Elucidate the mechanism underlying the pediatric leukemogenesis associated with epigenetic alterations

• Project/Area Number: 18K15687
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: Tokai University (2020-2022); Showa University (2018-2019)
• Principal Investigator: Yamamoto Shohei 東海大学, 医学部, 准教授 (90439480)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 骨髄増殖性疾患 / 骨髄線維症 / 急性骨髄性白血病 / エピジェネティック制御関連遺伝子 / ASXL1遺伝子 / JAK2V617F / leukemogenesis / 骨髄異形成症候群 / ASXL1 / エピジェネティクス制御機構の破綻 / 骨髄繊維症 / エピジェネティック変異 / ASXL1遺伝子変異 / 本態性血小板血症 / ASXL1変異 / H3K27me3発現低下 / 小児AML / エピジェネティック制御機構 / 新規治療法開発

Outline of Final Research Achievements

The somatic mutation of JAK2V617F is present in >95% of polycythemia vera (PV) patients. PV patients with co-mutations of epigenetic regulators such as ASXL1 and JAK2V617F occurred myelofibrosis (MF) with poor prognosis. Asxl1 loss accelerates MF in JAK2V617F-driven myeloproliferative neoplasm (MPN) in mice. JAK2V617F;Asxl1+/- mice induces megakaryocytic hyperplasia and can transform to myeloid leukemia. Haploinsufficiency of Asxl1 and JAK2V617F trigger myeloid leukemia transformation through an additive effect to enhance H3K4me3 levels in the promoter region with oncogene.

Academic Significance and Societal Importance of the Research Achievements

骨髄増殖性疾患はJAK2V617F変異を高頻度に認める疾患であるが、近年、ASXL1などのエピジェネティック制御に関わる遺伝子変異が協調することで予後不良な骨髄線維症や骨髄性白血病を発症すると考えられている。本研究では、ヒトにおける疾患の特徴を明らかにすると同時に、モデルマウスにおいても同様の事象を確認しえた。また、疾患発症のメカニズムを解明し、至適薬剤を検討することで新規治療法開発につなげることが可能となり社会的意義を有する研究である。

Research Products

• [Int'l Joint Research] University of Miami(米国)
• [Int'l Joint Research] University of Miami(米国)
• [Int'l Joint Research] University of Miami(米国)
• [Journal Article] Novel TENM3–ALK fusion is an alternate mechanism for ALK activation in neuroblastoma (2022)
  • Author(s): Mitsuteru Hiwatari1, 2, 3, Masafumi Seki1, Ryosuke Matsuno4, Kenichi Yoshida5, Takeshi Nagasawa1, Aiko Sato-Otsubo1, Shohei Yamamoto6, Motohiro Kato1, Kentaro Watanabe1, Masahiro Sekiguchi1, Satoru Miyano7, Seishi Ogawa5, 8, 9, and Junko Takita10
  • Journal Title: Oncogene Volume: 41 Issue: 20 Pages: 2789
  • DOI: 10.1038/s41388-022-02301-1
  • Peer Reviewed
• [Journal Article] Post-chemotherapy immune status in infants with acute lymphoblastic leukemia: a report from the JPLSG MLL-10 trial (2022)
  • Author(s): Arakawa Y, Hasegawa D, Miyamura T, Oshima J, Kimura S, Imamura T, Koga Y, Yamamoto S, Ogawa A, Shinoda K, Nagai K, Hosoi H, Imai K, Koh K, Tomizawa D
  • Journal Title: Pediatr Blood Cancer Volume: 69 Issue: 10
  • DOI: 10.1002/pbc.29772
  • Peer Reviewed
• [Journal Article] Invasive pulmonary aspergillosis successfully treated with granulocyte transfusions followed by hematopoietic stem cell transplantation in a patient with severe childhood aplastic anemia (2022)
  • Author(s): Toyama D, Koganesawa M, Akiyama K, Yabe H, Yamamoto S
  • Journal Title: Tokai J Exp Clin Med Volume: 47 Pages: 136-138
  • Peer Reviewed
• [Journal Article] So-called bifocal tumors with diabetes insipidus and negative tumor markers: are they all germinoma? (2021)
  • Author(s): Kanamori M, Takami H, Kijima N, Terashima K, Ichimura K, Nishikawa R, et al,
  • Journal Title: Neuro-Oncology Volume: 23 Issue: 2 Pages: 295-303
  • DOI: 10.1093/neuonc/noaa199
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Successful combination chemotherapy involving clofarabine, cyclophosphamide, and etoposide for pediatric relapsed acute myeloid leukemia: A case report (2021)
  • Author(s): Fujita S, Matsuno R, Kawabata N, Sugishita Y, Kaneko R, Koganesawa M, Akiyama K, Toyama D, Yamamoto S
  • Journal Title: SAGE Open Med Case Rep Volume: 9 Pages: 1-4
  • DOI: 10.1177/2050313x211015511
  • Peer Reviewed / Open Access
• [Journal Article] Necessity for craniospinal irradiation of germinoma with positive cytology but without spinal leision on magnetic resonance images -A controversy (2021)
  • Author(s): Kanamori M, Takami H, Suzuki T ,Kijima N, Ichimura K, Nishikawa R, et al.
