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Evaluation of the relationship between chronic psychological stress and intracranial aneurysm formation / rupture

Research Project

Project/Area Number 18K16599
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56010:Neurosurgery-related
Research InstitutionJikei University School of Medicine (2019-2021)
Tokyo Women's Medical University (2018)

Principal Investigator

Koseki Hirokazu  東京慈恵会医科大学, 医学部, 助教 (10766546)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Keywords脳動脈瘤 / ストレス / 慢性的精神ストレス / 慢性炎症 / 血流ストレス / くも膜下出血 / 慢性ストレス / 脳血管障害 / SITH-1 / CFD / 精神的ストレス / 脳血管疾患
Outline of Final Research Achievements

Intracranial aneurysms are usually asymptomatic. However, they cause subarachnoid hemorrhage when they rupture. To avoid such a devastating episode, it is extremely important to identify and deal with the risk of rupture. Focusing on the relationship between mental stress and illness, I researched the effects on the development and rupture of intracranial aneurysms. As a result, no relationship between intracranial aneurysms and mental stress was found in any of the studies using animal model and clinical studies targeting patients. On the other hand, it was suggested that there is a sex difference in the accumulation of mental stress for the same one.

Academic Significance and Societal Importance of the Research Achievements

従来より慢性的精神ストレスと疾病の関係が示唆されているが、同一ストレッサーに対するストレスの蓄積には個人差があるのみならず、慢性ストレスをターゲットとしたマーカー因子は確立されていない。本研究では、脳動脈瘤の未知のリスク因子探求の一環として慢性的精神ストレスの評価を試み、その関連性を明らかにした。結果としてその関連性は見出せなかったが、脳血管疾患と慢性的精神ストレスについて検討した初の試みであった。このノウハウを生かして、他の疾患においても検討していきたい。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (23 results)

All 2021 2020 2019 2018 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results,  Open Access: 7 results) Presentation (7 results) (of which Int'l Joint Research: 5 results) Book (1 results) Remarks (3 results)

  • [Journal Article] 総説 実験的脳動脈瘤モデルを用いた基礎研究の歴史と最新知見2021

    • Author(s)
      小関 宏和、村山 雄一
    • Journal Title

      Neurological Surgery 脳神経外科

      Volume: 49 Issue: 4 Pages: 888-897

    • DOI

      10.11477/mf.1436204467

    • ISSN
      0301-2603, 1882-1251
    • Year and Date
      2021-07-10
    • Related Report
      2021 Annual Research Report
  • [Journal Article] Computational fluid dynamic analysis of the initiation of cerebral aneurysms2021

    • Author(s)
      Fujimura Soichiro、Tanaka Kazutoshi、Takao Hiroyuki、Okudaira Takuma、Koseki Hirokazu、Hasebe Akiko、Suzuki Takashi、Uchiyama Yuya、Ishibashi Toshihiro、Otani Katharina、Karagiozov Kostadin、Fukudome Koji、Hayakawa Motoharu、Yamamoto Makoto、Murayama Yuichi
    • Journal Title

      Journal of Neurosurgery

      Volume: Dec 21. Issue: 2 Pages: 1-9

    • DOI

      10.3171/2021.8.jns211452

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hemodynamic Force as a Potential Regulator of Inflammation-Mediated Focal Growth of Saccular Aneurysms in a Rat Model2020

    • Author(s)
      Shimizu Kampei、Kataoka Hiroharu、Imai Hirohiko、Yamamoto Yuto、Yamada Tomohiro、Miyata Haruka、Koseki Hirokazu、Abekura Yu、Oka Mieko、Kushamae Mika、Ono Isao、Miyamoto Susumu、Nakamura Masanori、Aoki Tomohiro
    • Journal Title

      Journal of Neuropathology & Experimental Neurology

      Volume: 80 Issue: 1 Pages: 79-88

    • DOI

      10.1093/jnen/nlaa131

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eicosapentaenoic acid prevents the progression of intracranial aneurysms in rats2020

    • Author(s)
      Abekura Yu、Ono Isao、Kawashima Akitsugu、Takizawa Katsumi、Koseki Hirokazu、Miyata Haruka、Shimizu Kampei、Oka Mieko、Kushamae Mika、Miyamoto Susumu、Kataoka Hiroharu、Ishii Akira、Aoki Tomohiro
    • Journal Title

      Journal of Neuroinflammation

      Volume: 17 Issue: 1 Pages: 129-129

    • DOI

      10.1186/s12974-020-01802-8

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dedifferentiation of smooth muscle cells in intracranial aneurysms and its potential contribution to the pathogenesis2020

    • Author(s)
      Oka M, Shimo S, Ohno N, Imai H, Abekura Y, Koseki H, Miyata H, Shimizu K, Kushamae M, Ono I, Nozaki K, Kawashima A, Kawamata T, Aoki T
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 8330-8330

    • DOI

      10.1038/s41598-020-65361-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of neutrophils in machineries underlying the rupture of intracranial aneurysms2020

    • Author(s)
      Kushamae M, Miyata H, Shirai M, Shimizu K, Oka M, Koseki H, Abekura Y, Ono I, Nozaki K, Mizutani T, Aoki T
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 20004-20004

    • DOI

      10.1038/s41598-020-74594-9

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] RNA sequencing analysis revealed the induction of CCL3 expression in human intracranial aneurysms2019

    • Author(s)
      Aoki Tomohiro、Koseki Hirokazu、Miyata Haruka、Itoh Masayoshi、Kawaji Hideya、Takizawa Katsumi、Kawashima Akitsugu、Ujiie Hiroshi、Higa Takashi、Minamimura Kenzo、Kimura Toshikazu、Kasuya Hidetoshi、Nozaki Kazuhiko、Morita Akio、Sano Hirotoshi、Narumiya Shuh
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 10387-10387

