Evaluation of the relationship between chronic psychological stress and intracranial aneurysm formation / rupture
| Project/Area Number |
18K16599
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56010:Neurosurgery-related
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| Research Institution | Jikei University School of Medicine (2019-2021)
Tokyo Women's Medical University (2018) |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
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| Keywords | 脳動脈瘤 / ストレス / 慢性的精神ストレス / 慢性炎症 / 血流ストレス / くも膜下出血 / 慢性ストレス / 脳血管障害 / SITH-1 / CFD / 精神的ストレス / 脳血管疾患 |
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| Outline of Final Research Achievements |
Intracranial aneurysms are usually asymptomatic. However, they cause subarachnoid hemorrhage when they rupture. To avoid such a devastating episode, it is extremely important to identify and deal with the risk of rupture. Focusing on the relationship between mental stress and illness, I researched the effects on the development and rupture of intracranial aneurysms. As a result, no relationship between intracranial aneurysms and mental stress was found in any of the studies using animal model and clinical studies targeting patients. On the other hand, it was suggested that there is a sex difference in the accumulation of mental stress for the same one.
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| Academic Significance and Societal Importance of the Research Achievements |
従来より慢性的精神ストレスと疾病の関係が示唆されているが、同一ストレッサーに対するストレスの蓄積には個人差があるのみならず、慢性ストレスをターゲットとしたマーカー因子は確立されていない。本研究では、脳動脈瘤の未知のリスク因子探求の一環として慢性的精神ストレスの評価を試み、その関連性を明らかにした。結果としてその関連性は見出せなかったが、脳血管疾患と慢性的精神ストレスについて検討した初の試みであった。このノウハウを生かして、他の疾患においても検討していきたい。
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Report
(5 results)
Research Products
(23 results)
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[Journal Article] Dedifferentiation of smooth muscle cells in intracranial aneurysms and its potential contribution to the pathogenesis2020
Author(s)
Oka M, Shimo S, Ohno N, Imai H, Abekura Y, Koseki H, Miyata H, Shimizu K, Kushamae M, Ono I, Nozaki K, Kawashima A, Kawamata T, Aoki T
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Journal Title
Scientific Reports
Volume: 10
Issue: 1
Pages: 8330-8330
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Involvement of neutrophils in machineries underlying the rupture of intracranial aneurysms2020
Author(s)
Kushamae M, Miyata H, Shirai M, Shimizu K, Oka M, Koseki H, Abekura Y, Ono I, Nozaki K, Mizutani T, Aoki T
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Journal Title
Scientific Reports
Volume: 10
Issue: 1
Pages: 20004-20004
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Two Diverse Hemodynamic Forces, a Mechanical Stretch and a High Wall Shear Stress, Determine Intracranial Aneurysm Formation.2019
Author(s)
Koseki H, Miyata H, Shimo S, Ohno N, Mifune K, Shimano K, Yamamoto K, Nozaki K, Kasuya H, Narumiya S, Aoki T.
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Journal Title
Transl Stroke Res.
Volume: Epub ahead of print
Issue: 1
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Computational Fluid Dynamics Simulation of Aneurysm Initiation in Experimental Animal Models2021
Author(s)
Kasai Tomoki, Koseki Hirokazu, Takao Hiroyuki, Fujimura Soichiro, Kato Naoki, Kan Issei, Uchiyama Yuya, Yamanaka Yuma, Ishibashi Toshihiro, Fukudome Kouji, Murayama Yuichi, Yamamoto Makoto
Organizer
The 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC 2021)
Related Report
Int'l Joint Research
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[Book] 完全版 脳血管内治療学2018
Author(s)
滝 和郎、宮地 茂、松丸 祐司、田中 美千裕
Total Pages
512
Publisher
メディカ出版
ISBN
9784840464895
Related Report
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