  • Journal Title: Neurooncol Adv Volume: 3(1) Issue: 1 Pages: 1-8
  • DOI: 10.1093/noajnl/vdab086
  • Peer Reviewed / Open Access
• [Journal Article] Anticoagulation treatment and prophylactic edoxaban for cerebral sinus venous thrombosis in an adolescent with acute lymphoblastic leukemia (2021)
  • Author(s): Koganesawa M, Matsuno R, Sugishita Y, Kaneko R, Kawabata N, Fujita S, Akiyama K, Toyama D, Yamamoto S
  • Journal Title: SAGE Open Med Case Rep Volume: 9 Pages: 1-4
  • DOI: 10.1177/2050313x211013225
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic value of the revised International Prognostic Scoing System five-group cytogenetic abnormalities classification for predicting the outcome of hematopoietic stem cell transplantation in pediatric myelodysplastic syndrome: JSHCT Pediatric MDS Working Group study (2021)
  • Author(s): Yamamoto S, Kato M, Watanabe K, Ishimaru S, Hasegawa D, Noguchi M, Hama A, Sato M, Koike T, Iwasaki F, Yagasaki H, Takahashi Y, Kosawa Y, Hashii Y, Morimoto A, Atsuta Y, Hasegawa D, Yoshida N
  • Journal Title: Bone Marrow Transplant Volume: 56 Issue: 12 Pages: 3016-3023
  • DOI: 10.1038/s41409-021-01446-z
  • Peer Reviewed
• [Journal Article] Myelodysplastic syndrome in a patient with IPEX syndrome (2021)
  • Author(s): Toyama D, Hoshino A, Inoue K, Kamiya T, Kanegane H, Yamamoto S
  • Journal Title: J Clin Immunol Volume: 41 Issue: 7 Pages: 1683-1685
  • DOI: 10.1007/s10875-021-01092-6
  • Peer Reviewed
• [Journal Article] Hematopoietic stem cell transplantation for pediatric acute promyelocytic leukemia in Japan (2020)
  • Author(s): Yamamoto S, Tomizawa D, Kudo K, Hasegawa D, Taga T, Yanada M, Kondo T, Nakazawa Y, Eto T, Inoue M, Kato K, Atsuta Y, Ishida H
  • Journal Title: Pediatr Blood Cancer Volume: 67 Issue: 5
  • DOI: 10.1002/pbc.28181
  • Peer Reviewed
• [Journal Article] Adolescent pulmonary metastatic neuroblastoma with ALK rearrangement: A case report (2020)
  • Author(s): Matsuno R, Akiyama K, Toyama D, Ikeda H, Yamamoto S
  • Journal Title: Pediatr Int Volume: 62 Issue: 4 Pages: 507-509
  • DOI: 10.1111/ped.14117
  • Peer Reviewed
• [Journal Article] Successful treatment of pediatric refractory/relapsed AML with KIR-ligand mismatched cord blood transplantation after FLAG-IDA re-induction therapy with or without the GO regimen (2020)
  • Author(s): Toyama D, Matsuno R, Sugishita Y, Kaneko R, Okamoto N, Koganesawa M, Fujita S, Akiyama K, Isoyama K, Yamamoto S
  • Journal Title: Case Rep Hematol Volume: 12 Pages: 1378056-1378056
  • DOI: 10.1155/2020/1378056
  • Peer Reviewed
• [Journal Article] Neurocognitive evaluation of Japanese childhood cancer survivors (2020)
  • Author(s): Akiyama K, Ikezawa S, Hasegawa Y, Sugisita Y, Kaneko R, Okamoto N, Koganesawa M, Fujita S, Matsuno R, Toyama D, Ikeda H, Yamamoto S
  • Journal Title: Showa Univ J Med Sci Volume: 32 Pages: 25-32
  • NAID: 130007837740
  • Peer Reviewed
• [Journal Article] 川崎病回復期に発症した免疫性血小板減少性紫斑病に対して免疫グロブリン大量療法が奏功した2例 (2020)
  • Author(s): 大塚康平, 山崎明香, 水野克己, 山本将平
  • Journal Title: 日本小児血液・がん学会雑誌 Volume: 57 Pages: 173-177
  • Peer Reviewed
• [Journal Article] 新生児遷延性肺高血圧症 (PPHN)を合併した一過性骨髄異常増殖症候群(TAM)の4例 (2020)
  • Author(s): 小金澤征也, 鈴木学, 城所励太, 金澤健, 村川哲郎, 櫻井基一郎, 山本将平, 水野克己
  • Journal Title: 日本周産期・新生児医学会雑誌 Volume: 56 Pages: 174-181
  • NAID: 130007841934
  • Peer Reviewed
• [Journal Article] Efficacy of hydroxyurea in a hypereosinophilic syndrome patient with significant eosinophilia (2020)
  • Author(s): 茂木 桜, 松野良介, 金子綾太, 岡本奈央子, 秋山康介, 外山大輔, 池田裕一, 山本将平
  • Journal Title: The Japanese Journal of Pediatric Hematology / Oncology Volume: 57 Issue: 5 Pages: 390-393
  • DOI: 10.11412/jspho.57.390
  • NAID: 130007986993
  • ISSN: 2187-011X, 2189-5384
  • Peer Reviewed
• [Journal Article] ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis (2019)
  • Author(s): Guy Y, Zhou Y, Yamamoto S, Yang H, Zhang P, Chen S, Nimer SD, Zhao Z, Xu M, Bai J, Yang FC.
  • Journal Title: Leukemia Volume: 33 Issue: 5 Pages: 1287-1291
  • DOI: 10.1038/s41375-018-0347-y
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Killer-cell immunoglobulin-like receptor ligand mismatch cord blood transplantation in high-risk neuroblastoma (2019)
  • Author(s): Matsuno R, Toyama D, Akiyama K, Isoyama K, Shiozawa E, Yamamoto S
  • Journal Title: Pediatr Int Volume: 61 Issue: 6 Pages: 566-571
  • DOI: 10.1111/ped.13861
  • Peer Reviewed
• [Journal Article] Gastric antral vascular ectasia in a pediatric patient with neuroblastoma who underwent tandem stem cell transplantation (2019)
  • Author(s): Sugishita Y, Yamamoto S, Kaneko R, Okamoto N, Koganesawa M, Fujita S, Akiyama K, Matsuno R, Toyama D, Isoyama K.
  • Journal Title: Blood Cell Therapy Volume: 2 Pages: 9-11
  • Peer Reviewed
• [Journal Article] Clinical and molecular characteristics of MEF2D fusion-positive B-cell precursor acute lymphoblastic leukemia in childhood, including a novel translocation resulting in MEF2D-HNRNPH1 gene fusion. (2019)
  • Author(s): Ohki K, Kiyokawa N, Hayashi Y, Koh K, Manabe A, Ohara A; Tokyo Children’s Cancer Study Group (TCCSG) et al.
