Elucidation between exposure to food antigens in indoor dust and the mechanism of food allergy development – a birth cohort study

• Project/Area Number: 18K16166
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 54020:Connective tissue disease and allergy-related
• Research Institution: National Center for Child Health and Development
• Principal Investigator: FUKUIE Tatsuki 国立研究開発法人国立成育医療研究センター, アレルギーセンター, 医長 (10535842)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: アレルゲン / 環境 / 感作 / 出生コホート / 食物アレルギー / アトピー性皮膚炎

Outline of Final Research Achievements

We investigated the effects of allergenic food concentrations in indoor environmental dust on the development of food allergies in participants in a high-risk birth cohort study. As a result, most bed mats used by 6-month-old babies contained allergens such as eggs, milk, and wheat that are likely to cause food allergies. In addition, it was confirmed that food and mite allergens adhered to clothes worn by babies for half a day, and the more frequently the mother ingested the foods, the more food allergens tended to be detected at the baby clothes. In this study, because of a cross-sectional study, the incidence of sensitization and food allergies was low in this 6-month of age, and the association was not significant. However, this study can be expected to produce high-level evidence by continuing to follow the clinical course in this birth cohort study.

Academic Significance and Societal Importance of the Research Achievements

本研究は「屋内塵埃中の食物抗原は乳児期における食物感作リスクとなる」という仮説を検証することである。鶏卵のみならず、複数のアレルゲンに対して出生コホート研究を用いて前向きに感作を検証したものは世界的にも無く、学術的意義がある。本仮説を証明することで、食物アレルギーの予防として経口摂取を控えることに傾倒しがちな臨床現場に新たなエビデンスを投じることができ、社会的な影響力がある。新規性について、「アレルギーマーチ」（乳児期のADやFAの後に吸入抗原が原因である喘息、鼻炎などが続いて発症する）の概念に、屋内塵埃中抗原が与える影響に関する考察を加えられる可能性があり、創造性がある。

