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Development of novel treatment of ischemic stroke via pentraxin 3

Research Project

Project/Area Number 18K16557
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56010:Neurosurgery-related
Research InstitutionMie University

Principal Investigator

Shindo Akihiro  三重大学, 医学部附属病院, 准教授 (60422820)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords脳梗塞 / 白質 / ペントラキシン3 / 血液脳関門 / グリア / 血管新生 / Pentraxin 3 / Astrocyte / Stroke / White matter / pentraxin 3 / astrocyte / neural stem cell / endothelial cell / glia / oligodendrocyte / 脳卒中 / 炎症
Outline of Final Research Achievements

Bi-phasic and cell-type dependent roles of pentraxin 3 after cerebral white matter injury: Accumulating evidence now suggest that deleterious factors in acute brain injury may in turn contribute to brain remodeling in the recovery phase. Pentraxin 3 (PTX3), which is known to be upregulated after stroke, supports blood-brain barrier integrity under pathological conditions. However, one of the role of PTX3 might suppress the angiogenesis in recovery phase of ischemic stroke. In this study, we examined the hypothesis that PTX3 may have important roles after ischemic stroke in both acute and sub-acute phase, mediate crosstalk between reactive astrocytes and other types of cells. PTX3 may possess differential effects on compensatory angiogenesis, neurogenesis, and oligodendrogenesis. Our findings would give a novel insight in developing therapies to support stroke recovery.

Academic Significance and Societal Importance of the Research Achievements

虚血性脳卒中の新たな治療法開発は高齢化社会を迎えている本邦において重要なテーマである。ペントラキシン3は血管内皮由来の炎症性タンパク質として知られるが、同時に血液脳関門保護、一方で血管新生の抑制に働くことが示され、オリゴデンドロサイト前駆細胞の分化抑制といった効果の存在が示唆された。現在血栓回収療法などにより脳血管障害の予後改善が得られているが、追加治療の存在によりさらなる治療成績の向上につながる可能性がある。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (7 results)

All 2020 2019

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 4 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Clinical Features and Experimental Models of Cerebral Small Vessel Disease2020

    • Author(s)
      Shindo Akihiro、Ishikawa Hidehiro、Ii Yuichiro、Niwa Atsushi、Tomimoto Hidekazu
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 12 Pages: 109-109

    • DOI

      10.3389/fnagi.2020.00109

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reversible splenial lesion in a patient with new-onset refractory status epilepticus (NORSE)2020

    • Author(s)
      Mizutani Akane Unno、Shindo Akihiro、Arikawa Shigeo、Shimada Takuya、Matsuura Keita、Ikejiri Kaoru、Suzuki Kei、Imai Hiroshi、Tomimoto Hidekazu
    • Journal Title

      eNeurologicalSci

      Volume: 18 Pages: 100220-100220

    • DOI

      10.1016/j.ensci.2019.100220

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chronic cerebral hypoperfusion activates AIM2 and NLRP3 inflammasome2020

    • Author(s)
      Matsuyama Hirofumi、Shindo Akihiro、Shimada Takuya、Yata Kenichiro、Wakita Hideaki、Takahashi Ryosuke、Tomimoto Hidekazu
    • Journal Title

      Brain Research

      Volume: 1736 Pages: 146779-146779

    • DOI

      10.1016/j.brainres.2020.146779

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chronic cerebral hypoperfusion upregulates leptin receptor expression in astrocytes and tau phosphorylation in tau transgenic mice.2019

    • Author(s)
      Shimada T, Shindo A, Matsuyama H, Yata K, Niwa A, Sasaki R, Ayaki T, Maki T, Wakita H, Tomimoto H.
    • Journal Title

      Neuroscience Letters

      Volume: 704 Pages: 133-140

    • DOI

      10.1016/j.neulet.2019.04.009

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microbleeds after Carotid Artery Stenting: Small Embolism May Induce Cerebral Microbleeds2019

    • Author(s)
      Ogawa Ito Ai、Shindo Akihiro、Ii Yuichiro、Matsuura Keita、Tabei Ken-ichi、Maeda Masayuki、Umino Maki、Suzuki Yume、Shiba Masato、Toma Naoki、Suzuki Hidenori、Tomimoto Hidekazu
    • Journal Title

      Cerebrovascular Diseases Extra

      Volume: 9 Issue: 2 Pages: 57-65

    • DOI

      10.1159/000500112

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Small Cortical Infarcts Transformed to Lobar Cerebral Microbleeds: A Case Series2019

    • Author(s)
      Ito Ai Ogawa、Shindo Akihiro、Ii Yuichiro、Ishikawa Hidehiro、Taniguchi Akira、Shiba Masato、Toma Naoki、Suzuki Hidenori、Tomimoto Hidekazu
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 28 Issue: 4 Pages: e30-e32

    • DOI

      10.1016/j.jstrokecerebrovasdis.2018.12.050

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Cerebral Venous Thrombosis Caused by Congenital Thrombophilia in Japan2020

    • Author(s)
      Akihiro Shindo
    • Organizer
      International Stroke Conference 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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