  • Journal Title: Haematologica. Volume: 104(1) Issue: 1 Pages: 128-137
  • DOI: 10.3324/haematol.2017.186320
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chemotherapy ineffective for sacral stage 3 neuroblastoma: treatment strategy for tumors of favorable histology type (2019)
  • Author(s): 松野良介, 大貫裕太, 杉下友美子, 金子綾太, 小金澤征也, 藤田祥央, 岡本奈央子, 秋山康介, 外山大輔, 池田裕一, 土岐 彰, 山本将平
  • Journal Title: The Japanese Journal of Pediatric Hematology / Oncology Volume: 56 Issue: 5 Pages: 459-463
  • DOI: 10.11412/jspho.56.459
  • NAID: 130007795790
  • ISSN: 2187-011X, 2189-5384
  • Peer Reviewed
• [Journal Article] Gain-of-function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies (2018)
  • Author(s): Yang H, Kurtenbach S, Guo Y, Lohse I, Durante MA, Li J, Li Z, Al-Ali H, Li L, Chen Z, Field MG, Zhang P, Chen S, Yamamoto S, Li Z, Zhou Y, Nimer SD, Harbour JW, Wahlestedt C, Xu M, Yang FC
  • Journal Title: Blood Volume: 131 Issue: 3 Pages: 328-341
  • DOI: 10.1182/blood-2017-06-789669
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prophylactic recombinant thrombomodulin treatment prevents hepatic sinusoidal obstruction syndrome in high-risk pediatric patients that undergo hematopoietic stem cell transplants (2018)
  • Author(s): Yamamoto S, Toyama D, Sugishita Y, Kaneko R, Okamoto N, Koganesawa M, Fujita S, Akiyama K, Matsuno R, Isoyama K
  • Journal Title: Pediatric Transplantation Volume: e13269 Issue: 7
  • DOI: 10.1111/petr.13269
  • Peer Reviewed
• [Journal Article] Launch of “sweet home”, a group for parents of pediatric cancer patients (2018)
  • Author(s): 山本将平, 外山大輔, 杉下友美子, 金子綾太, 岡本奈央子, 小金澤征也, 藤田祥央, 秋山康介, 磯山恵一
  • Journal Title: The Japanese Journal of Pediatric Hematology / Oncology Volume: 55 Issue: 2 Pages: 182-186
  • DOI: 10.11412/jspho.55.182
  • NAID: 130007428021
  • ISSN: 2187-011X, 2189-5384
  • Peer Reviewed
• [Journal Article] THE ESTABLISHMENT OF THE PEDIATRIC・AYA CANCER CENTER AT SHOWA UNIVERSITY FUJIGAOKA HOSPITAL (2018)
  • Author(s): 山本将平, 外山大輔, 杉下友美子, 金子綾太, 岡本奈央子, 小金澤征也, 藤田祥央, 秋山康介, 磯山恵
  • Journal Title: Journal of The Showa University Society Volume: 78 Issue: 5 Pages: 513-519
  • DOI: 10.14930/jshowaunivsoc.78.513
  • NAID: 130007611146
  • ISSN: 2187-719X, 2188-529X
  • Peer Reviewed
• [Journal Article] Wiskott-Aldrich syndrome that was initially diagnosed as immune thrombocytopenic purpura secondary to a cytomegalovirus infection (2018)
  • Author(s): Kaneko R, Yamamoto S, Okamoto N, Akiyama K, Matsuno R, Toyama D, Hoshino A, Imai K, Isoyama K
