• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The mechanism of the effect of Alzheimer's disease on the systemic glucose metabolism

Research Project

Project/Area Number 18K16190
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 54040:Metabolism and endocrinology-related
Research InstitutionTohoku University

Principal Investigator

Asai Yoichiro  東北大学, 大学病院, 助教 (50754925)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords糖尿病 / アルツハイマー型認知症 / インスリン抵抗性 / 認知症 / 臓器連関
Outline of Final Research Achievements

The effects of sporadic Alzheimer's disease on systemic glucose metabolism were investigated. The intra-cerebroventricular injection of streptozotocin(STZ) caused wild type mice cognitive dysfunction. The inflammation with the increase of microglia was observed in the areas of hippocampus and entorhinal cortex of STZ-icv mice. Furthermore, STZ-icv mice exhibited hyper-insulinemia and insulin resistance. The expression levels of insulin signal-related genes were different between the liver and the skeletal muscles.
These results suggest the possibility that Alzheimer's disease itself may bring systemic insulin resistance.

Academic Significance and Societal Importance of the Research Achievements

これまで、糖尿病やインスリン抵抗性がアルツハイマー型認知症の発症を促進する機序について数多くの研究が報告されている一方で、アルツハイマー型認知症自体が糖代謝に与える影響についての報告はほとんどない。本研究は、アルツハイマー型認知症が糖尿病・インスリン抵抗性を悪化させ、さらに認知症を促進させるという悪循環を来しうる可能性を示唆しており、認知症と糖代謝異常の進行を予防する為の基盤の知見となる事が考えられる。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2019 2018

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Book (1 results)

  • [Journal Article] Enhancement of postprandial endogenous insulin secretion rather than exogenous insulin injection ameliorated insulin antibody-induced unstable diabetes: a case report2019

    • Author(s)
      Kaneko K, Satake C, Izumi T, Tanaka M, Yamamoto J, Asai Y, Sawada S, Imai J, Yamada T, Katagiri H.
    • Journal Title

      BMC Endocr Disord.

      Volume: 19 Issue: 1 Pages: 5-5

    • DOI

      10.1186/s12902-018-0326-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation2018

    • Author(s)
      Izumi T, Imai J, Yamamoto J, Kawana Y, Endo A, Sugawara H, Kohata M, Asai Y, Takahashi K, Kodama S, Kaneko K, Gao J, Uno K, Sawada S, Kalinichenko VV, Ishigaki Y, Yamada T, Katagiri H.
    • Journal Title

      Nat Commun.

      Volume: 9 Issue: 1 Pages: 5300-5300

    • DOI

      10.1038/s41467-018-07747-0

    • URL

      https://pure.teikyo.jp/en/publications/17e764e4-9686-40fb-84e9-eea24f5c6af2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Book] 決定版 阻害剤・活性化剤ハンドブック2019

    • Author(s)
      浅井洋一郎, 片桐秀樹
    • Total Pages
      13
    • Publisher
      羊土社
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi