| Project/Area Number |
18K16039
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 自己免疫性疾患 / 汗腺 / 免疫学的特権 / 画像解析 / 免疫組織化学 / 皮膚科学 |
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| Outline of Final Research Achievements |
The pathogenesis of syringotropic autoimmune diseases remains elusive. In this study, the distribution of immune privilege (IP)-related molecules within sweat glands (SwG) in healthy and affected individuals were investigated by a quantitative immunohistochemical approach adopting digital image analysis. In the normal SwG, MHC class I expression was decreased, while macrophage migration inhibitory factor (MIF) and α melanocytic stimulating hormone (αMSH) was up-regulated in SwG. In Sjogren syndrome (SjS), lupus erythematosus (LE) and scleroderma (Scl), differential expression of these molecules were noted in SwG. CD200 expression decreased in atrophic stage of Scl. In human skin organ culture, intratissue injection of INF-γ, up-regulated MHC class I besides down-regulating MIF and αMSH. These findings demonstrated dysregulated expression patterns of individual IP-related molecules may account for their distinct inflammatory changes in syringotropic autoimmune disorders.
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| Academic Significance and Societal Importance of the Research Achievements |
汗腺を標的とする自己免疫性疾患の患者は、発汗障害による症状のため日常生活に支障を生じる場合がある。しかし、その病態は明らかではなく、確立した治療方法もないため、その病態解明は学術的、社会的に重要である。本研究は従来注目されていなかった免疫学的特権という観点から向汗腺性自己免疫応答の病態に迫った。本研究で得られた知見は、向汗腺性自己免疫性疾患の病態解明及び、治療開発の技術的基盤の一助になると考えた。
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