  • Journal Title: SAGE Open Med Case Rep Volume: 6 Pages: 1-3
  • DOI: 10.1177/2050313x17753788
  • Peer Reviewed / Open Access
• [Journal Article] Initial presentation of lymphoblastic crisis in a pediatric chronic myelogenous leukemia patient (2018)
  • Author(s): 秋山康介, 山本将平, 杉下友美子, 金子綾太, 岡本奈央子, 小金澤征也, 藤田祥央, 松野良介, 外山大輔, 磯山恵一
  • Journal Title: Rinsho Ketsueki Volume: 59 Issue: 1 Pages: 75-79
  • DOI: 10.11406/rinketsu.59.75
  • NAID: 130006337949
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] Increased expression of interleukin-17 is associated with macrophages in chronic immune thrombocytopenia (2018)
  • Author(s): Okamoto N, Homma M, Kawaguchi Y, Kabasawa N, Uto Y, Hattori N, Yamamoto S, Shiozawa E, Yamochi T, Tate G, Isoyama K, Nakamaki T, Takimoto M
  • Journal Title: International Journal of Clinical and Experimental Pathology Volume: 11 Pages: 2419-2429
  • Peer Reviewed / Open Access
• [Journal Article] RecurrentRARBTranslocations in Acute Promyelocytic Leukemia LackingRARATranslocation (2018)
  • Author(s): Osumi Tomoo、Tsujimoto Shin-ichi、Tamura Moe、Uchiyama Meri、Nakabayashi Kazuhiko、、Takita Junko（22ｔｈ）、Inukai Takeshi、Ogawa Seishi、Kitamura Toshio、Matsumoto Kimikazu、Hata Kenichiro、Kiyokawa Nobutaka、Goyama Susumu、Kato Motohiro
  • Journal Title: Cancer Research Volume: 78 Issue: 16 Pages: 4452-4458
  • DOI: 10.1158/0008-5472.can-18-0840
  • Peer Reviewed
• [Journal Article] EVALUATION OF IL-17 EXPRESSION IN CHRONIC ITP USING IMMUNOHISTOCHEMICAL ANALYSIS (2018)
  • Author(s): 岡本奈央子, 本間まゆみ, 南雲佑, 川口有紀子, 蒲澤宣幸, 田澤咲子, 塩沢英輔, 矢持淑子, 楯玄秀, 瀧本雅文, 宇藤唯, 服部憲路, 中牧剛, 山本将平, 磯山恵一
  • Journal Title: Journal of The Showa University Society Volume: 78 Issue: 2 Pages: 111-116
  • DOI: 10.14930/jshowaunivsoc.78.111
  • NAID: 130007475058
  • ISSN: 2187-719X, 2188-529X
  • Peer Reviewed
• [Presentation] AYA神経芽腫症例に同定された新規TENM3-ALK融合遺伝子の機能解析 (2022)
  • Author(s): Hiwatari M, Seki M, Matsuno R, Yoshida K, Nagasawa T, Sato A, Yamamoto S, Miyano S, Seishi O, Takita J
  • Organizer: 第64回日本小児血液・がん学会学術集会
• [Presentation] 緊急椎弓切除により麻痺を回避し得た脊椎腫瘤を有するバーキットリンパ腫の1例 (2022)
  • Author(s): 矢野英俊, 杉下友美子, 川端奈央子, 藤田祥央, 秋山康介, 外山大輔, 小池隆志,山田佳之, 内山 温, 山本将平
  • Organizer: 第64回日本小児血液・がん学会学術集会
• [Presentation] 穏やかな経過で診断に至った皮下脂肪織炎様T細胞リンパ腫の1例 (2022)
  • Author(s): 柴田真由子, 杉下友美子, 川端奈央子, 藤田祥央, 秋山康介, 外山大輔, 小池隆志,山田佳之, 内山 温, 山本将平
  • Organizer: 第64回日本小児血液・がん学会学術集会
• [Presentation] 新規遺伝性骨髄不全Aldehyde degradation deficiency (ADD)症候群の2例 (2022)
