| Project/Area Number |
18K15986
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53040:Nephrology-related
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
Okabe Masahiro 東京慈恵会医科大学, 医学部, 助教 (70595272)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ポドサイト / ポドサイト傷害 / 糸球体疾患 / EGR-1 / 慢性腎臓病 / ネフローゼ症候群 |
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| Outline of Final Research Achievements |
In human glomerular diseases, EGR-1 expression in podocytes was positively correlated with urinary protein level and urinary nephrin and podocin mRNA levels, and inversely correlated with glomerular podocin staining, suggesting that podocyte EGR-1 expression is associated with podocyte injury in humans as in mice. Also, EGR-1 expression in podocytes was positively correlated with acute lesions in histopathological findings, suggesting that EGR-1 expression reflects particularly acute injury. A subgroup analysis of IgA nephropathy in the same cohort showed similar results, and another analysis of lupus nephritis in a different cohort also showed an association between podocyte EGR1 expression and activity of the disease, consistent with previous reports. Therefore, podocyte EGR-1 expression may be a useful staining marker for podocyte injury.
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| Academic Significance and Societal Importance of the Research Achievements |
ヒトにおけるポドサイト傷害の染色マーカーは確立したものがなかったが，EGR-1がポドサイト傷害マーカーとして有用となるかもしれない．これにより，糸球体疾患でのポドサイト傷害の程度を可視化可能となる．また，ポドサイトのEGR-1発現率の違いにより，予後や治療反応性を予測し，免疫抑制剤の使用方法を変更するなど，オーダーメイド治療につながる可能性がある．
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