Research Products

• [Journal Article] Effect of specific IgE on eliciting dose in children with cow's milk allergy. (2020)
  • Author(s): Fukuie T, Nishiura H, Miyaji Y, Matsumoto K, Ohya Y, Saito H.
  • Journal Title: J Allergy Clin Immunol Pract. Volume: 8 Issue: 10 Pages: 3660-3662
  • DOI: 10.1016/j.jaip.2020.06.059
  • Peer Reviewed
• [Journal Article] Japanese guidelines for food allergy 2020 (2020)
  • Author(s): Ebisawa Motohiro、Ito Komei、Fujisawa Takao、Aihara Yukoh、Ito Setsuko、Imai Takanori、Ohshima Yusei、et al
  • Journal Title: Allergology International Volume: 69 Issue: 3 Pages: 370-386
  • DOI: 10.1016/j.alit.2020.03.004
  • NAID: 130007877718
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Japanese guidelines for childhood asthma 2020 (2020)
  • Author(s): Arakawa H, Adachi Y, Ebisawa M, Fujisawa T; Committee for Japanese Pediatric Guideline for Childhood Asthma
  • Journal Title: Allergology International Volume: 69 Issue: 3 Pages: 314-330
  • DOI: 10.1016/j.alit.2020.02.005
  • NAID: 130007877696
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Pediatric patient with eosinophilic esophagitis and pollen-food allergy syndrome (2020)
  • Author(s): Irahara Makoto、Nomura Ichiro、Takeuchi Ichiro、Yamamoto-Hanada Kiwako、Shimizu Hirotaka、Fukuie Tatsuki、Yoshioka Takako、Arai Katsuhiro、Ohya Yukihiro
  • Journal Title: Asia Pacific Allergy Volume: 10 Issue: 3 Pages: e28-e28
  • DOI: 10.5415/apallergy.2020.10.e28
  • Peer Reviewed / Open Access
• [Journal Article] Impact of swimming school attendance in 3-year-old children with wheeze and rhinitis at age 5 years: A prospective birth cohort study in Tokyo (2020)
  • Author(s): Irahara Makoto、Yamamoto-Hanada Kiwako、Yang Limin、Saito-Abe Mayako、Sato Miori、Inuzuka Yusuke、Toyokuni Kenji、Nishimura Koji、Ishikawa Fumi、Miyaji Yumiko、Fukuie Tatsuki、Narita Masami、Ohya Yukihiro
  • Journal Title: PLOS ONE Volume: 15 Issue: 6 Pages: 0234161-0234161
  • DOI: 10.1371/journal.pone.0234161
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Consensus statements on pediatric atopic dermatitis from dermatology and pediatrics practitioners in Japan: Goals of treatment and topical therapy (2020)
  • Author(s): Arakawa Hirokazu、Shimojo Naoki、Katoh Norito、Hiraba Kazumi、Kawada Yasusuke、Yamanaka Keiichi、Igawa Ken、Murota Hiroyuki、Okafuji Ikuo、Fukuie Tatsuki、Nakahara Takeshi、Noguchi Taro、Kanakubo Akira、Katayama Ichiro
  • Journal Title: Allergology International Volume: 69 Issue: 1 Pages: 84-90
  • DOI: 10.1016/j.alit.2019.08.006
  • NAID: 130007788686
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Complementary and alternative medicine and atopic dermatitis in children (2020)
  • Author(s): Sato Miori、Yamamoto-Hanada Kiwako、Yang Limin、Irahara Makoto、Ishikawa Fumi、Iwama-Mitsui Motoko、Saito-Abe Mayako、Miyaji Yumiko、Inagaki Shinichiro、Fukuie Tatsuki、Nomura Ichiro、Narita Masami、Suzuki Kohta、Ohya Yukihiro
  • Journal Title: Journal of Dermatological Science Volume: 97 Issue: 1 Pages: 80-82
  • DOI: 10.1016/j.jdermsci.2019.11.011
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] IgE responses to multiple allergen components among school-aged children in a general population birth cohort in Tokyo (2020)
  • Author(s): Yamamoto-Hanada Kiwako、Borres Magnus P.、?berg Magnus K.、Yang Limin、Fukuie Tatsuki、Narita Masami、Saito Hirohisa、Ohya Yukihiro
  • Journal Title: World Allergy Organization Journal Volume: 13 Issue: 2 Pages: 100105-100105
  • DOI: 10.1016/j.waojou.2020.100105
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 経口免疫療法中に異食症により発見された好酸球性胃腸炎の1例 (2020)
  • Author(s): 西村 幸士, 福家 辰樹, 宮地 裕美子, 犬塚 祐介, 豊国 賢治, 苛原 誠, 石川 史, 佐藤 未織, 齋藤 麻耶子, 山本 貴和子, 成田 雅美, 野村 伊知郎, 大矢 幸弘
  • Journal Title: アレルギー Volume: 69 Pages: 123-128
  • NAID: 130007809353
  • Peer Reviewed
• [Journal Article] Four phenotypes of atopic dermatitis in Japanese children: A general population birth cohort study (2019)
  • Author(s): Yamamoto-Hanada Kiwako、Yang Limin、Saito-Abe Mayako、Sato Miori、Inuzuka Yusuke、Toyokuni Kenji、Nishimura Koji、Irahara Makoto、Ishikawa Fumi、Miyaji Yumiko、Fukuie Tatsuki、Narita Masami、Saito Hirohisa、Ohya Yukihiro
