An Exploratory Research for Effective and Efficient Clinical Practice of Heart Failure Using Wearable Devices

• Project/Area Number: 18K15860
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Keio University
• Principal Investigator: SHIRAISHI Yasuyuki 慶應義塾大学, 医学部(信濃町), 特任助教 (00752700)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 心不全 Heart Failure / 生活の質 Quality of Life / 身体活動 Physical Activity / 加速度計 Accelerometer / Patient Reported Outcome / Sedentary Time / Advance Care Planning / Prognosis / 心不全関連QOL / 予後情報 / 心不全 / ウェアラブル端末 / 医療者患者間ギャップ / 質問紙票 / 在宅活動量 / 活動量 / 質問票 / 再入院予防

Outline of Final Research Achievements

This study investigated the agreement between the level of physical activity assessed by the Kansas City Cardiomyopathy Questionnaire (KCCQ) and accelerometer in hospitalized heart failure (HF) patients. The patients wore a validated three-axis accelerometer for 2 weeks and completed the short version of the KCCQ. The association of the KCCQ findings (summary and individual domains) with accelerometer-measured parameters was evaluated. Daily steps, exercise time (metabolic equivalents × hours), and %sedentary time were measured. A strong correlation was seen between %sedentary time and the KCCQ results. All the KCCQ individual domains (physical limitation, symptom frequency, and QoL), except the social limitation domain, showed good correlations with %sedentary time. Accelerometer-assessed physical activity strongly correlated with the overall KCCQ score. Therefore, the accelerometer can complement the KCCQ results in accurately assessing the physical activity in HF patients.

Academic Significance and Societal Importance of the Research Achievements

健康関連QOLは症状、身体活動度やメンタルヘルス等を包括する概念であり、循環器領域においても生命予後と並んで重要な治療目標である。これらは現在、質問紙票を用いて評価されることが一般的だが、昨今はデジタル機器を用いた評価法が探索的に実施されつつある。中でも3軸加速度センサ搭載型の高精度活動量計は、客観的かつ長期間に渡って身体活動を評価することが可能である。
今回の研究で加速度計データと心不全患者の全般的なQOL指標に強い相関が認められており、このようなデジタル機器を用いた客観的評価は実臨床ならびに臨床試験の重要な評価項目になり得ると考えられる。