  • Author(s): 杉下友美子, 柴田真由子, 川端奈央子, 藤田祥央, 秋山康介, 外山大輔, 山本将平, 小池隆志, 内山 温, 高田 穣, 矢部みはる, 矢部普正
  • Organizer: 第84回日本血液学会学術集会
• [Presentation] 進行速度が異なる2例の若年者Krabbe病に対する造血幹細胞移植 (2022)
  • Author(s): 柴田真由子, 杉下友美子,川端奈央子, 藤田祥央, 秋山康介, 外山大輔, 山本将平, 小池隆志, 内山 温, 矢部みはる, 矢部普正
  • Organizer: 第84回日本血液学会学術集会
• [Presentation] Prognostic factors of transplantation in the second remission for children with acute myeloid leukemia without prior transplantation (2022)
  • Author(s): Ishida H, Tsujimoto S, Hasegawa D, Sakaguchi H, Yamamoto S, Okamoto Y
  • Organizer: 64th ASH Annual Meeting and Exposotion
• [Presentation] ADLに対する造血細胞移植の適応 (2022)
  • Author(s): 小池隆志, 杉下友美子, 川端奈央子, 藤田祥央, 秋山康介, 外山大輔, 森本 克, 山本将平, 内山 温, 加藤俊一, 矢部みはる, 矢部普正
  • Organizer: 第44回日本造血・免疫細胞療法学会総会
• [Presentation] 同種造血細胞移植後の男性患者の妊孕能 (2022)
  • Author(s): 杉下友美子, 川端奈央子, 藤田祥央, 秋山康介, 外山大輔, 山本将平, 小池隆志, 森本 克, 内山 温, 加藤俊一, 矢部みはる, 矢部普正, 吉場史朗
  • Organizer: 第44回日本造血・免疫細胞療法学会総会
• [Presentation] 若年性骨髄単球性白血病に対する非血縁者間臍帯血移植と血縁者間HLAハプロ半合致移植の比較 (2022)
  • Author(s): 柳 将斗, 加藤元博, 山本将平, 渡邊健一郎, 濱 麻人, 小林良二, 佐藤真穂, 小倉妙美, 岡田恵子, 古賀友紀, 田渕 健, 橋井佳子, 加藤剛二, 熱田由子, 吉田奈央
  • Organizer: 第44回日本造血・免疫細胞療法学会総会
• [Presentation] 長期の経過観察を行なった造血細胞移植後transplant-acquired food allergy (TAFA)の2 例 (2021)
  • Author(s): 柴田真由子, 杉下友美子, 川端奈央子, 藤田祥央, 秋山康介, 外山大輔, 山本将平, 小池隆志, 矢部みはる, 矢部普正
  • Organizer: 第63回日本小児血液・がん学会学術集会
• [Presentation] Allogeneic stem cell transplantation for the treatment of mucopolysaccharidosis ⅣA (2021)
  • Author(s): Yabe H, Kawabata N, Fujita S, Akiyama K, Toyama D, Yamamoto S, Koike T, Uchiyama A
  • Organizer: 第62回日本先天性代謝異常学会学術集会
• [Presentation] 乳幼児期にfull-dose Buレジメンで移植し、成人した女性の性腺機能 (2021)
  • Author(s): 川端奈央子, 杉下友美子, 柴田真由子, 藤田祥央, 秋山康介, 外山大輔, 山本将平, 小池隆志, 矢部みはる, 矢部普正
  • Organizer: 第63回日本小児血液・がん学会学術集会
• [Presentation] 再発難治AML患者のiTAMに対して高圧酸素療法が有効であった一例 (2021)
  • Author(s): Iizuka A, Tsujimoto S, Tanoshima R, Hayashi H, Takeuchi M, Enaka M, Koike T, Yamamoto S, Yamanaka S, Shiba N
  • Organizer: 第63回日本小児血液・がん学会学術集会 2021.11.25
• [Presentation] Brothers with Fanconi anemia showing different ALDH2 mutations (2021)
  • Author(s): Fujita S, Sugishita Y, Kaneko R, Akiyama K, Toyama D, Koganesawa M, Otsubo K, Koike T, Yamamoto S, Mochizuki H, Yabe M, Yabe H
  • Organizer: 第83回日本血液学会学術集会
• [Presentation] Alternative-donor bone marrow transplantation in four half-Japanese children (2021)
  • Author(s): Yamamoto S, Fujita S, Sugishita Y, Kaneko R, Akiyama K, Toyama D, Koganesawa M, Otsubo K, Koike T, Mochizuki H, Yabe M, Yabe H
  • Organizer: 第83回日本血液学会学術集会
• [Presentation] 骨髄採取シミュレーターの開発 (2021)
  • Author(s): 小池隆志, 今井枝里, 大坪慶輔, 秋山康介, 外山大輔, 金子綾太, 藤田祥央, 小金澤征也, 山本将平, 望月博之, 矢部普正
  • Organizer: 第43回日本造血細胞移植学会総会
• [Presentation] Full-dose BUによるBMT後に精子を保存し、TBIを含む再移植後に凍結精子で妊娠した1例 (2021)
  • Author(s): 秋山康介, 森本克, 小池隆志, 今井枝里, 外山大輔, 金子綾太, 藤田祥央, 小金澤征也, 山本将平, 望月博之, 矢部普正
  • Organizer: 第43回日本造血細胞移植学会総会
• [Presentation] 臍帯血移植後に著名なADLの改善を得た進行期Krabbe病の1例 (2020)
  • Author(s): 金子綾太, 小池隆志, 今井枝里, 大坪慶輔, 秋山康介, 外山大輔, 小金澤征也, 山本将平, 望月博之, 矢部普正
  • Organizer: 第61回日本小児血液・がん学会学術集会
• [Presentation] HHV-6の再活性化に伴って著名な肝障害を認めたハプロ移植の1例 (2020)
  • Author(s): 外山大輔, 小池隆志, 今井枝里, 大坪慶輔, 秋山康介, 金子綾太, 小金澤征也, 山本将平, 望月博之, 矢部普正
  • Organizer: 第61回日本小児血液・がん学会学術集会
• [Presentation] UBMT後のDLIは肝細胞障害型GVHDを起こしうる (2020)
  • Author(s): 小池隆志, 今井枝里, 大坪慶輔, 秋山康介, 外山大輔, 金子綾太, 藤田祥央, 小金澤征也, 山本将平, 矢部普正
  • Organizer: 第61回日本小児血液・がん学会学術集会
• [Presentation] 小児再発難治性AMLに対するFLAG+IDA+GOによる再寛解導入後のKIRリガンドミス マッチ臍帯血移植の良好な治療成績 (2018)
  • Author(s): 山本将平
  • Organizer: 第10回血液疾患免疫療法学会学術集会
• [Presentation] 小児MDSにおけるR-IPSSに基づいた染色体異常と造血細胞移植成績の関連 (2018)
  • Author(s): 山本将平
  • Organizer: 第23回小児MDS治療研究会
• [Presentation] HEMATOPOIETIC CELL TRANSPLANTATION WITH UNIFIED CONDITIONING BASED ON MINIMAL RESIDUAL DISEASE FOR INTERMEDIATE-RISK RELAPSE OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA: RESULTS FROM THE JPLSG R08-II STUDY (2018)
  • Author(s): Ueki H, Ogawa C, Toyoda H, Nishi M, Yamanaka J, Mochizuki S, Yamamoto S, Nishikawa T, Sakaguchi K, Kobayashi S, Arakawa A, Nishiuchi R, Yoshida S, Nakamura K, Hori T, Saito A, Watanabe T, Goto H
  • Organizer: SIOP
  • Int'l Joint Research
• [Presentation] RARB Translocations in RARA-negative acute promyelocytic leukemia (2018)
  • Author(s): Kato M, Osumi T, Tsujimoto S, Tamura M, Uchiyama M, Nakabayashi K, Okamura K, Tomizawa D, Watanabe A, Takahashi H, Hori T, Yamamoto S, Hamamoto K, Migita M, Ogata-Kawata H, Uchiyama T, Kizawa H, Ueno-Yokohata H, Shirai R, Yoshida M, Seki M, Oki K, Takita J, Ogawa S, Kitamura T, Matsumoto K, Hata K, Goyama S, Kiyokawa N
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Neurocognitive evaluation of Japanese childhood cancer survivors (2018)
  • Author(s): Akiyama K, Yamamoto S, Sugisita Y, Kaneko R, Okamoto N, Koganesawa M, Fujita S, Matsuno R, Toyama D, Hasegawa Y, Setoyama S, Ikezawa S, Noda T, Isoyama K
  • Organizer: 第80回日本血液学会学術集会
• [Book] 汎血球減少の鑑別. 小児で経験する「血液の異常」 (2021)
  • Author(s): 山本将平
  • Total Pages: 6
  • Publisher: 東京医学社
• [Book] 【小児の貧血】ヘモグロビン異常症の診断と治療 (2020)
  • Author(s): 山本将平
  • Total Pages: 7
  • Publisher: 金原出版株式会社