| Project/Area Number |
18K16396
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55030:Cardiovascular surgery-related
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| Research Institution | Ehime University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 大動脈弁狭窄症 / 石灰化 / 生体弁 / 骨芽細胞 / 膠原線維 / 心膜癒着組織 / 弁間質細胞 / 再生医療 / 間質細胞 / AS / マクロファージ / 弁膜症 |
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| Outline of Final Research Achievements |
The molecular mechanism of aortic valve stenosis remains unknown. Calcified aortic valves are replaced with porcine or bovine pericardium-derived bioprosthetic valves. However, the implanted bioprosthetic valves are occasionally explanted due to structural valve degeneration. In the current study, we focused on molecular mechanism underlying calcification of native and bioprosthetic valves. Comprehensive mRNA and protein expression analyses discovered oxidative stress-related proteins and glycoproteins as the master regulators of calcification. Additionally, we also found that collagen digestion might prime calcification of bioprosthetic valves. Taken together, our results contribute to the establishment of anti-deterioration therapy for valve calcification.
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| Academic Significance and Societal Importance of the Research Achievements |
大動脈弁組織において石灰化が起こる分子機構は未だに不明である。我々が実施している臨床検体を開始点としたトランスレーショナル研究は、ASの新規治療法の開発に繋がる。特に本研究で見出した石灰化関連分子はAS治療の新しい標的となる可能性があり、今後の研究が期待される。また、一方で今回新たに見出した生体弁劣化機構に関する研究成果は、今後劣化しない耐久性のある生体弁の開発に繋げることができる。
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