Significance of glucagon in the development of colon cancer in diabetic patients
| Project/Area Number |
18K15791
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53010:Gastroenterology-related
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| Research Institution | Nagoya City University |
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Principal Investigator |
Yagi Takashi 名古屋市立大学, 医薬学総合研究院(医学), 研究員 (00781840)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | グルカゴン / 大腸癌 / 大腸癌細胞 |
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| Outline of Final Research Achievements |
Many papers have shown that diabetes patients are associated with cancer risk. In addition, the highest mortality of diabetes is cancer. However how diabetes increases the risk has not been well understood.
In this study we demonstrated glucagon receptor expressed some human colon cancer tissues, human colon cancer cell lines and mouse colon cancer cell lines. Glucagon promoted cell growth via AMP-activated protein kinase and mitogen-activated protein kinase.
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| Academic Significance and Societal Importance of the Research Achievements |
今までグルカゴンと癌に関する研究についてはほぼ皆無であった。本研究により、高グルカゴンが大腸癌細胞増殖を促進することが示され、グルカゴンの持つ新たなメカニズムが明らかとなった。グルカゴンという新たな切り口から糖尿病と大腸がんの関連について新しい知見が得られ、糖尿病患者における大腸がんの罹患リスク低減や珍奇治療法の開発に今後貢献しうると考えられる。
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Report
(5 results)
Research Products
(1 results)