    • DOI

      10.1038/s41598-019-46886-2

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vasa vasorum formation is associated with rupture of intracranial aneurysms2019

    • Author(s)
      Miyata Haruka、Imai Hirohiko、Koseki Hirokazu、Shimizu Kampei、Abekura Yu、Oka Mieko、Kawamata Takakazu、Matsuda Tetsuya、Nozaki Kazuhiko、Narumiya Shuh、Aoki Tomohiro
    • Journal Title

      Journal of Neurosurgery

      Volume: ePub Issue: 3 Pages: 1-11

    • DOI

      10.3171/2019.5.jns19405

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rat Model of Intracranial Aneurysm: Variations, Usefulness, and Limitations of the?Hashimoto Model2019

    • Author(s)
      Aoki Tomohiro、Miyata Haruka、Abekura Yu、Koseki Hirokazu、Shimizu Kampei
    • Journal Title

      Acta Neurochirurgica Supplement

      Volume: 127 Pages: 35-41

    • DOI

      10.1007/978-3-030-04615-6_6

    • ISBN
      9783030046149, 9783030046156
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Two Diverse Hemodynamic Forces, a Mechanical Stretch and a High Wall Shear Stress, Determine Intracranial Aneurysm Formation.2019

    • Author(s)
      Koseki H, Miyata H, Shimo S, Ohno N, Mifune K, Shimano K, Yamamoto K, Nozaki K, Kasuya H, Narumiya S, Aoki T.
    • Journal Title

      Transl Stroke Res.

      Volume: Epub ahead of print Issue: 1 Pages: 1-13

    • DOI

      10.1007/s12975-019-0690-y

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Real-time Imaging of an Experimental Intracranial Aneurysm in Rats2019

    • Author(s)
      MIYATA Haruka、SHIMIZU Kampei、KOSEKI Hirokazu、ABEKURA Yu、KATAOKA Hiroharu、MIYAMOTO Susumu、NOZAKI Kazuhiko、NARUMIYA Shuh、AOKI Tomohiro
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 59 Issue: 1 Pages: 19-26

    • DOI

      10.2176/nmc.oa.2018-0197

    • NAID

      130007579712

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 総説 炎症を通し脳動脈瘤を理解する2018

    • Author(s)
      青木 友浩、小関 宏和、宮田 悠、安部倉 友、清水 寛平
    • Journal Title

      Neurological Surgery 脳神経外科

      Volume: 46 Issue: 4 Pages: 275-294

    • DOI

      10.11477/mf.1436203718

    • ISSN
      0301-2603, 1882-1251
    • Year and Date
      2018-04-10
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 実験的動物モデルにおける動脈瘤発生に対するCFD解析の研究2021

    • Author(s)
      葛西 智基、小関 宏和、高尾 洋之、加藤 直樹、菅 一成、藤村 宗一郎、内山 祐也、山中 悠真、石橋 敏寛、福留 功二、山本 誠、村山 雄一
    • Organizer
      第37回日本脳血管内治療学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Computational Fluid Dynamics Simulation of Aneurysm Initiation in Experimental Animal Models2021

    • Author(s)
      Kasai Tomoki, Koseki Hirokazu, Takao Hiroyuki, Fujimura Soichiro, Kato Naoki, Kan Issei, Uchiyama Yuya, Yamanaka Yuma, Ishibashi Toshihiro, Fukudome Kouji, Murayama Yuichi, Yamamoto Makoto
    • Organizer
      The 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A high wall shear stress and a mechanical stretch cooperatively regulate intracranial aneurysm formation.2019

    • Author(s)
      Koseki H, Kasuya H, Aoki T
    • Organizer
      International Subarachnoid Hemorrhage Conference 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脳動脈瘤初期形成過程を規定するwall shear stress以外の血行力学的因子ー伸展張力の重要性ー2019

    • Author(s)
      小関宏和、宮田悠、野崎和彦、糟谷英俊、村山雄一、青木友浩
    • Organizer
      第78回日本脳神経外科学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Usefulness of animal model for translational research of intracranial aneurysm.2019

    • Author(s)
      Koseki Hirokazu and Kasuya Hidetoshi
    • Organizer
      6th Tokyo-Shanghai Friendship Neurosurgical Forum
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Utility of animal model and translational research for intracranial aneurysms2018

    • Author(s)
      Koseki Hirokazu, Aoki Tomohiro and Kasuya Hidetoshi
    • Organizer
      2nd China-Japan Cerebrovascular Disease Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Two distinct mechanical force, high wall shear stress and mechanical stretch, regulate intracranial aneurysm formation2018

    • Author(s)
      Koseki Hirokazu, Miyata Haruka and Aoki Tomohiro
    • Organizer
      Intracranial Aneurysm Workshop 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Book] 完全版 脳血管内治療学2018

    • Author(s)
      滝 和郎、宮地 茂、松丸 祐司、田中 美千裕
    • Total Pages
      512
    • Publisher
      メディカ出版
    • ISBN
      9784840464895
    • Related Report
      2018 Research-status Report
  • [Remarks] Research map

    • URL

      https://researchmap.jp/hk-ns-19

    • Related Report
      2021 Annual Research Report
  • [Remarks] Research Gate

    • URL

      https://www.researchgate.net/profile/Hirokazu-Koseki

    • Related Report
      2021 Annual Research Report
  • [Remarks] 東京慈恵会医科大学研究業績閲覧サイト

    • URL

      http://www.jikei.ac.jp/academic/research_achievements/

    • Related Report
      2021 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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