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The role of TRPV4 channel in on Ventilator- induced lung injury in Septic rats

Research Project

Project/Area Number 18K16464
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 55050:Anesthesiology-related
Research InstitutionSuzuka University of Medical Science

Principal Investigator

Kawai Masako  鈴鹿医療科学大学, 医用工学部, 助教 (80460640)

Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords敗血症 / 人工呼吸誘発肺障害VILI / TRPV4 / 人工呼吸誘発肺障害 VILI / Sepsis / VILI / 人工呼吸 / 人工呼吸誘発肺障害
Outline of Final Research Achievements

The pathogenesis of mechanical ventilation-induced lung injury (VILI) is thought to be caused by damage to the alveolar epithelium via local alveolar hyperinflation and release of inflammatory mediators. The detailed mechanism, however, has not been clarified yet. In this study, we have confirmed that mRNA expression and protein levels of inflammatory cytokines (IL-6, IL-10) and chemokines (CXCL1, CXCL2, CCL2) were suppressed by inhibiting TRPV4 channels using its inhibitor (HC-067047) in experimental sepsis model in rats. This will make a certain contribution to elucidating the mechanism of VILI, and suggests that clarifying the role of TRPV4 in sepsis is academically and medically important.

Academic Significance and Societal Importance of the Research Achievements

人工呼吸誘発肺障害(VILI)の発生機序は、局所的な肺胞の過膨張による損傷が原因とされ、肺胞上皮の損傷や、それらによって放出されるメディエータによる障害も考えられているが、はっきりとした要因は明らかになっていない。本研究では、敗血症ラットモデルにおいて、圧刺激で活性化する TRPV4 チャネルを阻害することにより、炎症性サイトカイン・ケモカインが低下することを確認できた。これは、VILI のメカニズム解明に一定の寄与をするものであり、敗血症における TRPV4 の役割について明らかにすることが、学術的にも医学的にも必要であるとの示唆を与える。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (2 results)

All 2022 2021

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results)

  • [Journal Article] Lung damage created by high tidal volume ventilation in rats with monocrotaline-induced pulmonary hypertension2022

    • Author(s)
      Masako Kawai 1 2 , Erquan Zhang 1 3 , Jane Chanda Kabwe , Amphone Okada , Junko Maruyama , Hirofumi Sawada , Kazuo Maruyama
    • Journal Title

      BMC Pulmonary Medicine

      Volume: 78 Issue: 1 Pages: 1-13

    • DOI

      10.1186/s12890-022-01867-6

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Model difference in the effect of cilostazol on the development of experimental pulmonary hypertension in rats2021

    • Author(s)
      Ito T、Zhang E、Omori A、Kabwe J、Kawai M、Maruyama J、Okada A、Yokochi A、Sawada H、Mitani Y、Maruyama K
    • Journal Title

      BMC Pulmonary Medicine

      Volume: 21 Issue: 1 Pages: 377-377

    • DOI

      10.1186/s12890-021-01710-4

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access

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Published: 2018-04-23   Modified: 2025-01-30  

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