  • Journal Title: Allergology International Volume: 68 Issue: 4 Pages: 521-523
  • DOI: 10.1016/j.alit.2019.02.010
  • NAID: 130007733146
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] チペピジンヒベンズ酸塩(アスベリン錠)によるアナフィラキシーの1小児例 (2019)
  • Author(s): 小林 真也, 稲垣 真一郎, 福家 辰樹, 成田 雅美, 石黒 精, 大矢 幸弘
  • Journal Title: 日本小児臨床アレルギー学会誌 Volume: 17 Pages: 339-342
  • Peer Reviewed
• [Journal Article] クルミアレルギー診断におけるアレルゲンコンポーネントJug r 1特異的IgE抗体測定の有用性 (2019)
  • Author(s): 佐藤 さくら, 福家 辰樹, 伊藤 浩明, 今井 孝成, 近藤 康人, 北林 耐, 長尾 みづほ, 増本 夏子, 海老澤 元宏
  • Journal Title: 日本小児アレルギー学会誌 Volume: 33 Pages: 692-701
  • NAID: 130007777968
  • Peer Reviewed
• [Journal Article] Palmar hyperlinearity in early childhood atopic dermatitis is associated with filaggrin mutation and sensitization to egg (2019)
  • Author(s): Fukuie Tatsuki、Yasuoka Ryuhei、Fujiyama Toshiharu、Sakabe Jun‐ichi、Taguchi Tomohide、Tokura Yoshiki
  • Journal Title: Pediatric Dermatology Volume: 36 Issue: 2 Pages: 213-218
  • DOI: 10.1111/pde.13752
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 食物経口負荷試験の実際 プライマリケアから専門病院まで (2020)
  • Author(s): 福家辰樹
  • Organizer: 第123回日本小児科学会モーニング実践講座
  • Invited
• [Presentation] アレルギー疾患の発症予防-アトピー性皮膚炎への介入. (2020)
  • Author(s): 福家辰樹
  • Organizer: JSA/WAO joint congress. 2020
  • Int'l Joint Research / Invited
• [Presentation] 小児アレルギー疾患・診断の最前線. 湿疹への介入はいつから (2020)
  • Author(s): 福家辰樹
  • Organizer: 第57回日本小児アレルギー学会シンポジウム3
  • Invited
• [Presentation] 食物アレルギー管理の最新情報. (2020)
  • Author(s): 福家辰樹
  • Organizer: 第57回日本小児アレルギー学会シンポジウム3
  • Invited
• [Presentation] Effect of the specific IgE level on the eliciting dose in patients with cow’s milk allergy evaluated by a positive oral food challenge. (2019)
  • Author(s): Fukuie T, Miyaji Y, Inuzuka Y, Toyokuni K, Nishimura K, Ishikawa F, Irahara M, Sato S, Saito-Abe M, Yamamoto-Hanada K, Narita M, Matsumoto K, Ohya Y, and Saito H.
  • Organizer: EAACI 2019 Congress. Lisbon, Portugal. 2019.6.4
  • Int'l Joint Research
• [Presentation] Shorter time interval during oral food challenge may overlook the real threshold dose. (2019)
  • Author(s): Fukuie T, Miyaji Y, Ishikawa F, Irahara M, Iwama M, Sato S, Saito M, Inagaki S, Yamamoto-Hanada K, Narita M, Matsumoto K, Ohya Y, and Saito H.
  • Organizer: American Academy of Allergy and Immunology Annual Meeting, 2019, San Francisco, USA, 2019.2.24.
  • Int'l Joint Research
• [Presentation] 食物経口負荷試験 (2019)
  • Author(s): 福家辰樹
  • Organizer: 第2回日本アレルギー学会関東地方会
  • Invited
• [Presentation] アトピー性皮膚炎のプロアクティブ療法 (2019)
  • Author(s): 福家辰樹
  • Organizer: 第112回東京小児科医会学術講演会
  • Invited
• [Presentation] アトピー性皮膚炎の発症予防 -臨床研究によりどこまで分かったのか (2019)
  • Author(s): 福家辰樹
  • Organizer: 第56回日本小児アレルギー学会学術大会
  • Invited
• [Presentation] Year in review アトピー性皮膚炎 (2019)
  • Author(s): 福家辰樹
  • Organizer: 第56回日本小児アレルギー学会学術大会
  • Invited
• [Presentation] アトピー性皮膚炎の発症と予防 (2019)
  • Author(s): 福家辰樹
  • Organizer: 第49回日本皮膚免疫アレルギー学会総会学術大会
  • Invited
• [Presentation] Sensitization to dust mite is associated with an increased risk of high FeNO levels and future onset of asthma: a population-based birth cohort study. (2018)
  • Author(s): Fukuie T, Narita M, Yamamoto-Hanada K, Ishikawa F, Irahara M, Mitsui M, Sato S, Miyaji Y, Inagaki S, Saito M, Yang L, Saito H, and Ohya Y.
  • Organizer: EAACI 2018, Munich, Germany
  • Int'l Joint Research
• [Book] アレルギー診療に携わる医療者のための 小児アレルギー疾患免疫療法 A to Z (2020)
  • Author(s): 勝沼俊雄
  • Total Pages: 184
  • Publisher: 日本医事新報社
  • ISBN: 9784784933822
• [Book] WHAT'S NEW in 皮膚科学 2020-2021 (2020)
  • Author(s): 宮地良樹、常深祐一郎、鶴田大輔
  • Total Pages: 238
  • Publisher: メディカルレビュー社
  • ISBN: 9784779222689
• [Book] 小児疾患の薬物治療 ガイドライン総まとめ (2020)
  • Author(s): 五十嵐 隆
  • Total Pages: 288
  • Publisher: 株式会社じほう
• [Book] 学校保健の動向 令和2年度版 (2020)
  • Author(s): 小出 彰宏
  • Total Pages: 250
  • Publisher: 日本学校保健会
  • ISBN: 9784903076249
• [Book] 食物アレルギーの栄養指導第2版（海老澤元宏監修） ５．予知と予防 (2018)
  • Author(s): 福家 辰樹
  • Total Pages: 4
  • Publisher: 医歯薬出版