Research Products

• [Journal Article] Abnormal Liver Function Tests and Long-Term Outcomes in Patients Discharged after Acute Heart Failure (2021)
  • Author(s): Miyama Hiroshi、Shiraishi Yasuyuki、Kohsaka Shun、Goda Ayumi、Nishihata Yosuke、Nagatomo Yuji、Takei Makoto、Fukuda Keiichi、Kohno Takashi、Yoshikawa Tsutomu
  • Journal Title: Journal of Clinical Medicine Volume: 10 Issue: 8 Pages: 1730-1730
  • DOI: 10.3390/jcm10081730
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Time-sensitive approach in the management of acute heart failure (2021)
  • Author(s): Yasuyuki Shiraishi, Masataka Kawana, Jun Nakata, Naoki Sato, Keiichi Fukuda, Shun Kohsaka
  • Journal Title: ESC Heart Failure Volume: 8 Issue: 1 Pages: 204-221
  • DOI: 10.1002/ehf2.13139
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic Understanding and Preference for the Communication Process with Physicians in Hospitalized Heart Failure Patients (2021)
  • Author(s): Kitakata Hiroki、Kohno Takashi、Kohsaka Shun、Fujisawa Daisuke、Nakano Naomi、Shiraishi Yasuyuki、Katsumata Yoshinori、Yuasa Shinsuke、Fukuda Keiichi
  • Journal Title: Journal of Cardiac Failure Volume: 27 Issue: 3 Pages: 318-326
  • DOI: 10.1016/j.cardfail.2020.10.009
  • Peer Reviewed
• [Journal Article] Derivation and Validation of Clinical Prediction Models for Rapid Risk Stratification for Time-Sensitive Management for Acute Heart Failure (2020)
  • Author(s): Shiraishi Yasuyuki、Kohsaka Shun、Abe Takayuki、Nagai Toshiyuki、Goda Ayumi、Nishihata Yosuke、Nagatomo Yuji、Saji Mike、Toyosaki Yuichi、Takei Makoto、Kitai Takeshi、Kohno Takashi、Fukuda Keiichi、Matsue Yuya、Anzai Toshihisa、Yoshikawa Tsutomu
  • Journal Title: Journal of Clinical Medicine Volume: 9 Issue: 11 Pages: 3394-3394
  • DOI: 10.3390/jcm9113394
  • Peer Reviewed / Open Access
• [Journal Article] Natriuretic Peptide Measurement is Key to a Solution in the Clinical Trial and Clinical Practice (2020)
  • Author(s): Mizuki Momoi, Yasuyuki Shiraishi, Shun Kohsaka, Keiichi Fukuda, Tsutomu Yoshikawa
  • Journal Title: JACC: Heart Failure Volume: 8 Issue: 9 Pages: 782-783
  • DOI: 10.1016/j.jchf.2020.06.011
  • Peer Reviewed
• [Journal Article] Prognostic Implications of Early and Midrange Readmissions After Acute Heart Failure Hospitalizations: A Report From a Japanese Multicenter Registry (2020)
  • Author(s): Kitakata Hiroki、Kohno Takashi、Kohsaka Shun、Shiraishi Yasuyuki、Parizo Justin T.、Niimi Nozomi、Goda Ayumi、Nishihata Yosuke、Heidenreich Paul A.、Yoshikawa Tsutomu
  • Journal Title: Journal of the American Heart Association Volume: 9 Issue: 10
  • DOI: 10.1161/jaha.119.014949
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prediction of sudden cardiac death in Japanese heart failure patients: international validation of the Seattle Proportional Risk Model (2020)
  • Author(s): Fukuoka Ryoma、Kohno Takashi、Kohsaka Shun、Shiraishi Yasuyuki、Sawano Mitsuaki、Abe Takayuki、Nagatomo Yuji、Goda Ayumi、Mizuno Atsushi、Fukuda Keiichi、Shadman Ramin、Dardas Todd F、Levy Wayne C、Yoshikawa Tsutomu
  • Journal Title: EP Europace Volume: 22 Issue: 4 Pages: 588-597
  • DOI: 10.1093/europace/euaa002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Optimal sampling in derivation studies was associated with improved discrimination in external validation for heart failure prognostic models (2020)
  • Author(s): Iwakami Naotsugu、Nagai Toshiyuki、Furukawa Toshiaki A.、Ogata Soshiro、Nakai Michikazu、Takegami Misa、Nakano Hiroki、Kawasaki Yohei、Alba Ana Carolina、Guyatt Gordon Henry、Shiraishi Yasuyuki、Kohsaka Shun、Kohno Takashi、Goda Ayumi、Yoshikawa Tsutomu、Anzai Toshihisa
  • Journal Title: Journal of Clinical Epidemiology Volume: 121 Pages: 71-80
  • DOI: 10.1016/j.jclinepi.2020.01.011
  • Peer Reviewed
