Research to establish a highly accurate and non-invasive method of assessing the risk of developing ischemic heart disease based on the pathophysiology of ischemic heart disease

• Project/Area Number: 18K15872
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Hosoda Hayato 国立研究開発法人国立循環器病研究センター, 心臓血管内科, 客員研究員 (60617801)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2019: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: NIRS / MRI / プラーク / D-SPECT / 冠動脈MRI / 虚血性心臓病 / MRIプラークイメージング

Outline of Final Research Achievements

To elucidate the pathophysiology of coronary artery plaques associated with the development of ischemic heart disease, we conducted studies of coronary artery plaques using MRI and intracoronary imaging (NIRS IVUS). First, we reported that coronary hyperintense plaque volume detected by MRI predicts the risk of perioperative myocardial infarction during catheterization (J Cardiovasc Magn Reson 2020;22:5.) Furthermore, the association between lipid components and coronary events in calcified lesions related to the development of coronary artery disease was investigated and reported using NIRS-IVUS (Int J Cardiovasc Imaging. 2023 Jun 28.).

Academic Significance and Societal Importance of the Research Achievements

MRIとNIRS-IVUSをもちいて冠動脈プラークの性状について解明することが、虚血性心臓病の病態生理の解明につながると思われる。病態を理解することは、さらに低侵襲で高精度な虚血性心疾患の発症リスクの推定法の開発につながる。最終的には正確に発症リスク推定ができれば、発症リスクに応じた適切な予防法を行うことにつながっていくと思われる。

Research Products

• [Journal Article] Three-dimensional assessment of coronary high-intensity plaques with T1-weighted cardiovascular magnetic resonance imaging to predict periprocedural myocardial injury after elective percutaneous coronary intervention. (2020)
  • Author(s): Hosoda H, Asaumi Y, Noguchi T, Morita Y, Kataoka Y, Otsuka F, Nakao K, Fujino M, Nagai T, Nakai M, Nishimura K, Kono A, Komori Y, Hoshi T, Sato A, Kawasaki T, Izumi C, Kusano K, Fukuda T, Yasuda S.
  • Journal Title: J Cardiovasc Magn Reson. Volume: 22 Issue: 1 Pages: 5-5
  • DOI: 10.1186/s12968-019-0588-6
  • NAID: 120007133004
  • Peer Reviewed / Open Access
• [Journal Article] Severely calcified lipidic atheroma on intravascular ultrasound and near-infrared spectroscopy imaging: its association with slow-flow phenomenon during percutaneous coronary intervention (2019)
  • Author(s): Hosoda Hayato、Kataoka Yu、Otsuka Fuimyuki、Yasuda Satoshi
  • Journal Title: European Heart Journal - Case Reports Volume: 3 Issue: 2 Pages: 1-2
  • DOI: 10.1093/ehjcr/ytz078
  • Peer Reviewed / Open Access