Does indirect bypass surgery combined with high mobility group box-1 administration improve cerebral perfusion in a chronic cerebral hypoperfusion model?
Project/Area Number |
18K16585
|
Research Category |
Grant-in-Aid for Early-Career Scientists
|
Allocation Type | Multi-year Fund |
Review Section |
Basic Section 56010:Neurosurgery-related
|
Research Institution | Okayama University |
Principal Investigator |
|
Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 慢性脳虚血モデル / 間接血行再建術 / HMGB1蛋白 / VEGF / 血管新生 / 慢性脳虚血 / 間接バイパス術 / HMGB1 / もやもや病 / 脳血流SPECT |
Outline of Final Research Achievements |
Moyamoya disease is an intractable disease in which cerebral blood flow is reduced due to progressive stenosis and occlusion of bilateral internal carotid arteries, resulting in cerebral infarction. One of the treatment methods is indirect revascularization, in which muscles are placed on the brain's surface to increase cerebral blood flow. We have focused on HMGB1 protein, an angiogenic factor, as drug therapy to increase cerebral blood flow further. In the experiment, we occluded bilateral common carotid arteries of rats to reduce cerebral blood flow. We laid the unilateral temporal muscle on the brain surface to create a moyamoya disease surgical model. Furthermore, by administering HMGB1 protein to the temporal muscle used in the surgery, we were able to increase the number of blood vessels in the cerebral cortex and show that cerebral blood flow increased compared to when HMGB1 protein was not administered.
|
Academic Significance and Societal Importance of the Research Achievements |
もやもや病手術モデルにおける薬物療法は、今までに報告されてきたものは遺伝子を用いたものだけでしたが、今回は蛋白製剤(HMGB1蛋白)を用いることで脳表の血管が増加していることを示すことができ、さらに脳血流評価によってその有効性を示すことができた点が、学術的意義があると考えられる点です。この結果により、もやもや病の間接血行再建術における薬物併用療法が、より臨床応用しやすくなったため、社会的意義があったと考えられます。
|
Report
(4 results)
Research Products
(155 results)
-
[Journal Article] Osseous arteriovenous fistulas in the dorsum sellae, clivus, and condyle2021
Author(s)
Hiramatsu M, Sugiu K, Haruma J, Hishikawa T, Takahashi Y, Murai S, Nishi K, Yamaoka Y, Date I
-
Journal Title
Neuroradiology
Volume: 63(1)
Issue: 1
Pages: 133-140
DOI
Related Report
Peer Reviewed
-
[Journal Article] 脳出血2021
Author(s)
平松匡文、春間 純、菱川朋人、杉生憲志、伊達 勲
-
Journal Title
脳神経外科
Volume: 49(2)
Pages: 284-292
Related Report
Peer Reviewed
-
[Journal Article] Metal artifact reduction algorithm for image quality improvement of cone-beam CT images of medium or large cerebral aneurysms treated with stent-assisted coil embolization2020
Author(s)
Murai S, Hiramatsu M, Takasugi Y, Takahashi Y, Kidani N, Nishihiro S, Shinji Y, Haruma J, Hishikawa T, Sugiu K, Date I
-
Journal Title
Neuroradiology
Volume: 62(1)
Issue: 1
Pages: 89-96
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Detailed arterial anatomy and its anatomoses of the sphenoid ridge and olfactory groove meningiomas with special reference to the recurrent branches from the ophthalmic artery2020
Author(s)
Hiramatsu M , Sugiu K , Hishikawa T , Haruma J , Takahashi Y , Murai S , Nishi K , Yamaoka Y , Shimazu Y , Fujii K , Kameda M , Kurozumi K , Date I
-
Journal Title
AJNR Americal Journal of Neuroradiology
Volume: 41(11)
Issue: 11
Pages: 2082-2087
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Journal Article] High-mobility group box-1-induced angiogenesis after indirect bypass surgery in a chronic cerebral hypoperfusion model2019
Author(s)
Nishihiro S , Hishikawa T , Hiramatsu M , Kidani N , Takahashi Y , Murai S , Sugiu K , Higaki Y , Yasuhara T , Borlongan CV , Date I
-
Journal Title
Neuromoloecular Medicine
Volume: 21
Issue: 4
Pages: 391-400
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] A comparison of the prevalence and risk factors of complications in intracranial tumor embolization between the Japanese Registry of NeuroEndovascular Therapy 2 (JR-NET and JR-NET32019
Author(s)
Hishikawa T , Sugiu K , Murai S , Takahashi Y , Kidani N , Nishihiro S , Hiramatsu M , Date I , Satow T , Iihara K , Sakai N , JR-NET2 and JR-NET 3 study groups
-
Journal Title
Acta Neurochirurgica (Wien)
Volume: 161
Issue: 8
Pages: 1675-1682
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Results of 1940 embolizations for dural arteriovenous fistulas: Japanese Registry of Neuroendovascular Therapy (JR-NET3)2019
Author(s)
Hiramatsu M , Sugiu K , Hishikawa T , Nishihiro S , Kidani N , Takahashi Y , Murai S , Date I , Kuwayama N , Satow T , Iihara K , Sakai N
-
Journal Title
Journal of Neurosurgery Therapy
Volume: ー
Issue: 1
Pages: 166-173
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Treatment Outcome of Intracranial Tumor Embolization in Japan: Japanese Registry of NeuroEndovascular Therapy 3 (JR-NET3)2019
Author(s)
Sugiu K , Hishikawa T , Murai S , Takahashi Y , Kidani N , Nishihiro S , Hiramatsu M , Date I , Satow T , Iihara K , Sakai N
-
Journal Title
Neurologia medico-chirurgica
Volume: 59
Issue: 2
Pages: 41-47
DOI
NAID
ISSN
0470-8105, 1349-8029
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
[Journal Article] NADH fluorescence imaging and the histological impact of cortical spreading depolarization during the acute phase of subarachnoid hemorrhage in rats2017
Author(s)
Shimizu T , Hishikawa T , Nishihiro S , Shinji Y , Takasugi Y , Haruma J , Hiramatsu M , Kawase H , Sato S , Mizoue R , Takeda Y , Sugiu K , Morimatsu H , Date I
-
Journal Title
Journal of Neurosurgery
Volume: 印刷中
Issue: 1
Pages: 137-143
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-