• [Journal Article] Prognostic Impact of Previous Hospitalization in Acute Heart Failure Patients (2019)
  • Author(s): Akita Keitaro、Kohno Takashi、Kohsaka Shun、Shiraishi Yasuyuki、Nagatomo Yuji、Goda Ayumi、Mizuno Atsushi、Sujino Yasumori、Fukuda Keiichi、Yoshikawa Tsutomu、West Tokyo Heart Failure Registry Investigators
  • Journal Title: Circulation Journal Volume: 83 Issue: 6 Pages: 1261-1268
  • DOI: 10.1253/circj.CJ-18-1087
  • NAID: 130007652736
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-05-24
  • Peer Reviewed
• [Journal Article] Long-Term Outcomes According to Etiology May Alter Under Different Circumstances (2019)
  • Author(s): Shoji S, Shiraishi Y, Fukuda K, Yoshikawa T, Kohsaka S.
  • Journal Title: JACC Heart Failure Volume: 8 Issue: 1 Pages: 83-84
  • DOI: 10.1016/j.jchf.2019.08.021
  • Peer Reviewed
• [Journal Article] Clinical implications of the blood urea nitrogen/creatinine ratio in heart failure and their association with haemoconcentration (2019)
  • Author(s): Sujino Yasumori、Nakano Shintaro、Tanno Jun、Shiraishi Yasuyuki、Goda Ayumi、Mizuno Atsushi、Nagatomo Yuji、Kohno Takashi、Muramatsu Toshihiro、Nishimura Shigeyuki、Kohsaka Shun、Yoshikawa Tsutomu、for the West Tokyo Heart Failure Registry Investigators
  • Journal Title: ESC Heart Failure Volume: 6 Issue: 6 Pages: 1274-1282
  • DOI: 10.1002/ehf2.12531
  • Peer Reviewed / Open Access
• [Journal Article] Heart Failure With Midrange Ejection Fraction in Patients Admitted for Acute Decompensation: A Report from the Japanese Multicenter Registry (2019)
  • Author(s): Takei Makoto、Kohsaka Shun、Shiraishi Yasuyuki、Goda Ayumi、Nagatomo Yuji、Mizuno Atsushi、Suzino Yasumori、Kohno Takashi、Fukuda Keiichi、Yoshikawa Tsutomu
  • Journal Title: Journal of Cardiac Failure Volume: 25 Issue: 8 Pages: 666-673
  • DOI: 10.1016/j.cardfail.2019.05.010
  • Peer Reviewed
• [Journal Article] Length of hospital stay and its impact on subsequent early readmission in patients with acute heart failure: a report from the WET-HF Registry (2019)
  • Author(s): Moriyama Hidenori、West Tokyo Heart Failure Registry Investigators、Kohno Takashi、Kohsaka Shun、Shiraishi Yasuyuki、Fukuoka Ryoma、Nagatomo Yuji、Goda Ayumi、Mizuno Atsushi、Fukuda Keiichi、Yoshikawa Tsutomu
  • Journal Title: Heart and Vessels Volume: 34 Issue: 11 Pages: 1777-1788
  • DOI: 10.1007/s00380-019-01432-y
  • Peer Reviewed
• [Journal Article] Discrepancy between patient-reported quality of life and the prognostic assessment of Japanese patients hospitalized with acute heart failure (2019)
  • Author(s): Shoji Satoshi、Shiraishi Yasuyuki、Sawano Mitsuaki、Katsumata Yoshinori、Yuasa Shinsuke、Kohno Takashi、Fukuda Keiichi、Spertus John A.、Kohsaka Shun
  • Journal Title: Heart and Vessels Volume: 印刷中 Issue: 9 Pages: 1464-1470
  • DOI: 10.1007/s00380-019-01378-1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Validation and Recalibration of Seattle Heart Failure Model in Japanese Acute Heart Failure Patients (2018)
  • Author(s): Shiraishi Y, Kohsaka S, Nagai T, Goda A, Mizuno A, Nagatomo Y, Sujino Y, Fukuoka R, Sawano M, Kohno T, Fukuda K, Anzai T, Shadman R, Dardas T, Clevy W, Yoshikawa T
  • Journal Title: J Card Fail Volume: 999 Issue: 7 Pages: 999-999
  • DOI: 10.1016/j.cardfail.2018.07.463
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Effect of Multiple Comorbidities on Application of Guideline-Directed Medical Therapy in Hospitalized Heart Failure Patients (2021)
  • Author(s): 竹内真介、合田あゆみ、河野隆志、副島京子、白石泰之、佐地真育、武井眞、西畑庸介、中埜信太郎、長友祐司、香坂俊、吉川勉
  • Organizer: 第85回日本循環器学会学術集会
• [Presentation] Treatment Gaps in Heart Failure Patients with Malnutrition (2021)
  • Author(s): 川久保裕美子、白石泰之、合田あゆみ、河野隆志、長友祐司、佐地真育、西畑庸介、武井眞、中埜信太郎、池上幸憲、香坂俊、福田恵一、吉川勉
  • Organizer: 第85回日本循環器学会学術集会
• [Presentation] Patient Perspectives on Their Self-Care Behavior after Heart Failure Hospitalization (2021)
