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Establishment of a CKD treatment with short-chain fatty acids

Research Project

Project/Area Number 18K15971
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53040:Nephrology-related
Research InstitutionUniversity of Fukui

Principal Investigator

Daisuke Mikami  福井大学, 学術研究院医学系部門(附属病院部), 助教 (90464586)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords短鎖脂肪酸 / プロピオン酸 / GPR41 / GPR43 / 腸腎連関
Outline of Final Research Achievements

Propionic acid produced by intestinal microflora was administered to adenine-loaded mice. As a result, serum BUN and Cr levels were improved in a dose-dependent manner, and renal tissue was also improved. In addition, the effect of propionate on renal function was weaker in knockout mice with GPR41 and GPR43 receptors than in normal mice. Thus, the linkage between short-chain fatty acids, GPR41 and GPR43 was demonstrated. In addition, in the kidney tissue, inflammatory cytokines were significantly improved, indicating that GPR41 and GPR43 are involved in inflammation.

Academic Significance and Societal Importance of the Research Achievements

腸内細菌叢の改善が,腎保護効果につながる可能性を示すことが出来た.今後,慢性腎臓病(CKD)の治療の対象に腸内環境の調整,あるいは短鎖脂肪酸の投与が新たな治療法の一つになる可能性を考えた.

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (2 results)

All 2020 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Short-chain fatty acid mitigates adenine-induced chronic kidney disease via FFA2 and FFA3 pathways2020

    • Author(s)
      Mikami Daisuke、Kobayashi Mamiko、Uwada Junsuke、Yazawa Takashi、Kamiyama Kazuko、Nishimori Kazuhisa、Nishikawa Yudai、Nishikawa Sho、Yokoi Seiji、Kimura Hideki、Kimura Ikuo、Taniguchi Takanobu、Iwano Masayuki
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

      Volume: 1865 Issue: 6 Pages: 158666-158666

    • DOI

      10.1016/j.bbalip.2020.158666

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 慢性腎不全モデルマウスにおける短鎖脂肪酸の腎保護効果と分子機序の解明2018

    • Author(s)
      三上大輔
    • Organizer
      日本腎臓学会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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