The elucidation of osteoporosis treatment targeting RNA-binding protein Musashi2 in osteoclast
Project/Area Number |
18K16626
|
Research Category |
Grant-in-Aid for Early-Career Scientists
|
Allocation Type | Multi-year Fund |
Review Section |
Basic Section 56020:Orthopedics-related
|
Research Institution | Kyushu University |
Principal Investigator |
|
Project Period (FY) |
2018-04-01 – 2023-03-31
|
Project Status |
Completed (Fiscal Year 2022)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | Musashi / 破骨細胞 / 骨粗鬆症 / Notchシグナル / 骨代謝 |
Outline of Final Research Achievements |
During osteoclast differentiation, expression of the RNA-binding protein Musashi (Msi) is increased, and cell survival is regulated by Notch signaling, Notch2 and Hes1. Msi has 1 and 2 isoforms, and it is necessary to evaluate the function of both Msi1 and Msi2 in osteoclasts. Msi1 and 2 knockout mice were generated by LysM-Cre mice that selectively knockout (cKO) from monocytic cells with Msi1 and 2 Flox mice. Bone mass in the lumbar spine and femur was analyzed by micro-CT at 2 months age in 5 male and female control (Con) and 5 cKO mice, each. There was no significant difference.
|
Academic Significance and Societal Importance of the Research Achievements |
超高齢社会に伴い、骨粗鬆症患者は急増している。骨粗鬆性骨折は患者の日常生活動作を著しく低下させ、医療費・介護費の上昇で医療経済を圧迫している。そのため、骨吸収を行う破骨細胞を制御する薬剤開発は急務であり、破骨細胞を中心とする骨代謝機構を詳細に解明する必要がある。 本研究ではその一端を担うMusashi遺伝子の役割について解析を行った。
|
Report
(6 results)
Research Products
(33 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Activation of TLR4 Signaling Inhibits Progression of Osteosarcoma by Stimulating CD8-positive Cytotoxic Lymphocytes.2020
Author(s)
Yahiro K, Matsumoto Y, Yamada H, Endo M, Setsu N, Fujiwara T, Nakagawa M, Kimura M, Shimada E, Okada S, Oda Y, Nakashima Y.
-
Journal Title
Cancer Immunol Immunother
Volume: -
Issue: 5
Pages: 745-758
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
[Journal Article] Selective inhibition of mutant IDH1 by DS-1001b ameliorates aberrant histone modifications and impairs tumor activity in chondrosarcoma2019
Author(s)
Nakagawa M, Nakatani F, Matsunaga H, Seki T, Endo M, Ogawara Y, Machida Y, Katsumoto T, Yamagata K, Hattori A, Fujita S, Aikawa Y, Ishikawa T, Soga T, Kawai A, Chuman H, Yokoyama N, Fukushima S, Yahiro K, Kimura A, Shimada E, Hirose T, Fujiwara T, et. al
-
Journal Title
Oncogene
Volume: 38
Issue: 42
Pages: 6835-6849
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-