  • Author(s): 橋本俊、北方博規、河野隆志、香坂俊、白石泰之、関根乙矢、岸野喜一、勝俣良紀、湯浅慎介、福田恵一
  • Organizer: 第85回日本循環器学会学術集会
• [Presentation] 心不全患者へ対する非侵襲的生体センサを用いた多角的生体情報遠隔モニタリング (2020)
  • Author(s): 白石泰之、川久保裕美子、片岡雅晴、勝俣良紀、中野直美、香坂俊、福田恵一
  • Organizer: 第24回日本心不全学会学術集会
  • Invited
• [Presentation] 心不全入院患者の予後理解と予後についての医師との対話に関する希望 (2020)
  • Author(s): 北方博規、河野隆志、香坂俊、中野直美、白石泰之、勝俣良紀、湯浅慎介、福田恵一
  • Organizer: 第24回日本心不全学会学術集会
• [Presentation] ガイドラインが推奨する診療を高齢者心不全に対してどう実践すべきか (2020)
  • Author(s): 河野隆志、香坂俊、白石泰之、合田あゆみ、西畑庸介、佐地真育、武井眞、長友祐司、吉川勉
  • Organizer: 第24回日本心不全学会学術集会
  • Invited
• [Presentation] 心不全緩和ケア・アドバンスケアプラニングをリスクモデルという観点から再考する (2020)
  • Author(s): 河野隆志、香坂俊、白石泰之、北方博規、庄司聡、水野篤、吉川勉
  • Organizer: 第24回日本心不全学会学術集会
  • Invited
• [Presentation] 絶対リスクに基づく急性心不全診療 (2020)
  • Author(s): 白石泰之、香坂俊、合田あゆみ、長友祐司、佐地真育、西畑庸介、武井眞、河野隆志、福田恵一、吉川勉
  • Organizer: 第24回日本心不全学会学術集会
  • Invited
• [Presentation] State-of-Art Treatment for Acute Cardiogenic Pulmonary Edema Patients (2020)
  • Author(s): 白石泰之、香坂俊、川名正隆、中田淳、佐藤直樹、福田恵一
  • Organizer: 第24回日本心不全学会学術集会
  • Invited
• [Presentation] 日本の心臓移植システムとMCSの使い方 (2020)
  • Author(s): 白石泰之
  • Organizer: 第24回日本心不全学会学術集会
  • Invited
• [Presentation] 心不全患者における入院中のBasic Activities of Daily Living (BADL) 低下に関連する因子 (2020)
  • Author(s): 福井奨悟、川上途之、白石泰之、中村拓也、岩沢達也、岸野喜一、勝俣良紀、湯浅慎介、香坂俊、福田恵一
  • Organizer: 第24回日本心不全学会学術集会
• [Presentation] Alteration in Diuretic Strategy after an Update on the Clinical Practice Guideline Recommendations for Acute Heart Failure Management in Japan (2020)
  • Author(s): 山崎雄友、白石泰之、香坂俊、合田あゆみ、長友祐司、西畑庸介、佐地真育、武井眞、豊崎雄一、池上幸憲、河野隆志、福田恵一、吉川勉
  • Organizer: 第24回日本心不全学会学術集会
• [Presentation] Association of Short-Acting Versus Long-Acting Loop Diuretics With Long-term Outcomes in Patients Hospitalized for Acute Heart Failure (2020)
  • Author(s): 今枝昇平、白石泰之、新美望、合田あゆみ、長友祐司、西畑庸介、武井眞、豊崎雄一、池上幸憲、河野隆志、福田恵一、香坂俊、吉川勉
  • Organizer: 第24回日本心不全学会学術集会
• [Presentation] Gaps in Provision of Guideline-Based Medical Therapy in Hospitalized Heart Failure with Malnutrition: A Report from the WET-HF Registry (2020)
  • Author(s): 川久保裕美子、白石泰之、合田あゆみ、長友祐司、西畑庸介、佐地真育、武井眞、豊崎雄一、池上幸憲、庄司聡、河野隆志、福田恵一、香坂俊、吉川勉
  • Organizer: 第24回日本心不全学会学術集会
• [Presentation] Measurement of Discharge Natriuretic Peptide Levels and its Association with the Outcomes in Hospitalized Heart Failure Patients (2020)
  • Author(s): 桃井瑞樹、白石泰之、合田あゆみ、長友祐司、西畑庸介、佐地真育、武井眞、豊崎雄一、池上幸憲、河野隆志、福田恵一、香坂俊、吉川勉
  • Organizer: 第24回日本心不全学会学術集会
• [Presentation] 第二世代 急性心不全患者 予後予測システムの構築：画像情報とその深層学習の応用 (2020)
  • Author(s): 白石泰之
  • Organizer: 第84回日本循環器学会学術集会
  • Invited
• [Presentation] Prognostic communication with hospitalized heart failure patients; the patients' perspective (2019)
  • Author(s): Kitakata H, Kohno T, Kohsaka S, Fujisawa D, Nakano N, Shiraishi Y, Katsumata Y, Yuasa S, Fukuda K
  • Organizer: 欧州心臓病学会2019
  • Int'l Joint Research
• [Presentation] 急性心不全と身体活動、関連する病態生理 (2018)
  • Author(s): 白石泰之
  • Organizer: 第22回日本心不全学会学術集会
• [Presentation] Patient perspective on life-style modification and knowledge of worsening symptom in cardiovascular diseases (2018)
  • Author(s): 河野隆志、中野直美、白石泰之、北方博規、福田恵一
  • Organizer: 第22回日本心不全学会学術集会
• [Book] 心不全診療アップグレード (2021)
  • Author(s): 佐藤幸人、白石泰之、他
  • Total Pages: 283
  • Publisher: 日本医事新報社
• [Book] INTENSIVIST［循環器集中治療Critical Care Cardiology］ (2021)
  • Author(s): 香坂俊、白石泰之、他
  • Total Pages: 200
  • Publisher: メディカル・サイエンス・インターナショナル
• [Book] 治療［プライマリ・ケア医が知っておくべき心不全診療］ (2020)
  • Author(s): 弓野大、白石泰之、他
  • Total Pages: 166
  • Publisher: 南山堂
• [Book] Hospitalist (2019)
  • Author(s): 平岡 栄治、上月 周、杉崎 陽一郎、白石泰之、他
  • Total Pages: 200
  • Publisher: メディカル・サイエンス・インターナショナル
  • ISBN: 9784895929561
• [Book] 心不全（第2版） 上 最新の基礎・臨床研究の進歩 (2018)
  • Author(s): 筒井 裕之、白石泰之、他
  • Total Pages: 720
  • Publisher: 日本臨床社