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The role of microbiome and TMAO in patients with acute myocardial infarction

Research Project

Project/Area Number 18K15896
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53020:Cardiology-related
Research InstitutionYokohama City University

Principal Investigator

Matsuzawa Yasushi  横浜市立大学, 附属市民総合医療センター, 講師 (90600635)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords動脈硬化 / 心筋梗塞 / 腸内細菌 / 血小板作用 / 心血管イベント / myocardial infarction / microbiome / follow up study / secondary prevention / residual risk / 急性心筋梗塞 / 腸内細菌叢
Outline of Final Research Achievements

Trimethylamine N-oxide (TMAO), a metabolite derived from the gut microbiota, is proatherogenic
and associated with cardiovascular events. We included STEMI patients and measured plasma TMAO levels at the onset of STEMI and 10 months later (chronic phase). The chronic-phase TMAO level was associated with coronary atherosclerosis progression and independently predicted future cardiovascular events. Furthermore, high microbiome diversity was significantly associated with low platelet-derived thrombogenicity 1h after administration of antithrombotic agents in patients with STEMI. These data suggest that the clinical importance of gut microbiome and its' metabolite, TMAO, on future cardiovascular events in patients after STEMI.

Academic Significance and Societal Importance of the Research Achievements

心筋梗塞、脳梗塞は主要な死因であり、死亡だけでなく患者に障害を残し、介護需要、医療需要に占める割合も大きい。動脈硬化性疾患の主要な原因として、糖尿病や高コレステロール血症、高血圧などがあるがその原因はまだ半分も解明されていない。腸内細菌叢は宿主の代謝や炎症と重要に関与することが最近わかってきており、動脈硬化性疾患の一つの重要な原因となる可能性がある。今回の我々の研究結果により、腸内細菌叢と動脈硬化性疾患の関連が明らかになってきた。動脈硬化性疾患の新たな介入ターゲットとなる可能性があり今後の更なる研究によって調査される必要がある。

Report

(4 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (2 results)

All 2021 2019

All Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] Impact of firmicutes to bacteroidetes ratio on the cardiovascular events in male patients with acute myocardial infarction2021

    • Author(s)
      H. Nakahashi, Y. Matsuzawa, K. Hibi, N. Iwahashi, N. Maejima, K. Okada, Y. Kimura, E. Akiyama, Y. Minamimoto, Y. Ogino, R. Satou, M. Kosuge, K. Tamura, K. Kimura
    • Organizer
      日本循環器学会総会2021年
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Microbiota-derived Trimethylamine N-oxide (TMAO) as Residual Risk after ST-elevation Myocardial Infarction2019

    • Author(s)
      松澤泰志
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2024-01-30  

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