倫之 編 (分担執筆: 仲本宗泰)
    • Total Pages
      338
    • Publisher
      オーム社
    • ISBN
      9784274226380
    • Related Report
      2021 Annual Research Report
  • [Remarks] 東京大学医学部附属病院 放射線科 放射線治療部門

    • URL

      http://u-tokyo-rad.jp/index.html

    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi