Roles of cytomegalovirus in refractory inflammatory bowel disease
| Project/Area Number |
18K15747
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53010:Gastroenterology-related
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| Research Institution | Kyoto University |
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Principal Investigator |
Yamamoto Shuji 京都大学, 医学研究科, 特定病院助教 (00789638)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 炎症性腸疾患 / 潰瘍性大腸炎 / サイトメガロウイルス / ulcerative colitis / cytomegalovirus |
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| Outline of Final Research Achievements |
Our objective was to elucidate the roles of cytomegalovirus (CMV) in refractory inflammatory bowel disease (IBD), using T cell receptor α knock out mice infected with murine CMV.
We found 1) the mouse model we used replicated phenotypes of human refractory IBD with CMV reactivation and 2) the infection of murine CMV altered Th2 dominant T cell differentiation in the inflamed colonic mucosa toward Th1/17 dominant one in T cell receptor α knock out mice.
Our mouse model could be useful for further elucidation of the mechanism by which CMV infection influences the response to medical therapies in patients with IBD.
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| Academic Significance and Societal Importance of the Research Achievements |
炎症性腸疾患(inflammatory bowel disease, IBD) には治療に難渋する重症例、治療抵抗例が存在する。サイトメガロウイルス(cytomegalovirus, CMV) は、IBD、特に潰瘍性大腸炎における重症化、難治化の要因の1 つと考えられているが、その機序については明らかでない。
本研究では、ヒトIBD 患者におけるCMV 再活性化例と類似した治療抵抗性を示すCMV感染合併IBDマウスモデルを確立することに成功した。このマウスモデルを使用することでIBDにおける難治化のメカニズムを詳細に検討することが可能となった。
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Report
(4 results)
Research Products
(23 results)
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[Presentation] HYA,A Metabolite of Linoleic Acid by the Commensal Bacteria, Ameliorates Colonic Inflammation in IL-10-deficient Mice Through the Alteration of Macrophage Function2019
Author(s)
Makoto Okabe, Minoru Matsuura, Hiroki Kitamoto,Satoshi Yamada,Yusuke Honzawa, Shuji Yamamoto, Hiroshi Seno, Shigenobu Kishino,Jun Ogawa
Organizer
Digestive disease week 2019
Related Report
Int'l Joint Research
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